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D L Anderson

Publications and source records attributed to D L Anderson.

At least 19 recordsLinked to original sources

A model to explain the various paradoxes associated with mantle noble gas geochemistry.

As a result of an energetic accretion, the Earth is a volatile-poor and strongly differentiated planet. The volatile elements can be accounted for by a late veneer ( approximately 1% of total mass of the Earth). The incompatible elements are strongly concentrated into the exosphere (atmosphere, oceans, sediments, and crust) and upper mantle. Recent geochemical models invoke a large primordial undegassed reservoir with chondritic abundances of uranium and helium, which is clearly at odds with mass and energy balance calculations. The basic assumption behind these models is that excess "primordial" 3He is responsible for 3He/4He ratios higher than the average for midocean ridge basalts. The evidence however favors depletion of 3He and excessive depletion of 4He and, therefore, favors a refractory, residual (low U, Th) source Petrological processes such as melt-crystal and melt-gas separation fractionate helium from U and Th and, with time, generate inhomogeneities in the 3He/4He ratio. A self-consistent model for noble gases involves a gas-poor planet with trapping of CO2 and noble gases in the shallow mantle. Such trapped gases are released by later tectonic and magmatic processes. Most of the mantle was depleted and degassed during the accretion process. High 3He/4He gases are viewed as products of ancient gas exsolution stored in low U environments, rather than products of primordial reservoirs.

Journal Article

The helium paradoxes.

The ratio 3He/4He (R) plays a central role in models of mantle evolution that propose an undegassed lower mantle, rich in the primordial isotope 3He. A large primordial volatile-rich reservoir, a feature of recent models, is inconsistent with high-temperature accretion and with estimates of crustal and bulk Earth chemistry. High R can alternatively reflect high integrated 3He/(U+Th) ratios or low 4He abundances, as expected in refractory portions of the upper mantle. I show that high R materials are gas-poor and are deficient in radiogenic 4He compared with midocean ridge basalts. The seemingly primitive (i.e., high R) signatures in "hotspot" magmas may be secondary, derived from CO2-rich gases, or residual peridotite, a result of differential partitioning of U and He into magmas. A shallow and low 3He source explains the spatial variability and the temporal trends of R in ocean islands and is consistent with a volatile-poor planet. A shallow origin for the "primitive" He signature in ocean island basalts, such as at Loihi, reconciles the paradoxical juxtaposition of crustal, seawater, and atmospheric signatures with inferred "primitive" characteristics. High 238U/204Pb components in ocean island basalts are generally attributed to recycled altered oceanic crust. The low 238U/3He component may be in the associated depleted refractory mantle. High 3He/4He ratios are due to low 4He, not excess 3He, and do not imply or require a deep or primordial or undegassed reservoir. 40Ar in the atmosphere also argues against such models.

Journal Article

Results from the Mars Global Surveyor Thermal Emission Spectrometer.

The Thermal Emission Spectrometer spectra of low albedo surface materials suggests that a four to one mixture of pyroxene to plagioclase, together with about a 35 percent dust component provides the best fit to the spectrum. Qualitative upper limits can be placed on the concentration of carbonates (<10 percent), olivine (<10 percent), clay minerals (<20 percent), and quartz (<5 percent) in the limited regions observed. Limb observations in the northern hemisphere reveal low-lying dust hazes and detached water-ice clouds at altitudes up to 55 kilometers. At an aerocentric longitude of 224 degrees a major dust storm developed in the Noachis Terra region. The south polar cap retreat was similar to that observed by Viking.

Atmosphere

Prospective multicenter study of sulfonylurea ingestion in children.

