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Biomedical subjects

D King

Publications and source records attributed to D King.

303 records · Page 17Linked to original sources
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Difference between influences of homologous and heterologous maternal antibodies on response to serotype-2 and serotype-3 Marek's disease vaccines.

Marek's disease (MD) vaccines representing serotypes 2 (SB-1 strain of MD virus) and 3 (FC-126 strain of turkey herpesvirus) were administered to 1-day-old MD-susceptible chicks that either were free of antibodies or carried maternally derived antibodies against SB-1, FC-126, or a serotype-1 MD virus, CU-2 strain. Homologous antibodies delayed the development of vaccine virus viremias and inhibited vaccinal immunity, as judged by protection against challenge with the virulent JM-10 strain of MD virus 7 days postvaccination. Heterologous antibodies had little effect on vaccine responses. Antibodies were shown to interfere with both cell-associated and cell-free vaccine virus.

Animals↗
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Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy.

A traumatic false aneurysm of the descending genicular artery developed as a complication of suction drainage of a knee following synovectomy in a patient with hemophilic arthropathy. The aneurysm enlarged in spite of Factor VIII replacement therapy, and surgical resection was required. As a precautionary measure, in knee arthrotomy operations, trocar-tipped catheters could be passed through the lateral side of the suprapatellar pouch.

Adolescent↗
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Atrial fibrillation in the elderly: physicians' attitudes to anticoagulation.

The use of warfarin and aspirin for the primary prevention of stroke in elderly patients with atrial fibrillation (AF) is controversial. To establish current practice we circulated a questionnaire to 300 geriatricians (G) and 300 cardiologists (C). The response rates were 47% G and 51% C. Most physicians prescribed warfarin in AF associated with mitral stenosis (G vs C, 86% vs 89%, NS). Cardiologists were more likely to prescribe warfarin in AF associated with dilated cardiomyopathy (G vs C, 52% vs 86%, P < 0.01). A minority would prescribe warfarin in aortic valve disease and AF (G vs C, 37% vs 24%, P < 0.05) and lone AF (G vs C, 10% vs 26%, P < 0.01). Aspirin was favoured in aortic valve disease and lone AF. The cardiologists were less reluctant to use warfarin in the young and more likely to electrically cardiovert the young with chronic AF.

Aged↗
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Geriatrics↗
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Survey of cardiac arrests and cardiac arrest trolleys in a district general hospital.

In a 12-month period there were 137 cardiac arrests in a district general hospital. Cardiopulmonary resuscitation was instituted within 3 minutes in 82%. Delay in 18% was due to equipment failure. Survival at 6 months was 12%. Of the 18% of inappropriate arrests, 42% had 'do-not-resuscitate' orders in the casenotes. Survival did not depend on age, sex, location, presence of an anaesthetist, experience of house officer, time of day or admission diagnosis. Survival was more likely in the presence of ventricular fibrillation and absence of intubation. Of the 32 arrest trolleys, 66% were geographically acceptable to the area they served and 9% had significant deficiencies (these were situated in patient waiting areas and were infrequently checked).

Adult↗
PubMedDate not supplied

Cardiopulmonary resuscitation training: where are we now?

The aim of this study was to assess the current situation with regard to cardiopulmonary resuscitation training and organisation 10 years after guidelines were published by the Royal College of Physicians. Questionnaires were sent to 100 UK hospital trusts (88 responses) and 200 general practitioners on Wirral, Merseyside (92 responses). Most trusts gave their staff annual training in CPR, but only 80% trained all staff who came into contact with patients. Not all trusts employed resuscitation training officers, carried out routine audit or had formal CPR policies. The majority of GPs had had no training in CPR for more than five years. Only one practice had a defibrillator, yet 14% had needed to carry out CPR in the past 12 months. Less than half the GPs ever discussed CPR with appropriate patients. The resuscitation service in this country is fragmented, and certain areas--particularly in the training of GPs--need attention.

Cardiopulmonary Resuscitation↗