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Biomedical subjects

D Kohn

Publications and source records attributed to D Kohn.

At least 109 records · Page 6Linked to original sources
PubMed1981

Thrombotic thrombocytopenic purpura with a subacute course: remission after steroids and high-dose plasma exchange.

A case of thrombotic thrombocytopenic purpura with an unusual subacute course is described. Treatment was initiated after the patient had been ill for four weeks. Low-dose plasma exchange (10 ml/kg body weight per day) was associated with a sharp drop in the reticulocyte count and a transient reduction of lactate dehydrogenase activity to within the normal range. The administration of corticosteroids was followed immediately by the disappearance of neurological symptoms, and after high-dose plasma exchange (25 ml/kg body weight per day) all the symptoms of disease remitted. The remission has lasted for 10 months; we suggest that each of the therapeutic measures employed played a role.

Adrenal Cortex Hormones↗
PubMed1981

Iron loading and endocrine functions in nontransfused patients with beta-thalassemia intermedia or sickle-cell thalassemia.

Body iron stores and endocrine functions were determined in eight patients with chronic hemolytic anemia who had received only small amounts of blood and no iron preparations. Four patients had beta-thalassemia intermedia (BTI) and four had sickle-cell thalassemia (SCT). Hemoglobin levels and degrees of hemolysis were similar in both groups of patients. The patients with BTI showed clear evidence of iron overload, whereas there was no evidence of iron accumulation in the patients with SCT. The three patients with BTI who had endocrinologic evaluations showed endocrine dysfunctions. Two patients with SCT had no endocrine abnormalities and the other two probably had some degree of primary hypogonadism. Iron overload in patients with thalassemia probably results from excessive intestinal iron absorption and can damage various parenchymal and endocrine organs, even in the absence of an external source of iron.

Adult↗
PubMed1977

Semiquantitative cytochemical estimation of beta-glucuronidase activity in peripheral lymphocytes in healthy human subjects.

A semiquantitative cytochemical evaluation of beta-glucuronidase activity in peripheral lymphocytes in 123 normal sybjects was made. It was found that the enzymatic activity was influenced by age but not by sex. Activity was weak in newborn infants but increased with age and reached maximal values in old subjects. Age should therefore be taken into consideration when the enzyme activity is evaluated.

Adolescent↗
PubMedDate not supplied

Preoperative ultrasonographic mapping of calcium deposits facilitates localization during arthroscopic surgery for calcifying tendinitis of the rotator cuff.

Calcifying tendinitis is a relatively common disorder of the rotator cuff. For symptomatic patients, excision of the calcium deposits offers reliable pain relief. The arthroscopic technique is demanding. Arthroscopic localization of the deposit is frequently demanding. The technique described in this article facilitates the localization of calcium deposits based on preoperative ultrasonography. Knowing the exact topography of the deposit relative to the visible landmarks allows the surgeon to localize the site of the deposit from the intra-articular view. Probing the rotator cuff with a spinal needle and looking for calcific material at the tip of the needle is an important step in verifying the location of the deposit.

Arthroscopy↗
PubMedDate not supplied

Benign giant-cell tumor of the patellar ligament.

We report the symptoms, clinical findings, and treatment of a patient with an extra-articular benign giant-cell tumor of the patellar ligament. Between the years 1966 and 1996 no similar case has been found to be documented by a Medline search. On palpation, a soft, mobile lesion, the size of a pigeon's egg, was felt in the lateral region of the patellar ligament. There was no set of laboratory values to determine the diagnosis. In addition, there were no typical findings in diagnostic imaging procedures and it seems that the most important fact is that the clinician is aware of this type of synovial tumor. A clear diagnosis is only possible by means of a pathological investigation. The choice of therapy for giant-cell tumors is local excision. Arthroscopy is recommended exclusively for the diagnosis and therapy of a localized intra-articular giant-cell tumor.

Adult↗
PubMedDate not supplied

[Improved radiological imaging of acetabular screw socket].

The improved radiological representation of the cementless acetabular screw-socket at two levels is of fundamental importance for the postoperative determination of position as well as for the judgement of an aseptic loosening. To improve the radiological representation two special radiographic techniques in the anterior-posterior as well as in the axial view have been examined on a human preparation of pelvis and have been scrutinized on a great number of clinical patients. The a.-p. radiography with twenty degrees cranio-caudal prone view in the sagittal plane and the axial radiography with forty-five degrees caudo-cranial prone view in the coronal plane shows the best and fewest overlayed representation of the screw-socket. The position of inclination and anteversion could have been directly determined out of these two radiographs. Malpositions of the screw-socket, especially with regard to the anteversion are easily identifiable due to the special axial radiographic technique. Overprojection of adjoining bone areas, which were possible should be considered at the judgment of the implant-bone-contact. Radiographic technical and positioning problems were not observed in patients. Out of these examinations the a.-p. radiography with twenty degrees cranio-caudal prone view in the sagittal plane and the axial radiography with forty-five degrees caudo-cranial prone view in the coronal plane could be recommended to the radiological diagnosis after implantations of hip prosthesis.

Acetabulum↗