OBJECTIVE: Sixty-eight percent of pediatric sulfonylurea ingestions reported to poison centers do not result in laboratory or behavioral effects. Consequently, if all exposed children are admitted overnight or for 24 hours for these exposures, it will result in 600 to 700 hospital admissions per year of children who will remain free of symptoms. We prospectively studied exposures reported to 10 regional poison centers to determine if it were possible to differentiate those patients who would have symptoms from those who would remain symptom free. METHODS: We analyzed all sulfonylurea exposures in children < or = 12 years old reported to the participating poison centers. Hypoglycemia was defined as blood glucose (BG) concentration < 60 mg/dl. RESULTS: Hypoglycemia developed in 56 (30%) of 185 exposed patients. Fifty-four of the 56 (96%) hypoglycemic patients had development of hypoglycemia within 8 hours of ingestion. Eighty-seven of the patients were initially managed with oral supplementation only; in 13 cases, treatment advanced to intravenous administration of glucose or glucagon with the onset of hypoglycemia. There was no statistical difference in medical outcome between patients monitored during oral supplementation versus during intravenous infusion of dextrose. Ingestions analyzed by time of day did not predict risk of hypoglycemia. Sufficient data were available for 103 (58%) of the 177 patients who ingested glyburide or glipizide to calculate a toxic dose/weight ratio. Of these 103 patients, 31 of 36 patients who ingested < or = 0.3 mg/kg remained symptom free, whereas 31 of 67 who ingested more than 0.3 mg/kg had BG concentrations < 60 mg/dl (p < 0.005, 95% confidence interval 0.05 to 0.58; sensitivity 86%, specificity 46%). CONCLUSION: A lack of onset of hypoglycemia (BG > 60 mg/dl) in the first 8 hours after ingestion is predictive of a benign outcome in accidental pediatric sulfonylurea ingestion. Clinical observation of children for onset of hypoglycemia during oral feeding alone appears safe. Some children with symptoms of hypoglycemia need to receive intravenous dextrose therapy. Time of day of ingestion is not predictive of risk of hypoglycemia. Finally, at this time it appears inappropriate to use a milligram per kilogram body weight dose as a guide for management decisions.

Accidents

Influence of the pH of cardioplegic solutions on cellular energy metabolism and hydrogen ion flux during neonatal hypothermic circulatory arrest and reperfusion: a dynamic 31P nuclear magnetic resonance study in a pig model.

OBJECTIVES: The pH of cardioplegic solutions is postulated to affect myocardial protection during neonatal hypothermic circulatory arrest. Neither optimization of cardioplegic pH nor its influence on intracellular pH during hypothermic circulatory arrest has been previously studied in vivo. Thus we examined the effects of the pH of cardioplegic solutions on postischemic cardiac function in vivo, including two possible operative mechanisms: (1) reduction in adenosine triphosphate use and depletion of high-energy phosphate stores or (2) reduction of H+ flux during reperfusion, or both. METHODS: Dynamic 31P spectroscopy was used to measure rates of adenosine triphosphate use, high-energy phosphate depletion, cytosolic acidification during hypothermic circulatory arrest, and phosphocreatine repletion and realkalinization during reperfusion. Neonatal pigs in three groups (n = 8 each)--group A, acidic cardioplegia (pH = 6.8); group B, basic cardioplegia (pH = 7.8); and group N, no cardioplegia--underwent hypothermia at 20 degrees C with 60 minutes of hypothermic cardioplegia followed by reperfusion. RESULTS: Recoveries of peak elastance, stroke work, and diastolic stiffness were superior in group B. Indices of ischemic adenosine triphosphate use, initial phosphocreatine depletion rate, and tau, the exponential decay half-time, were not different among groups. Peak [H+] in group A (end-ischemia) was significantly elevated over that of group B. The realkalinization rate was reduced in group B compared with that in groups A (p = 0.015) and N (p = 0.035), with no difference between groups A and N (p = 0.3). Cytosolic realkalinization rate was markedly reduced and the half-time of [H+] decay was increased during reperfusion in group B. CONCLUSIONS: Superior postischemic cardiac function in group B is not related to alterations in ischemic adenosine triphosphate use or high-energy store depletion, but may be due to slowing in H+ efflux during reperfusion, which should reduce Ca++ and Na+ influx.

Adenosine Triphosphate

Prospective multicenter evaluation of tramadol exposure.

