Search PubMed⌕ Search

Biomedical subjects

D Koev

Publications and source records attributed to D Koev.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Basedow's disease in a female patient with breast cancer metastasizing to the thyroid].

A case is presented of a woman with a breast cancer who developed Basedow's disease several months after the diagnosis of the cancer. In spite of the antithyrotoxic treatment the Basedow's symptoms persisted till the end of life. The case is compared with other similar cases in which the combination of Basedow's disease with a metastatic tumour of the thyroid gland is not described. Probably the tumour invasion of the thyroid gland triggers the appearance of various clinical syndromes of hyperthyroidism including the full classical picture of Basedow's disease as is the case in the reported patient. The intimate etiopathogenetic mechanisms of these thyrotoxic syndromes are not yet clear.

Breast Neoplasms↗
PubMed1987

[Dissociation between absorption of 131I-19-iodocholesterol and hormonal activity in corticosteroma patients].

A case is described without clinical and hormonal data about Icenko-Cushing syndrome, with a scintigraphy of adrenals demonstrating the image, characteristic for corticosteroma (decompensated node). The most probable explanation of the finding is that the tumour is with restricted secretory possibilities and secrets mainly biologically inactive hormones, and furthermore it is not with an autonomous, but ACTH-dependent hormonal production.

19-Iodocholesterol↗
PubMed1986

[Autonomic innervation of the heart of young patients with insulin-dependent diabetes].

The autonomic innervation of the heart has been studied in 32 young patients with insulin-dependent diabetes mellitus and 28 controls by measuring the intervals PP of electrocardiograms at rest, deep breathing, stimulation of n. vagus according to Ashner method and after suppression of vagus tone by atropine. The orthostatic test was performed. The patients with diabetes were established to have a higher heart rate and less manifested variations of the intervals PP at rest. During deep breathing, the patients with diabetes also showed a poorer variability of the intervals PP as compared with the controls. The reactions, however, in both groups with Ashner test and orthostatic test, were similar. Asymptomatic sinoatrial block was recorded in a patient with diabetes by the method of Ashner. The study revealed that the autonomic innervation of the heart was oft disturbed in case of diabetes. There was a correlation between the severity of that disorder and diabetes duration, diabetic peripheral polyneuropathy established in all cases. The other manifestations of diabetic polyneuropathy are more rare and later observed. The disturbed autonomic innervation of heart activity could be responsible, in some cases, for the sudden cardiac death among the patients with diabetes.

Adolescent↗
PubMed1984

[Juvenile diabetic cheiroarthropathy].

A 16 years old male is described who was taken ill by diabetes mellitus at the age of 8, treated with insulin, 36 U daily, but with constant poor control of the diabetes. His soft tissues of hands and fingers got thickened in the course of the last several years, with restriction of articular movements and impossible full extent of active and passive extension. No clinical and laboratory data about inflammatory articular process were established. The necessity of a strict control of diabetes is stressed upon, both for the prophylaxis and treatment of juvenile diabetic cheiroarthropathy.

Adolescent↗
PubMed1979

Plasma renin activity in diabetic patients.

Plasma renin activity (PRA) in 40 diabetic patients and 42 healthy controls was investigated using the method of Pickens in modification of Serebrovskaja et al. (1967). PRA was slightly lower in the whole group of diabetes but the difference was not significant. The subgroup of 20 maturity-onset diabetics had significantly lower PRA in comparison with 22 controls of similar age, while PRA in juvenile diabetics did not differ significantly from matched controls. In patients without clinical signs and symptoms of microangiopathy PRA was as high as in the controls. In diabetics with microangiopathy PRA was significantly lower. PRA was also lower in patients with longer duration of the disease. The stimulation of juxtaglomerular apparatus with sodium free diet and diuretic drugs resulted in an increase of PRA both in controls and diabetics. This suggests a functional depression of PRA in diabetic patients. In diabetics with ketoacidosis PRA was higher than in control subjects and decreased after disappearance of ketoacidosis. A high level was recorded in a patient with hyperosmolar coma and a very low level in a patient with polyneuropathy and severe orthostatic hypotension. The possible mechanisms involved in the changes of PRA in diabetic patients are discussed.

Adolescent↗
PubMed1978

[Treatment of diabetic ketoacidosis by continuous venous infusion of small insulin doses].

The authors treated 60 patients with diabetic ketoacidosis by continuous venous drop insulin infusion with 8 U every hour during the first six hours and after the sixth hour--20 U every three hours. Rehydration was performed with physiological serum in case of glycemia over 200 mg% and with 5% glucose serum in glycemia under 200 mg%. The patients were led out of ketoacidosis in approximately 9 hours and 36 minutes, the blood sugar diminution being slow and gradual, without hypoglycemic incidence. The average total insulin dose used was 72 U. The authors recommend that method for the practice with a view to its simplicity, safety and high effectiveness.

Adolescent↗
PubMed1977

[Acromegalic cardiopathy].

A patient with acromegaly is described with a relatively small eosinophilic adenoma of the hypophysis, the cardiopathy standing out on the foreground of the clinical pictrire, due to which it has for a long time been interpreted as a primary cardiac ailment. The cardiac disorder proceeds with cardiomegaly, conductivity disturbances and left, quickly progressing into complete and resistant to treatment cardiac insufficiency. The problem of the origination of the so called primary cardiac insufficiency is discussed, resulting from the direct effect of STH upon myocardium.

Acromegaly↗
PubMed1975

[Simmonds-Sheehan syndrome].

A woman of 30 with Simmonds--Sheehan syndrome is described that developed after delivery by vacuum-extraction of the fetus, due to powerless labour. The clinical picture was dominated by suprarenal cortical insufficiency, manifested with pains in the abdomen, vomiting, hypotonia and severe asthenic-adynamic syndrome. The substitutional hormonal treatment completely restored the general state and the working capacity of the patient.

Adult↗
PubMedDate not supplied

[The phenotypic characteristics and incidence of dyslipoproteinemias in diabetic patients].

A total of 121 inpatients with insulin and noninsulin dependent diabetes mellitus were investigated. The patients with noninsulin dependent diabetes mellitus were divided into 2 groups with relation to the presence or absence of secondary resistance to sulfonyl urea derivatives. Changes in the plasma and lipoprotein concentration of cholesterol (ChS) and triglycerides (TG) were analyzed. According to the author's classification, changes in lipoprotein patterns were distributed in some phenotypes of dyslipoproteinemias (DLP) and their prevalence was studied among the examinees. DLPs were detected in 84.3% of the patients (59.8% were latent). The patients demonstrated a high frequency of hypocholesterolemia of very low density lipoproteins (57.8%) and hypertriglyceridemia of low density lipoproteins (31.4%). These intralipoprotein variations were shown to be the chief element of phenotypical characterization of II (c, d), IV (b, c) and VI (a, b, c) DLP types, not included in Fredrickson's classification.

Diabetes Mellitus, Type 1↗