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Biomedical subjects

D Kaye

Publications and source records attributed to D Kaye.

At least 163 records · Page 9Linked to original sources
PubMed1975

Probable postcardiotomy syndrome following implantation of a transvenous pacemaker: report of the first case.

The syndrome of fever and pericarditis is reported following implantation of a transvenous pacemaker in a 72-year-old man. The pacemaker was placed for prophylactic reasons (i.e., presence of bifascicular block). The syndrome resolved spontaneously after over four weeks of fever and a pericardial friction rub. Perforation of the right ventricle, although not recognized in this patient, is a complication which occurs with passage of a transvenous pacemaker. There was no other antecedent events to explain the syndrome such as myocardial infarction or trauma to the chest.

Aged↗
PubMed1975

Double-blind comparison of phlebitis produced by cefazolin versus cephalothin.

In a double-blind study with each patient as his own control, 1 g of cefazolin and 2 g of cephalothin were administered intravenously every 6 h to 20 patients in opposite arms for a period of 48 h each. The degree of phlebitis was significantly more severe with cephalothin than with cefazolin (P < 0.05); however, neither the incidence of phlebitis nor the time of onset of phlebitis was significantly different between the two drugs.

Adult↗
PubMed1975

Antagonism between chloramphenicol and penicillin in streptococcal endocarditis in rabbits.

Antagonism between chloramphenicol (CHL) and penicillin (PCH) was studied in rabbits with Streptococcus viridans endocarditis. PCN alone or preceded 1 hour by CHL was injected twice a day starting 6 hours or 3 days after infection. In animals treated 6 hours after infection, vegetations contained mean log colony-forming units (CFU):3.0 per gram in PCN animals and 3.7 in PCN + CHL animals (P greater than 0.05) after 24 hours of treatment and 2.4 in PCN animals and 4.3 in PCN + CHL animals (P greater than 0.01) after 48 hours. In animlas treated 3 days after infection, vegetations contained mean log CFU: 3.8 per gram in PCN animals and 5.2 in PCN + CHL animals (P greater than 0.01) after 72 hours of treatment and 1.7 in PCN animals and 2.5 in PCH + CHL animals (P greater than 0.05) after 5 days. The antibiotic antagonism demonstrated in these studies could be reduced by injecting CHL 1 hour after PCN instead of 1 hour before PCN.

Animals↗
PubMed1975

Host defense mechanisms in the urinary tract.

In most episodes of urinary tract infection bacteria reach the bladder through the urethra and then may ascend to the kidneys through the ureters. Bacteria periodically enter the female urinary bladder from the urethra in small numbers. Whether infection ensues depends on the virulence and inoculum size of the microorganism and the adequacy of most defense mechanisms. Human urine is frequently inhibitory and sometimes bactericidal for the bacteria that cause urinary tract infection. Inhibition of bacterial growth coupled with voiding serves as a very effective antibacterial defense mechanism. In addition an intrinsic antibacterial defense mechanism has been demonstrated in the rat urinary bladder unrelated to urine flow. The medulla of the kidney is much more susceptible to infection than the cortex mainly related to its high osmolality. Certain abnormalities of the urinary tract interfere with host defense mechanisms and therefore predispose to urinary tract infection or make infection more difficut to eradicate once present. Some of these abnormalities are obstructive or neurological diseases of the urinary tract, vesicoureteral reflux, calculi, certain metabolic, hematologic, and vascular diseases, and pregnancy.

Adult↗
PubMed1974

Single-dose daily gentamicin therapy in urinary tract infection.

Patients with urinary tract infection were treated for 8 to 15 days with one daily intramuscular injection of 160 mg of gentamicin or 60 or 80 mg every 8 h. Ten of 11 patients treated with one injection daily were cured as compared with 8 of 10 patients treated with three injections daily. Urinary concentrations of gentamicin were 3.2 to 600 mug/ml in all 8-h collections in patients receiving one injection daily and were 22 to 440 mug/ml in all 8-h collections in patients receiving three injections daily. The group treated once daily demonstrated a significant but reversible increase in mean serum creatinine concentration and decrease in mean creatinine clearance during therapy as compared with no change in the group treated with three injections daily. Decreases in renal function were correlated with higher milligram per kilogram doses and higher 1-h serum concentrations.

Adult↗