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Biomedical subjects

D Knight

Publications and source records attributed to D Knight.

64 records · Page 4Linked to original sources
PubMed1979

A pilot study on left ventricular dimensions and wall stress before and after submaximal exercise.

Left ventricle dimensions and wall stress were measured echocardiographically before and immediately after exercise in 14 athletes and 7 control subjects. Our findings suggest that afterload is an important determinant of cardiac performance and wall hypertrophy in athletes. In spite of major changes in heart rate and blood pressure, left ventricular wall stress remains unchanged following submaximal exercise, in trained and untrained hearts. It would appear that the changes in heart size during exercise are to a large extent limited in untrained ventricles, as smaller left ventricular dimensions are required, to "normalise" wall stress. This results in a lower stroke volume for a given stroke dimensional change. Consequently cardiac output is a function of heart rate rather than stroke volume in untrained subjects. The effect of increased muscle mass in athletes, is to permit larger left ventricular dimensions for a given afterload, thus stroke volume can be augmented. The increase h/R ratio suggests that afterload is more important than preload in the development of left ventricular hypertrophy in rowers and swimmers.

Adolescent↗
PubMed1978

Lung water changes after thermal burns. An observational study.

Pulmonary extravascular water has been measured as lung thermal volume (LTV) in a group of nine burned patients. Transducer-detectable indicators were used to permit frequent repetition and quick results. Concurrent recordings were made of cardiac output, pulmonary capillary wedge pressure and the usual hemodynamic variables. Moderate elevation of LTV was seen in all, reaching a maximum value before peripheral edema formation was complete. Left heart filling pressures were low as plasma albumin concentration. Clinical pulmonary edema occurred in one patient treated mostly with crystalloid solution. In several, a secondary peak coincided with edema mobilization.

Adult↗
PubMed1975

Significane of intravascular coagulation in canine endotoxin shock.

The contribution of disseminated fibrin clot formation to the pathogenesis of canine endotoxin shock was explored in control dogs and in those defibrinated with a purified fraction of Malayan pit viper venom. The hemodynamic and humoral responses after the administration of an intravenous challenge dose of Escherichia coli endotoxin were comparable as was mortality. It is concluded that, although the role of the coagulation sequence in canine endotoxin shock is unclear, it does not appear to be determinative.

Animals↗
PubMedDate not supplied

Slipped upper femoral epiphysis--a review of 12 years of experience in Glasgow (1972-1983).

We conducted a retrospective study of 97 cases of slipped capital femoral epiphysis occurring in 77 children. Gradual epiphyseal slip frequently occurred, and complications were more frequent with greater degrees of slips. Diagnostic delay should, therefore, be avoided, and a high index of suspicion is necessary when adolescents with leg pain or limp are examined. Minor epiphyseal slip should be carefully fixed in situ, and we suggest that the remainder undergo a gentle manipulation. Only those hips with a persisting deformity need undergo femoral osteotomy.

Adolescent↗