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Biomedical subjects

D L Freed

Publications and source records attributed to D L Freed.

At least 19 recordsLinked to original sources
PubMed1985

Lectins.

Explore the source record for details and available documents.

Animals↗
PubMed1979

Persistent warts protected from immune attack by a blocking factor.

Severe warts of 20 years duration, highly resistant to therapy, were found to contain a soluble factor which blocked the local expression of cellular immunity, without affecting systemic immune responsiveness. This finding enabled us to propose therapy by infection, and this had a limited success.

Adult↗
PubMed1978

Mucotractive effect of lectin.

The jackbean lectin concanavalin A caused hypersecretion of mucus in the human nose and the rat jejunum, and histology of the latter demonstrated increased emptying of goblet cells. This "mucotractive" effect has implications for the fibre hypothesis and might be therapeutically useful in patients with cystic fibrosis.

Animals↗
PubMed1977

Antibiody-facilitated digestion and its implications for infant nutrition.

A model of digestion is proposed in which oligopeptides arriving at the small bowel epithelium are bound to secretory antibodies, which hold them in contact with proteases and thus facilitate their breakdown and utilization. "Immunity" and "digestion" are thus seen as two sides of the same coin. Absence of this pathway, predictably, would cause a degree of malabsorption, while partial deficiency (either quantitative or qualitative) would give rise to a coeliac-like illness. Breast-feeding with colostrum and then milk provides the infant gut with both immunity and "digestivity", and this could be adopted therapeutically for coeliac disease and other consequences of local immunodeficiency.

Antigen-Antibody Reactions↗
PubMed1977

Respiratory allergy and month of birth.

A total of 476 patients with respiratory allergy were interviewed to establish whether the season of birth influenced the type of allergy experienced. Patients with perennial symptoms did not differ from the general population of the U.K. in the distribution of their months of birth. Patients with summer seasonal symptoms attributable to grass pollen sensitivity were more likely to have been born in December to February than in August to November. This trend was most significant in female patients who did not have associated perennial symptoms and who developed symptoms early in life. Other significant differences were also noted between groups of patients complaining of the same symptoms. More males than females had summer seasonal symptoms whereas more females than males had perennial symptoms. Patients who had both perennial symptoms and summer seasonal exacerbations had a higher incidence of a positive family history of atopy and developed symptoms earlier in life than those patients who had summer seasonal or perennial symptoms only.

Adolescent↗
PubMed1976

Local nasal desensitization provoking systemic illness with proteinuria.

We report a case of allergic rhinitis with systemic illness and proteinuria, which was repeatedly provoked by nasal exposure to allergen. Local nasal desensitization resulted in remission of both rhinitis and systemic illness. The disease was associated with systemic complement fixation via the classical pathway.

Adolescent↗