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Biomedical subjects

D L Gardner

Publications and source records attributed to D L Gardner.

150 records · Page 9Linked to original sources
PubMedDate not supplied

New knowledge of the connective tissue diseases I.

This paper examines the extent to which understanding of six of the principle disorders of connective tissue: the glycosaminoglycan storage diseases, ankylosing spondylitis, rheumatoid arthritis, systemic lupus erythematosus, chondrocalcinosis, and osteoarthrosis, has progressed during the past ten years. The paper recalls the pioneer observations of PAUL KLEMPERER on the systemic diseases of collagen, and introduces a series of reviews in which advances in present understanding of some of the connective tissue diseases will be examined in greater detail.

Adult↗
PubMedDate not supplied

Assessing career commitment. The role of staff development.

Staff development and inservice educators may be called on to respond to their organizations' need to recruit and retain nurses. One important role is to promote professional commitment and loyalty. This article describes the Gardner Career Commitment Scale as a tool for use in human resources management and decision making to assess career commitment.

Career Choice↗
PubMedDate not supplied

[Acute muramyl dipeptide-induced arthritis in the baboon Papio cynocephalus].

Daily subcutaneous injections of muramyl dipeptide (MDP) for 14 days into yellow baboons (Papio cynocephalus) caused polyarthritis with a prolific fibrinous exudate, but slight synovial lymphocytosis. In contrast, a single injection of bovine serum albumin (BSA) induced only a low-grade synovitis of the ipsilateral knee. When the schedules were combined the histological features suggested an additive effect between the reactions to BSA and to MDP. Larger amounts of MDP diminished the severity of the synovitis but provoked visceral granulomata.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMedDate not supplied

Synovitis after surgical division of the anterior cruciate ligament of the dog.

The synovial reaction to the surgical division of an anterior cruciate ligament in inbred beagle dogs, was studied. The left ligaments of 16 animals were divided by a 'blind' technique: the right stifle joints were also explored under aseptic conditions but the cruciate ligaments were not cut. Operation was followed by the formation of a blood-stained sterile effusion and by acute synovitis, sustained on the left, transient on the right. The effusion gradually diminished, becoming serous, but haemosiderin remained within subsynoviocytic macrophages for at least 84 days and lymphocytic foci and synovial cell hyperplasia persisted for similar times. It is suggested that interpretation of the cartilage changes in this cruciate ligament division model of osteoarthrosis should take account of the extent and duration of the post-operative inflammation.

Animals↗
PubMedDate not supplied

Impact of confocal scanning optical microscopy on pathological practice.

This review outlines some recent advances likely to influence the hospital laboratory practice of light microscopy, a technique that remains the cornerstone of all surgical pathology. The principal advances are confocal scanning optical ('indirect view') microscopy, to which this short account is restricted, and tandem scanning ('direct view') microscopy.

Histological Techniques↗