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Biomedical subjects

D Laky

Publications and source records attributed to D Laky.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Hemangiosarcoma of the thyroid gland. Histological diagnosis problems.

A bleeding tumor of the thyroid gland in a 69-year-old woman is presented. Histologically, it was a hemangiosarcoma with proliferation and vessel neoformation: vascular-like clefts or distinct capillaries with tumoral endo- and perithelial structures were present. With reference to the published data, problems of differential diagnosis in the undifferentiated and giant cell carcinomas of the thyroid gland are discussed.

Aged↗
PubMedDate not supplied

Experimental study on the effects of +Gz. Acceleration under gestational conditions. I. Ultrastructural myocardial lesions.

In the course of a complex experimental study concerning the effects of highly positive acceleration on gestation and development of the neonate, investigations were carried out of ultrastuctural myocardial lesions in the pregnant rat exposed to prolonged gravitational stress (+ 2G). The experimental animals presented various disseminated and partly irreversible myocardial lesions whose pathogeny is discussed.

Animals↗
PubMedDate not supplied

Morphophysiological studies in experimental myocardial aggressions with isoproterenol. Note I. Morphological aspects.

The morphopathogenesis of lesions induced by high doses of isoproterenol injected for 1-7 days and 1-3 months is dynamically studied in groups of Wistar rats and guinea pigs. The disseminated myocardial necroses induced were of a hypoxic nature. By cicatricial substitutions, lesions of cardiosclerosis similar to those observed in pheochromocytoma cases were obtained.

Animals↗
PubMedDate not supplied

Morphophysiological studies in experimental myocardial stress induced by isoproterenol. Note II. The myocardioprotector effect of magnesium ascorbate.

The efficiency of magnesium ascorbate, a new Romanian cardioprotector drug, was studied in guinea pigs and Wistar rats, both normal and with scurvy, within the framework of morphophysiological investigations of the pathogenesis of myocardial disease induced by large doses of beta-adrenergic substances of the isoproterenol type. The preventively treated animals presented only disseminated myocardial ultrastructural lesions within reversible limits. Biochemically, as compared with controls, a return to normal levels of ATP and Mg2+ and a decrease in the uptake of 45CaCl2 by the myocardium were observed. The pharmacological mechanisms of action of magnesium ascorbate are discussed.

Animals↗
PubMedDate not supplied

Myocardial lesions in experimental acute heart failure.

The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the lesional myocardium pictures characterized electron microscopically by a wide range of lesions, from reversible to focal cytolysis, and biochemically by decrease of mitochondrial enzymes, ATP, Mg2-1 X K+ and increase of Na+ X H2O, Ca2+. Problems linked to the pathogenesis, reversibility of the lesions and efficiency of certain therapeutical means are discussed.

Acute Disease↗
PubMedDate not supplied

[Colonic localization of Crohn's disease following a recurrent pseudotumor of the abdominal wall (problems of pathogenesis and therapy)].

A pseudo-tumours of the abdominal wall is described, in the left hypochondrum and the left flank, that, recidivating after 5 years, invaded the splenic angle of the colon. The common histological characteristics were very clear and strongly suggested the presence of Crohn disease. The cellular elements found at the first intervention performed for the extirpation of the tumour in the abdominal wall, as well as at reintervention--consisting in the block resection of the recidivating tumour and of the segment of the colon involved (segmental colectomy)--represented by abundant plasmocytic infiltrates suggest the presence of an immune process. The problem raised is the possibility that the Crohn disease could be incriminated in both instances, since the immunological disturbances can be considered as clearly manifest.

Abdominal Muscles↗
PubMedDate not supplied

Experimental investigations in prolonged myocardial ischaemia. Note I. Biology of the myocardial fiber after transient myocardial fiber after transient myocardial ischaemia.

The first ten days' evolution of post-ischaemic lesions of the premonitory or angina pectoris syndrome type was experimentally studied by the challenge of a short-term (10 and 15 min) ischaemia, of an adaptation to ischaemia and an adaptation followed by prolonged ischaemia (20 and 35 min). Worthy of note was the persistence of reversible lesions after short-term ischaemia and adaptation, and the progressive evolution towards cytolysis and cicatrization of some pancicellular foci after adaptation followed by prolonged ischaemia. The role of mitochondrial lesions, of lysosomal hydrolases, the inefficiency of renewed circulation, as well as problems of diagnosis are discussed.

Angina Pectoris↗
PubMedDate not supplied

Experimental investigations in prolonged myocardial ischaemia. Note II. Biology of the myocardial fiber during permanent ischaemia.

The dynamics of morphologic and biochemical lesions of the myocardial fiber during the first ten days after an experimental myocardial infarction showed an unequal evolution of the lesional picture in the ischaemic area, the intervention of lysosomal hydrolases and the reactions of inflammatory fibrocollagen substitution. Morphologic aspects in the areas neighbouring the infarction and other myocardial areas are discussed.

Animals↗