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Biomedical subjects

D L Wingate

Publications and source records attributed to D L Wingate.

132 records · Page 8Linked to original sources
PubMedDate not supplied

In vivo modulation of small bowel motility by morphine and D-Ala2 D-Leu5 enkephalin.

The effects of morphine and D-Ala2 D-Leu5 enkephalin (DADLE) on intestinal motility were studied in conscious dogs with chronically implanted electrodes. In fed dogs, the normal pattern of irregular spike activity was interrupted by morphine and DADLE; both induced regular spike activity whilst DADLE also induced quiescence. Mr2266 and naloxone abolished the regular spike activity response to morphine and DADLE, but not the quiescence induced by DADLE. Mr2267 had no antagonistic action. Nalorphine methiodide induced a morphine-like response; lower doses had no agonistic action but abolished the response to morphine. The results suggest that regular spike activity induced by morphine and DADLE is a mu receptor effect, whilst the quiescence induced by DADLE may be a delta receptor effect. Morphine appears to have a peripheral site of action.

Animals↗
PubMedDate not supplied

Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon.

Jejunal motility was recorded for 47 h by telemetry from a tethered ingested radio-pill in a patient with irritable colon. In fasted controls, motor complexes are as frequent at night as during the day; the patient with irritable colon had a pronounced reduction in complexes when awake. Two prolonged episodes of pain were associated with irregular contractile activity, and ended when cyclical interdigestive activity resumed. This study suggests that irritable colon may be a disorder affecting the upper digestive tract.

Colon↗