BACKGROUND: Tramadol is a novel analgesic possessing both opiate and noradrenergic effects. Its low potential for abuse suggests increasing use, but there are limited data on the toxicity in overdose. METHODS: Multicenter prospective case series. All exposures from October 1995 through August 1996 reported to seven Poison Centers were evaluated. RESULTS: There were 126 cases of which 87 were tramadol alone. Of the tramadol alone cases, 51 were female (59%). Age ranged from 1 to 86 y with a mean and median of 26.8 y (SD 17.2) and 25 y, respectively. There were 15 cases of children less than 6 years old. Symptoms reported with overdose were: lethargy 26 (30%), nausea 12 (14%), tachycardia 11 (13%), agitation 9 (10%), seizures 7 (8%), 4 each (5%) of coma and hypertension, and respiratory depression 2 (2%). All seizures were brief. Naloxone reversed sedation and apnea in 4 of 8 patients. One patient experienced a seizure immediately after administration of naloxone. Other treatments were: diazepam (3 patients), and phenytoin, lorazepam and nifedipine (1 patient each). Tramadol 500 mg was the lowest dose associated with seizure, tachycardia, hypertension or agitation while 800 mg was the lowest dose associated with coma and respiratory depression. Urine drug screens performed on 19 patients were negative for opiates. All symptomatic cases exhibited effects within 4 h of ingestion. Mean hospital stay was 15.2 h (range 2-96 h, SD 15.8). Nineteen patients were admitted to an intensive care unit with a mean stay of 25 h (SD 20). DISCUSSION: Much of the toxicity in tramadol overdose appears to be attributable to the monoamine uptake inhibition rather than its opioid effects. Agitation, tachycardia, confusion and hypertension suggest a possible mild serotonin syndrome. No arrhythmias beyond tachycardia were seen. CONCLUSION: This study suggests significant neurologic toxicity from tramadol overdose. Serious cardiovascular toxicity was not seen.

Adolescent

Nurses: act now!

Drawing from the tradition of the theater, we can create a new paradigm for creating humor, health and happiness. The basis of this paradigm: we become what we do. In other words, we can become healthier and more successful by consciously modeling (acting) the happy, healthy traits we desire. In addition, staging, scripting, costuming and acting the part can stimulate our bodies to produce neuropeptides such as endorphins and other chemicals that bolster the immune system and promote well being.

Adaptation, Psychological

The role of external nonrigid ankle bracing in limiting ankle inversion.

The purpose of this study was to measure the effectiveness of the nonrigid subtalar stabilizer (STS) ankle brace under conditions similar to an unexpected fall that could lead to a lateral ligament injury. The calcaneal inversion angles, times, and ground reaction forces were measured when the subject's right foot, bearing body weight, was suddenly inverted to a side slope of 22 degrees. Thirty subjects, 15 women and 15 men, participated in the study. The overall inversion drop was divided into two phases, free fall and loading. Based on the data of this study it is suggested that the major function of a brace is to restrict the amount of foot inversion during the fall before actual landing occurs rather than functioning as a force bypass for the lateral ligaments during loading after foot contact. The results showed that the brace significantly (p < 0.05) reduced the maximum calcaneal inversion angle from 27.4 +/- 6.1 to 18.3 +/- 6.0 degrees for the overall drop, significantly lengthened the inversion time from 0.14 +/- 0.04 to 0.18 +/- 0.04 s for the overall drop, and significantly reduced the calcaneal peak inversion velocity from 324.6 +/- 111.9 to 165.2 +/- 66.5 degrees/s during loading, and from 278.7 +/- 120.0 to 183.0 +/- 108.7 degrees/s for the overall drop. Following exercise, which incorporated lateral movements and sprinting, the STS ankle brace continued to provide significant (p < 0.05) reduction in the calcaneal inversion angle and velocity, although some of its effectiveness was reduced.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidental Falls

A pig model for advanced laparoscopic biliary procedures.

Advanced laparoscopic biliary procedures can be undertaken in a pig model, but the small size of the normal common bile duct makes learning difficult. We have developed a prepared pig model of common bile duct ligation on which to practice advanced laparoscopic biliary surgery. The pig's distal common bile duct was occluded using several different methods via a minilaparotomy. Laparoscopic biliary procedures were undertaken 6-21 days later. The common bile duct became dilated to between 2 and 3 cm in diameter in all cases, and this was well tolerated by the animals. All advanced laparoscopic biliary procedures were possible, including choledochoscopy, exploration of the bile duct, and cholecystojejunostomy. Short-term common bile duct ligation is well tolerated in pigs and can be used to create a model for practicing advanced laparoscopic biliary procedures.

Animals

A comparison of tympanic thermometer readings to pulmonary artery catheter core temperature recordings.

The purpose of this study was to determine the accuracy of FirstTemp (Intelligent Medical Systems, Carlsbad, CA) tympanic thermometer readings compared with core body temperatures obtained via pulmonary artery catheter (PAC). Five measurements were obtained on 19 cardiovascular surgery patients. Tympanic thermometer measurements tended to be higher than PAC measurements. However, most of the differences were not clinically significant. Differences found between right and left ear measurements were most likely due to poor measurement technique. When the correct technique is used, nurses can be confident that tympanic temperature readings are clinically accurate.

Aged

Bacillus subtilis mutants defective in bacteriophage phi 29 head assembly.

