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Biomedical subjects

D Karcz

Publications and source records attributed to D Karcz.

At least 19 recordsLinked to original sources
PubMed2000

Long-term results of pancreatic cancer surgery.

Despite of growing incidence of pancreatic cancer and dynamic development of modern diagnostic methods, long-term treatment results are still unsatisfying. The aim of the study is the assessment of long-term outcome of pancreatic cancer surgery. Group of 621 patients hospitalized between 1972-1999 was analyzed. Pancreatic resection was performed in 34.1% (n = 212) patients, and in 65.9% (n = 409) cases a palliative bypass procedure was carried out. Increased number of resective procedures (from 6.2% to 40.1%) in the recent years was observed with lower perioperative mortality rates (from 20% to below 5%). The analysis of the long-term results of surgical treatment for pancreatic cancer showed significant improvement of the overall 5-year survival from 4.2% to 17.1% in the recent years. Based on the carried out analysis the authors conclude, that pancreatic cancer surgery performed by the experienced surgeon improves long-term results lowering to minimum the rates of complications.

Adult↗
PubMed1999

An immunohistochemical study of the expression of bcl-2 and p53 oncoproteins in pancreatic intraepithelial neoplasia and pancreatic cancer.

BACKGROUND: The bcl-2 and p53 gene deregulation is frequently involved in several types of malignancies. The purpose of this study was to evaluate the expression of bcl-2 and p53 genes in various types of pancreatic intraepithelial proliferation and in pancreatic cancer and to answer the question of whether they interact in the process of intraductal epithelial proliferation. METHODS: Immunohistochemical staining for p53 and bcl-2 was performed on paraffin embedded sections from 56 patients operated on for pancreatic carcinoma, chronic pancreatitis, and other conditions. RESULTS: Pancreatic cancer in 100% of cases showed p53 expression and in 27.7% bcl-2 expression. The p53 gene was expressed already in pancreatic intraductal neoplasia and its frequency was significantly rising with an increasing degree of hyperplasia. Normal epithelium of pancreatic ducts and ductules showed a high expression of bcl-2, which was decreasing in the process of intraductal proliferation. CONCLUSIONS: Pancreatic cancer is characterized by a high expression of p53 and a low expression of bcl-2. In pancreatic cancers and pancreatic intraepithelial neoplasia, there is an inverse relationship between the expression of bcl-2 and p53. Malignant behavior of pancreatic cancer may be associated with the phenotype bcl-2-/p53+.

Carcinoma↗
PubMed1997

Efficacy of ebrotidine and ranitidine combined with amoxicillin and metronidazole in the eradication of Helicobacter pylori in patients with duodenal ulcer.

This double-blind, randomized, phase III clinical trial was carried out in two parallel groups to assess the efficacy of ebrotidine (N-[(E)-[[2-[[[2-[(diaminomethylene) amino]-4-thiazolyl]methyl]thio]ethyl]amino] methylene]-4-bromo-benzenesulfonamide, CAS 100981-43-9, FI-3542) 400 mg and ranitidine 300 mg given in single evening dose, combined with amoxicillin 750 mg and metronidazole 500 mg three times daily for 14 days, in the eradication of Helicobacter pylori in patients with duodenal ulcer. Thirty patients were included, divided into two groups of 15, to whom one of the study therapies was administered based on a randomization code. Clinical and endoscopic controls were performed 4, 6 and 8 weeks after the onset of the treatment. No differences were seen between the two treatment groups with regard to demographic parameters and clinical histories. They were both perfectly homogeneous. There were no differences between the eradication of both therapies in both the antrum and gastric body samples (over 80% eradication), allowing the results to be classified as satisfactory. Moreover, perfect control was achieved through the study of clinical symptoms, which even disappeared in some cases. There were no differences in the healing rate of the duodenal ulcer after four weeks, 86.7% being achieved for both groups.

Adult↗
PubMed1993

Long-term results of highly selective vagotomy in the treatment of duodenal ulcer patients using the intra-operative endoscopic congo red test to identify the parietal cell antrum-corpus borderline.

A total of 151 patients with uncomplicated duodenal ulcers were treated with highly selective vagotomy. The patients were subsequently observed prospectively for a period of 3-17 years. The recurrence rate for the whole group reached 4.6%. The parietal cell antrum-corpus borderline for denervation was marked using the intra-operative endoscopic Congo Red Test. The test was useful for the classification of patients into the group (own method) and for the identification of patients with "acid antrum". Between 1974-1980, Highly selective vagotomy was performed in 93 patients in some of whom single clusters of parietal cells were diagnosed in the prepyloric region (acid antrum, type A). The recurrence rate in this group reached 7.5%. In a group of 58 patients operated on after 1980 from which "acid antrum" cases were eliminated, no recurrences have so far been observed. Additionally, the results of early and late complications and the results of patient self-estimation using to Visick's scale are discussed.

Adolescent↗
PubMed1987

Endoscopic sphincterotomy as a therapeutic measure in cholangitis and as prophylaxis against recurrent biliary tract stones.

Our purpose was to analyse the results of endoscopic sphincterotomy in patients with advanced cholangitis, and to assess the potential of this method in the prevention of recurrent biliary tract stones. Advanced cholangitis certainly predisposes to microlith formation, and we believe that the increased biliary drainage produced by sphincterotomy counteracts this process. Our grading of cholangitis was an intraoperative cholangioscopic assessment corresponding to Nishimura grades III and IV (erosions in the duct walls, patchy stone ulceration, biliary gravel, fibro-purulent plaques densely adherent to the biliary walls etc. 62 patients with grades III and IV cholangitis (as defined at choledochoscopy) underwent endoscopic sphincterotomy (GP-A). This group underwent a controlled prospective study with review at: one year, between 2 and 3 years, 5 years following surgery. The control group (GP-B) constituted 20 patients with comparable cholangitis who did not undergo sphincterotomy. Group A had no recurrent lithiasis, 4.8% revealed persistent cholangitis. In control group (GP-B) 6 patients (30%) revealed recurrent lithiasis, on average 4.6 years following initial surgery. In addition, 35% of this group had clinical symptoms of cholangitis. These results indicate that endoscopic sphincterotomy is a worthwhile method in the treatment of cholangitis and prophylaxis against recurrent biliary tract stones.

Ampulla of Vater↗
PubMed1981

[Results of subjective and endoscopic studies on the incidence of upper digestive tract pathology among industrial workers].

This paper has been aimed at an evaluation of the prevalence of upper alimentary duct pathologies in an industrial population, as well as at an attempt to evaluate the value of subjective symptoms in screening tests. Altogether 975 subjects have been examined, but only 235 of them underwent endoscopic studies. The data on subjective symptoms have been collected from all the subjects, by way of a special questionnaire. In the group of those subjected to endoscopic studies, 38,7% have been found to have developed various diseases of the upper alimentary duct. Those predominating have been ulcers and deformations of pylorus and hiatal herniae. Ulcers and deformations of duodenum in smokers have been nearly twice those in nonsmokers. The results demonstrated that the prevalence of upper alimentary duct diseases in the industrial population concerned, has been higher than expected. To account for this, further epidemiological analytical studies must be undertaken. It has been found that within the screening studies of populations, aimed at the detection of upper alimentary duct diseases, questionnaire on abdominal pain is more reliable than the questions on dyspeptic symptoms.

Adult↗