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Biomedical subjects

D Kumar

Publications and source records attributed to D Kumar.

At least 415 records · Page 23Linked to original sources
PubMed1981

Correlation between the serum norethindrone (NET) levels attained after insertion of a silastic implant releasing norethindrone acetate and the endogenous hormones particularly progesterone.

Six normally menstruating women were inserted each with a single silastic implant-D releasing norethindrone acetate (NETA). The levels of endogenous hormones, FSH, LH, E2 and progesterone, were estimated by radioimmunoassay (RIA) procedures in the control and treatment cycles. In addition, the levels of drug in the serum as norethindrone (NET) which is a major metabolite of NETA were also estimated by RIA procedures in the treatment cycles. In all, 12 treatment cycles were studied. In the initial treatment cycles (1st/2nd or 3rd), the serum NET levels were either 1 ng/ml or above. The LH and FSH showed either normal or suppressed mid-cycle peaks, but the progesterone levels were completely suppressed. In the sixth treatment cycles, the serum NET levels were either 0.5 ng/ml or below. The FSH and LH mid-cycle peaks were lower but distinct while the luteal progesterone levels were of normal ovulatory type. These studies lead us to the conclusion that a serum level of NET of the order of 1 ng/ml is required to bring about suppression of luteal progesterone, either as a result of direct action on the ovary or through suppression of pituitary gonadotropins. When the serum level falls to 0.5 ng/ml or below, the suppressive effect is removed and ovulatory pattern of progesterone returns.

Drug Implants↗
PubMed1981

Case report. Circumaortic left renal vein.

Although computed tomographic (CT) characteristics of the inferior vena cava may mimic lymphadenopathy, careful appraisal of the vascular anatomy can diagnose major vascular anomalies by noninvasive techniques, eliminating the need for angiography as well as alerting our surgical colleagues of the benign nature of this entity. We document the first case of circumaortic renal vein by CT, discuss the CT appearance, and review its clinical significance.

Adult↗
PubMed1980

HLA-DRw antigens in Mexican-American and Black-American diabetic patients.

HLA-A, - B, and -C antigens were studied in 67 Mexican-American and 38 black-American diabetic patients who had the onset of their disease before age 31 yr. Control populations consisted of 322 Mexican-American and 367 black-American subjects for HLA-A, -B, and -C antigens. In addition, HLA-DRw antigens were studied in 60 Mexican-American and 34 black-American diabetic patients. Control populations for HLA-DRw antigens consisted of 189 Mexican-American and 145 black-American subjects. We found that juvenile-onset--diabetic patients of Mexican-American origin who had the onset of their disease before age 19 demonstrated a significant increase in HLA-DRw4. HLA-DRw4 was also significantly increased in black-American patients with juvenile-onset diabetes mellitus. HLA-DRw2 was not detected in any patient with juvenile-onset diabetes in either ethnic group. A significant association was found between HLA-B18 and HLA-DRw3 in Mexican-American juvenile-diabetic patients. These findings, which are comparable to those in similar Caucasian patients, provide additional information to support the hypothesis that HLA-DRw antigens play a major role in determining the susceptibility to juvenile-onset diabetes mellitus.

Adult↗
PubMed1980

Histological study on the retrocerebral-endocrine complex with special reference to neurohaemal involvement of aorta and pericardial cells in Coccinella septempunctata (L.) (Coccinellidae-Coleoptera).

About nine median neurosecretory cells (NSC) are situated in the antero-dorsal position on either side of the pars intercerebralis of the brain. No lateral NSC could be detected. The axonic bundles, after their decussation, emerge out of the brain in the form of a single nervi corporis cardiaci (NCC) on either side. These soon undergo a dichotomy--one set of nerve fibers enter the lobulated corpus cardiacum (CC) and the other set ramify over the surface of the aorta and sends out distinct branches to the individual large, oval-shaped, pericardial cells all along the length of the aorta. Presence of neurosecretory material (NSM) could be demonstrated both in aortal wall as well as along the nerve branches that innervate the pericardial cells. Traces of NSM could be detected within the cytoplasm of the pericardial cells. While the involvement of aorta and pericardial cells, as an additional neurohaemal organs was well documented for several species of Hemiptera, the present report for Coleoptera seems to be new and of considerable interest. Thus it would seem that the role of the aorta and pericardial cells as accessory neurohaemal organ is perhaps of wider occurrence than was hitherto believed. The irregularly lobulated CC contains copious amounts of thick clumps of NSM which, by and large, tends to show a peripheral distribution. Few intrinsic secretory cells are noticeable. The CC, at its postero-lateral border forms a cap- or hood-like projection that partially overlaps the corpus allatum (CA) below. At the mesial border, the CC sends out a lobe which seems to fuse with the aortal wall. The shape of CA shows individual variation. In some, it is oval while in others it is spherical, but always with a well defined outline. No allatal nerve is demonstrable. Instead, the CA is broadly connected with the hood region of the CC. AF-positive material is also detectable in the CA, which also tends to be peripherilly distributed.

Animals↗
PubMed1980

Histological studies on the neuroendocrine organs and retrocerebal complex of Crynodes peregrinus Fuessly (Chrysomelidae-Coleopt.).

The neuroendocrine system of Crynodes peregrinus has been described by using Alkehyde-Fuchsin technique (AF) on whole amounts and sections. Four groups of neurosecretory cells are present in the brain--including the two median groups with 18-20 cells each and two lateral groups with four cells each. The neurosecretory material (NSM) reaches the corpora cardiaca (CC) by nervi corporis cardiaci I. The CC is divisible into two distinct parts--central nervous part surrounded by the cellular cortical zone. The NSM of cerebral origin is stored and released from the CC. Intrinsic cells are found to be absent in the CC. AF positive material is found also in the corpora allata.

Animals↗
PubMed1979

Angiomatous lymphoid hamartoma or pseudolymphoma of pelvic retroperitoneum: clinical significance and evaluation of pelvic ureter.

Angiomatous lymphoid hamartomas or pseudolymphomas have been reported most commonly within the chest and usually are mistaken for thymic tumors of lymphomatous tissue. Pelvic retroperitoneal location, to our knowledge, has been described only on three occasions. Only a high index of suspicion can make one recognize this rare lesion and save unnecessary radical surgery and/or radiation therapy. Removal of the mass led to dissappearance of associated systemic manifestations in many of the patients.

Adult↗
PubMed1979

Insulin allergy: reaginic antibodies to insulin and proinsulin.

To investigate the involvement of proinsulin (one of the contaminant proteins of therapeutic insulin) in systemic insulin allergy, we studied seven diabetic patients who presented with generalized insulin allergy. Commercial and highly purified (single component) insulins produced almost identical responses on the intradermal tests. In all cases, [125I]bovine insulin and [125I]bovine proinsulin bound to the circulating reaginic immunoglobulins. The binding of [125A]proinsulin was blocked completely by unlabeled insulin and was uneffected by bovine C-peptide, indicating a cross-reaction of proinsulin with antinsulin reaginic immunoglobulins and the absence of proinsulin-specific reaginic antibodies. These observations suggest insulin, but not proinsulin, as the mediator of the immediate insulin allergic reaction.

Adult↗