Virus assembly mutants of asporogenous Bacillus subtilis defective in bacteriophage phi 29 head assembly were detected by the use of antibodies that reacted strongly with the free dodecameric phi 29 portal vertex composed of gene product 10 (gp10) but weakly with the portal vertex assembled into proheads or phage. Phage adsorption and the synthesis of phage proteins, DNA-gene product 3, and prohead RNA were normal in these mutants, but prohead and phage production was greatly reduced. The assembly defect was transferred to competent B. subtilis by transformation and transduction. PBS1 transduction showed that the vam locus was linked to Tn917 located at 317 degrees on the B. subtilis chromosome.

Bacillus Phages

Laparoscopic gastrointestinal anastomoses.

In a preliminary study of laparoscopic gastrointestinal anastomosis, a gastric outlet obstruction was created under laparoscopic control in six domestic pigs, weighing an average of 25 kg. A simultaneous gastroenterostomy was formed with an end-stapling device. All animals recovered clinically, and good anastomotic healing was documented 1 week postoperatively. The authors suggest that an end-stapling device could be one method of creating a gastrointestinal anastomosis for humans that is safe and reliable, allows rapid recovery and decreases hospital stay.

Anastomosis, Surgical

Use of spherical targets to minimize effects of neutron scattering by hydrogen in neutron capture prompt gamma-ray activation analysis.

For hydrogenous targets that are thinner than they are wide, element sensitivities (counts.s-1.mg-1) for determining concentrations of elements by neutron capture prompt gamma-ray activation analysis (PGAA) are enhanced relative to sensitivities obtained from measurements on nonhydrogenous materials. These enhancements are caused mainly by elastic neutron scattering by H, which changes the average neutron fluence rate within the matrix. The magnitude of the effect depends on the macroscopic scattering and absorption cross sections and on the size, shape, and orientation of the target with respect to the neutron beam. Sensitivities increase linearly with H density for thin targets of constant size and shape and also vary with target shape. Theoretical work was shown that element sensitivities for hydrogenous targets in the form of spheres are least affected by neutron scattering. Methods were devised for creating solid spheres and for containing liquids in spherical shapes. Element sensitivities were determined for spheres and disks of several hydrogenous materials. For H, B, Cl, K, Br, and Cd, sensitivities for spheres were found to be less affected by neutron scattering. Exceptions were Sm and Gd sensitivities measured in liquids contained in quartz globes.

Chemistry Techniques, Analytical

Thyroid stimulating hormone and prolactin responses to thyrotropin releasing hormone in nondepressed alcoholic inpatients.

Thyroid stimulating hormone (TSH) and prolactin (PRL) responses to thyrotropin releasing hormone (TRH) stimulation are sometimes blunted in alcoholic subjects; however, the mechanisms involved in these phenomena have not been established. We hypothesized that elevations in free thyroid concentrations might be related to these abnormal responses and then tested that hypothesis in a sample of nondepressed alcoholic inpatients (n = 21). Four alcoholic patients had delta max TSH responses that were < 7 mIU/l; three had PRL responses at or below 8 micrograms/l. Baseline TSH was the only significant predictor of peak TSH; however, free thyroxine (FT4) and baseline TSH both were significant predictors of peak PRL. The average baseline FT4 concentration in alcoholic patients was significantly higher than that in healthy control subjects (n = 10). Our data, thus, suggest that small elevations of FT4 play a role in the inhibition of TSH and PRL responses to TRH among nondepressed, abstinent alcoholic patients.

Adult

Effects of target shape and neutron scattering on element sensitivities for neutron-capture prompt gamma-ray activation analysis.

Results are presented for a study of the effects of neutron scattering by hydrogen on element sensitivities for in-beam neutron capture prompt gamma-ray activation analysis. In a scattering matrix, sensitivities vary as a function of both the scattering density, i.e., the number of scatters per unit volume and the magnitude of scattering cross sections, and the target geometry, i.e., the target shape and orientation with respect to the neutron beam. Element sensitivities (counts.s-1.mg-1) increased linearly with H density (g.mL-1) for H, B, Na, Cl, K, Mn, Br, Ag, Cd, I, Sm, and Gd, measured for liquids packaged in Teflon bags. Nine of the 12 elements studied had 1.69 +/- 0.18% sensitivity enhancement per percent increase in H density. Samarium sensitivity was enhanced by only 0.54 +/- 0.07%/% H, which may indicate that neutron scattering by H causes a shift in the energy distribution of the neutrons. Manganese sensitivity was enhanced by 2.44 +/- 0.26%/% H. The enhancement of the sensitivity for H itself varied with matrix composition. For several series of disk-shaped, solid, hydrogenous targets, element sensitivities increased with decreasing target thickness until, at some limiting thickness, this trend was reversed. Consistent with theory, sensitivities measured for spherical hydrogenous targets showed no enhancement.

