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Biomedical subjects

D L Coleman

Publications and source records attributed to D L Coleman.

At least 181 records · Page 10Linked to original sources
PubMed1971

Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase.

The rate of synthesis of delta-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of delta-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for delta-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.

Alleles↗
PubMed1966

Diabetes, a new mutation in the mouse.

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.

Animals↗