Search PubMed⌕ Search

Biomedical subjects

D L Robbins

Publications and source records attributed to D L Robbins.

58 records · Page 4Linked to original sources

Peripheral hyperostosis in rheumatoid arthritis in the absence of axial involvement.

When diffuse idiopathic skeletal hyperostosis (DISH), or Forestier's disease, coexists with rheumatoid arthritis (RA), the radiographic features of RA are characteristically altered and may be diagnostically misleading. Altered findings include the absence of osteoporosis, bony proliferation around erosions, osteophytosis and ankylosis. Previously reported cases of coexistent RA-DISH have all exhibited characteristic spinal hyperostosis. Two cases are discussed which demonstrate that the distinctive peripheral radiographic findings of RA-DISH may occur in the absence of vertebral involvement.

Arthritis, Rheumatoid↗

Hidden 19S IgM rheumatoid factor in synovial fluid.

Synovial fluid (SF) of 16 adult patients with rheumatoid arthritis (RA) and 9 children with juvenile rheumatoid arthritis (JRA) was investigated for the presence of hidden 19S IgM rheumatoid factor (RF). SF was incubated with 500 IU hyaluronidase/g of SF, dialyzed against acetate buffers at decreasing pH, centrifuged and subjected to chromatography on a Sephadex G-200 column. The resulting IgM-containing fraction of SF from 5 seropositive patients (3 adult RA, 2 JRA patients) demonstrated RF activity by the complement-dependent hemolytic assay. Hidden 19S IgM RF was not found in the IgM-containing fractions of SF from 13 adult seronegative RA patients. Hidden 19S IgM RF was shown in the IgM-containing fraction of SF in 4 of 7 children with seronegative JRA.

Adult↗