Search PubMed⌕ Search

Biomedical subjects

D L Coppel

Publications and source records attributed to D L Coppel.

34 records · Page 2Linked to original sources
PubMed1975

The effect of non-depolarizing relaxants on plasma potassium.

Plasma potassium concentrations were measured in four groups of unpremedicated patients in whom anesthesia was induced with thiopentone 5 mg/kg followed by tubocurarine 0.5 mg/kg, gallamine 2 mg/kg, pancuronium 0.1 mg/kg or AH 8165 1.25 mg/kg, prior to elective dental surgery. There was a small but consistent decrease in plasma potassium following the injection of pancuronium and, to a lesser extent, following gallamine. No changes were found during the first 10 min following tubocurrarine. With AH 8165 there was an early reduction in plasma potassium but the values returned to within normal limits by 5 min.

Adult↗
PubMed1973

Evaluation of hyperventilation in treatment of head injuries.

Reduction of the partial pressure of carbon dioxide in the arterial blood by mechanical hyperventilation (Pco(2) 25-30 mm Hg; Po(2) 100-150 mm Hg) may be beneficial in cases of severe head injury. To evaluate its efficacy and establish prognostic guidelines intracranial pressure, radiocirculograms, and cerebrospinal fluid (C.S.F.) lactate levels were studied in 31 patients. In survivors intracranial pressure fell and cerebral blood flow improved with treatment. A C.S.F. lactate greater than 55 mg/100 ml was associated with a poor prognosis. Selection of patients was based on clinical judgement, and adults with signs of extensive brain damage were excluded. The importance of an adequate airway and resuscitation is stressed before a final decision is made. The object of treatment is to improve the quality of survival and the criteria measured may aid in the distinction between patients with a potential for good recovery and those capable only of a vegetative existence. Many associated factors as well as hypocapnia reduce intracranial pressure, and these are discussed. We believe that hyperventilation may improve some head injuries, and further study is indicated.

Adolescent↗