Chlorine

Phylogenetic analysis and secondary structure of the Bacillus subtilis bacteriophage RNA required for DNA packaging.

An unusual RNA molecule encoded by the Bacillus subtilis bacteriophage phi 29 is a structural component of the viral prohead and is required for the ATP-dependent packaging of DNA. Here we report a model of secondary structure for this prohead RNA developed from a phylogenetic analysis of the primary sequences of prohead RNAs of related phages. Twenty-nine phages related to phi 29 were found to produce prohead RNAs. These RNAs were analyzed by their ability to replace phi 29 RNA in in vitro phage assembly, by Northern blot hybridization with a probe complementary to phi 29 RNA, and by partial and complete sequence analyses. These analyses revealed four quite different sequences ranging in length from 161 to 174 residues. The secondary structure deduced from these sequences, in agreement with earlier observations, indicated that prohead RNA is organized into two domains. The larger 5'-domain (Domain I) is composed of 113-117 residues and contains four helices. Three of these helices appear to be organized into a central stem that is interrupted by two unpaired loops and the fourth helix and loop. The smaller 3'-domain (Domain II) is composed of 40-44 residues and consists of two helices. Domains I and II are separated by 8-13 unpaired residues. Nuclease cleavage occurs readily in this single-stranded joining region, and this cleavage allows the subsequent separation of the two RNA domains. The separated Domain I is fully active in DNA packaging in vitro. The functional significance and biological role of Domain II are unknown. The phylogenetic secondary structure model provides a basis for further analysis of the role of this RNA in bacteriophage morphogenesis.

Bacillus subtilis

Giant fibrovascular polyps of the esophagus.

A 77-yr-old man with chest discomfort and progressive dysphagia was found to have an intraluminal esophageal lesion of remarkable size. A giant fibrovascular polyp (11 x 7 x 3.5 cm) was successfully removed surgically by a transcervical approach. This unusual benign esophageal lesion is discussed in terms of classification and clinical presentation from a historical perspective. Particular attention is focused on the current approach to diagnosis and management. Endoscopic ultrasonography was employed as part of the evaluation.

Aged

Cholera toxin inhibits resting human T cell activation via a cAMP-independent pathway.

The catalytic subunit of cholera toxin (CT) can chemically modify the alpha polypeptides of certain G-binding proteins and thus alter their function. In order to study the involvement of CT-sensitive G proteins in T cell activation, we have utilized CT in an in vitro system in which purified, resting human peripheral T cells are activated by anti-CD3 antibodies and rIL-2. Perturbation of the TCR/CD3 molecular complex by anti-CD3 antibodies causes changes in membrane phospholipids and induces a rise in cytoplasmic Ca2+. These events, however, are insufficient to allow progression into cellular proliferation and addition of IL-2 is required. Under these conditions, treatment of cells with a low concentration of CT (2 ng/ml) causes a significant inhibition of the anti-CD3-induced calcium event as well as the anti-CD3 plus IL-2-stimulated proliferation. Under our experimental conditions, inhibition of both proliferation and intracellular Ca2+ elevation by CT requires the involvement of the TCR/CD3 complex. This is supported by the observation that the toxin does not inhibit either the proliferation triggered by ionomycin and PMA or the Ca2+ influx induced by the ionophore. These data suggest that in TCR/CD3-mediated T cell activation CT acts at a point between TCR/CD3 perturbation and the generation of intracellular Ca2+. In view of the ability of CT to activate the alpha subunit of the G protein that stimulates adenyl cyclase (G alpha s), it is possible that the effect of CT on T cells is secondary to intracellular elevation of cAMP. However, measurement of cAMP levels both early after CT addition and at later time points, when proliferation is maximal, reveals lack of cyclic nucleotide accumulation. The presented data are consistent with the interpretation that the CT-mediated inhibition is caused by the modification of a G-binding protein that is either directly or indirectly associated with triggering of T cells via the TCR/CD3 molecular complex. The data also suggest that this protein is not G alpha s and it probably represents an as yet unidentified moiety or one of the several G proteins that have been recently described as regulators of phospholipase C activation.

Antibodies, Monoclonal