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Biomedical subjects

D L Goldenberg

Publications and source records attributed to D L Goldenberg.

87 records · Page 5Linked to original sources
PubMed1978

Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease.

The synovial membrane histologic sections from patients with six common rheumatic diseases were reviewed without knowledge of the clinical diagnosis. After histopathologic evaluation, the synovial membrane characteristics were grouped according to the patient's clinical diagnosis, and included 29 patients with rheumatoid arthritis, 13 with systemic lupus erythematosus, 17 with degenerative joint disease, 10 with acute bacterial arthritis, 8 with gout, and 13 with pseudogout. The only specific characteristics identified were bacteria (infectious arthritis), crystals (gout, pseudogout), and lymphoid follicles (rheumatoid arthritis). Nevertheless, other characteristic features of differential diagnostic utility were recognized, including the intensity and nature of synovial lining cell hyperplasia and of leukocyte infiltration. Light microscopic histopathologic changes in the common rheumatic diseases are not specific, but are of diagnostic utility. Complete and exhaustive review of each pathologic synovial membrane characteristic provides more justification for the routine use of synovial membrane biopsy as an adjunct to arthrocentesis in the evaluation of common rheumatic diseases.

Arthritis↗
PubMed1977

A musculoskeletal syndrome in intravenous heroin users: association with brown heroin.

During a recent 5-month period, 16 intravenous heroin users were hospitalized with a previously unrecognized complication of drug abuse. The characteristic symptoms were similar in all patients and included fever, paraspinal myalgias, and periarthritis. There was no evidence of bacterial infection, hepatitis, or drug abstinence as the cause of these musculoskeletal symptoms. Continued heroin use was associated with progressive musculoskeletal symptoms, while discontinuation of heroin use resulted in complete recovery. Antibiotics did not affect the outcome, and the syndrome was self-limited in all hospitalized patients. The pathogenesis of this syndrome is unknown but may be related to the heroin, which was described as brown by the patients, or an adulterant.

Adult↗
PubMed1976

Acute infectious arthritis. A review of patients with nongonococcal joint infections (with emphasis on therapy and prognosis).

The clinical course of 59 patients with acute nongonococcal septic arthritis has been reviewed with special emphasis on the changing bacterial spectrum in recent years. The results of treatment were dependent on various factors, including the specific microbial agent and host defenses. Treatment should include parenteral antibiotics and drainage with needle aspiration, except in hips which should be surgically drained. Successful therapy requires rapid initiation of treatment and ongoing assessment of adequacy of response.

Acute Disease↗
PubMed1976

Amyloidosis.

Explore the source record for details and available documents.

Amyloid↗
PubMed1975

Azathioprine hypersensitivity mimicking an acute exacerbation of dermatomyositis.

We describe an unusual hypersensitivity reaction to azathioprine occurring in a patient with dermatomyositis, in which the acute manifestations suggested an exacerbation of the patient's underlying disorder. However, laboratory studies were not consistent with an acute exacerbation of dermatomyositis, and the subsequent clinical course confirmed the impression that the patient's symptoms were due to hypersensitivity to azathioprine. Physicians should be aware that a hypersensitivity reaction to azathioprine may mimic a flare of dermatomyositis.

Acute Disease↗
PubMedDate not supplied

Fibromyalgia syndrome. An emerging but controversial condition.

The clinical manifestations, laboratory findings, and treatment results of 118 patients with fibromyalgia followed up by one investigator were compared with those of other recent reports. The history of this syndrome and recent efforts to establish diagnostic criteria and to understand underlying pathophysiologic mechanisms were studied. A practical, noninvasive office-based evaluation and conservative treatment approach were developed, determined by an understanding of the natural history of this common but controversial disorder.

Fibromyalgia↗
PubMedDate not supplied

Treatment of septic arthritis: comparison of needle aspiration and surgery as initial modes of joint drainage.

Surgery and needle aspiraton have been evaluated as initial modes of drainage in 59 patients with acute septic arthritis. Full recovery was noted in 42% treated surgically at the outset. On the other hand, 67% of those treated by needle aspiration recovered without sequelae, despite the greater prevalence in this group of adverse host factor-eg, serious underlying illness, concommitant extraarticular infection, prior arthritis in the infected joint, and recent antibiotic or immunosuppressive therapy.

Acute Disease↗
PubMedDate not supplied

Inflammatory synovitis in degenerative joint disease.

While the cartilage and bone abnormalities in osteoarthritis (OA) have been adequately described there are few prospective reviews of the histopathologic changes in OA synovia. Therefore 15 consecutive patients with OA who underwent hip or knee arthroplasty were evaluated and random samples of the synovial membranes were studied. Synovial membrane histopathologic abnormalities were present in all but 2; 9 demonstrated mild or moderate synovitis whereas 4 synovial membranes were markedly inflamed. Inflammatory synovitis is often present in OA.

Adult↗