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Biomedical subjects

D Lambert

Publications and source records attributed to D Lambert.

At least 271 records · Page 15Linked to original sources
PubMedDate not supplied

[Cutaneous manifestations of Yersinia enterocolitica infection].

BACKGROUND: Cutaneous manifestations occurring in infections due to Yersinia enterocolitica are usually erythema nodosum, erythema multiforme or cutaneous vasculitis. The association between Yersinia infection and Sweet's syndrome is rare. We describe such a case contributing to the discussion on this association. CASE-REPORT: A 29-year-old woman had a papulo-pustular eruption with fever associated with arthralgia. The results of the infectious laboratory investigations were negative but Yersinia enterocolitica type 0.9 was isolated from a stool culture. The serologic diagnosis of Yersinia enterocolitica using serum agglutinins was negative. The diagnosis of Sweet's syndrome was made on a skin biopsy specimen. Search for hematology disease or underlying neoplasia was negative. The clinical course was rapidly favorable with antibiotic treatment (ciprofloxacin). DISCUSSION: The diagnosis of Yersinia enterocolitica infection is difficult. Microbiologic diagnosis of Yersinia infection is best achieved by isolation of the bacterium from a clinical specimen of involved tissue. The agglutination test is not highly specific or sensitive. Immunoblotting appears to be more sensitive.

Adult↗
PubMedDate not supplied

[Clinical and histological features of cutaneous drug reactions].

Over the last 20 years, our understanding of cutaneous adverse drug reactions has improved, especially with regard to the management of affected patients. The pathophysiological mechanisms have been studied to improve our understanding. We report different clinical and histological features of cutaneous drug reactions to distinguish a non drug-induced rash from a cutaneous adverse drug reaction.

Drug Eruptions↗
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[Cross-sensitivity between angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonist].

BACKGROUND: Cross-sensitivity between angiotensin-converting enzyme inhibitor-induced angioedema and cough, and angiotensin II receptor antagonist has been reported in the literature. Eczema-like skin reactions have never been documented. We report the first two cases. CASE REPORTS: Two patients, aged 79 and 88 years, with a history of hypertension, were treated with angiotensin-converting enzyme inhibitors, which had been discontinued because of an eczematiform rash. In spite of substitution with an angiotensin II receptor antagonist, the patients had developed the same eruption. The outcome was favourable after discontinuation of the angiotensin II receptor antagonist. The pharmacologic study suggested the possibility of a cross-sensitivity reaction between these two drugs. CONCLUSION: We report the first two cases of a cross-sensitivity between angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonist presenting as an eczematiform rash. The exact mechanism is unknown, but clinicians must be aware that angiotensin II receptor antagonist is not a safe alternative in patients who have a history of eczematiform rash secondary to angiotensin-converting enzyme inhibitors, as has been always reported with angioedema.

Aged↗
PubMedDate not supplied

[Imatinib-induced purpuric vasculitis].

INTRODUCTION: Imatinib (Glivec) is a new molecule that specifically inhibits tyrosine-kinase activity and is used in the treatment of chronic myeloid leukemia. Cutaneous side effects with imatinib are frequent. We report the first case of purpuric vasculitis probably due to this drug. OBSERVATION: A 65 year-old man was treated for chronic myeloid leukemia with imatinib. After two months of treatment, he developed an erythematous and squamatous on the trunk, which regressed spontaneously one week after suspension of the product. Imatinib was reintroduced two months later. The patient immediately developed a painful, infiltrated, purpuric eruption on the legs. Histological examination revealed vasculitis compatible with the diagnosis of toxiderma. Since treatment could not be suspended, oral corticosteroids were introduced and the lesions cleared within three weeks. DISCUSSION: Adverse cutaneous reactions to imatinib are frequent. Their physiopathological mechanism is unknown.

Aged↗
PubMedDate not supplied

[Indications for cryosurgery in dermatology].

Cryosurgery is a controlled refrigeration technique used to destroy some tumoral tissues that are more sensitive to congelation than healthy tissues. The authors present its principle and describe the apparatus: a source of liquid nitrogen, a flexible tube and a probe with a skin-suitable nozzle. The main advantages of the method are its reliability and reproductibility. Among the numerous indications of cryosurgery are all benign tumours of the skin, especially when they are multiple. Concerning malignant lesions, the most usually treated are the multiple forms of basal cell carcinoma, notably the superficial type. Although cryosurgery acts blindly, its indications are increasingly better defined.

Carcinoma↗
PubMedDate not supplied

[Erythema multiforme induced by the combination of phenytoin and cerebral irradiation].

The authors report the case of erythema multiforme characterized by its cephalic onset and its rise after association phenytoin and cranial irradiation, for glioblastoma with epileptic fits. Eight similar cases are observed in literature with the same timing. Benign outcome is not always the rule because 2 patients died. This type of reaction being not forseeing, and outcome very varying, we suggest to avoid phenytoin in patients having a cerebral tumor revealed by epilepsy and needing a cranial irradiation.

Brain↗
PubMedDate not supplied

[Malignant cutaneous hemangioendothelioma. Clinicopathological and ultrastructural aspects (author's transl)].

Malignant cutaneous angio-endothelioma are tumors which develop from vascular endothelium. This is a study of one case along with the data compiled from 118 previously published cases. Clinically, this rare tumor is chiefly seen before the age of twenty of after sixty. Its appearance is polymorphic and often misleading. The clinical course of this disease in adults is always fatal, however, in children 20 p. 100 of the cases are reported curable. The histological picture shows a polymorphic pattern associated with vascular channels anastomosing in a plexiform network with large lacunae surrounded by papillary vegetations and plaques of fusiform, sarcomatoid cells as well as areas of angioblastic secretory cells. The ultrastructural study confirms that the tumor originates from endothelial cells which have lost their capacity to cover the capillary walls.

Aged↗