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Biomedical subjects

D L Mann

Publications and source records attributed to D L Mann.

At least 271 records · Page 15Linked to original sources
PubMed1973

Crossreactive antigens on human cells infected with Rauscher leukemia virus and on human acute leukemia cells.

A water-soluble component of membranes of cells from a Burkitt's lymphoma cultured cell line was used to develop an antiserum that detects an antigen(s) on acute leukemia cells. This antiserum did not react with nonlymphoid cultured cell lines except for human embryonic kidney cells infected with the Rauscher murine leukemia virus. Absorption studies demonstrated this antigen to be crossreactive with the antigen detected on the human acute leukemia cells.

Animals↗
PubMed1971

Detection of an antigen associated with acute leukemia.

Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.

Animals↗
PubMed1969

Molecular heterogeneity of human lymphoid (HL-A) alloantigens.

Soluble preparations of HL-A alloantigens were separated by gel filtration into components having either the "LA" series or the "4" series of alloantigenic determinants. This separation may indicate that several different structural cistrons within the HL-A (locus) control the expression of these two series of determinants. The alternative possibility, in which one structural cistron with multiple mutational sites controls the synthesis of a single molecule cannot be excluded.

Blood Group Antigens↗