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Biomedical subjects

D Kaplan

Publications and source records attributed to D Kaplan.

At least 181 records · Page 10Linked to original sources
PubMed1978

Diagnosis and management of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is not a rare disease. There are several common clinical signs which should alert the physician to a possible diagnosis of SLE and which should condition him to look for specific clinical and laboratory findings. In addition to simple screening tests, useful procedures include a search for antinuclear antibodies, lupus erythematosus (LE) cells, anti-DNA antibodies and low serum complement. Management is determined by the type of course encountered but most patients will do well under the care of their family physician.

Adult↗
PubMed1977

Pulmonary function in scleroderma.

Pulmonary function tests were performed in 45 patients with scleroderma. Thirteen patients (29%) were found to have restrictive disease, 12 patients (27%) were found to have obstructive disease, and 19 patients (42%) had small airway disease (SAD). Smoking did not seem to be a factor underlying either obstructive or small airway disease in these patients. A low diffusing capacity was most common in patients with restrictive disease and rarely the only abnormality in pulmonary function. SAD was usually found in patients who had normal chest radiographs and no pulmonary symptoms and was often the only abnormality. SAD is therefore an early and sensitive indicator of pulmonary involvement in scleroderma.

Adult↗
PubMed1977

Abelson virus-transformed lymphocytes: null cells that modulate H-2.

A-MuLV-transformed lymphoid cells from Balb/c mice had the properties of null lymphocytes. They did not secrete Ig and all but one did not have detectable cell-associated Ig; one line synthesized, but did not secrete, the mu chain of IgM. The cells expressed H-2D and H-2K, but not H-21 histocompatibility antigens or theta-antigen; they had Fc receptors. Most cell lines grew to form donor cell tumors after inoculation into (Balb/c X C57B1/6)F1 mice. The tumor cells have more H-2Dd than cells passaged in vitro. Cell lines carried in vitro progressively lost H-2Dd. A line in which 5-30% of the cells were lysable by anti-H-2Dd was cloned; all eleven clones had H-2Dd (13-69% lysable) demonstrating that H-2 modulates in vitro. A clone with little H-2Dd (10-15% lysable) was tumorigenic even after treatment with anti-H-2Dd sera; at least 50% of the tumor cells were lysed by anti-H-2Dd. Thus A-MuLV-transformed lymphocytes modulate H-2 in vivo to higher levels and in vitro to lower levels.

Animals↗
PubMed1977

Eating in public places: a review of reports of the direct observation of eating behavior.

A review of 13 studies of the direct observation of eating was undertaken in an effort to learn what these studies tell us about the causes and control of obesity. The studies assessed several measures of eating behavior but few of them assessed the same measures. There was no agreement about a distinctive 'obese eating style', but two measures showed promise in discriminating obese from non-obese persons. The first was food choice: obese persons chose more food than non-obese persons (and men chose more than women and tall persons more than short ones). The second measure was rate of eating: obese persons consumed more food per minute than non-obese persons. The studies point up the remarkable plasticity of human eating behavior and the wide range of factors which influence it. This plasticity has profound implications for both research and therapy. It means that only unusual care in the identification and control of extraneous variables will permit adequate assessment of the variables under investigation. Its second implication is as important: if eating is so dependent upon environment, it may be easier to modify than previously thought.

Feeding Behavior↗
PubMed1977

Colchicine in the treatment of scleroderma.

We treated 10 patients with well established scleroderma with colchicine in the highest tolerated dose for one year. We could determine no clinical or laboratory improvement in any patient. Progression of disease was suggested by the development of new skin ulcers and telangiectasia, by an increase in musculoskeletal complaints, and by a significantly diminished ability to make a fist. In addition, there was deterioration of pulmonary function as demonstrated by a statistically significant fall in FEV1, and diffusing capacity. Colchicine was not of value in the treatment of scleroderma in this group of patients.

Adult↗
PubMed1976

Effect of serum on phospholipids of L-forms of Streptococcus faecalis.

Changes in the phospholipids of the membrane of L-forms of Streptococcus faecalis were studied after exposure to normal human serum. The phospholipids were labeled by incubating the L forms with [14C]palmitate. After the reaction of the L-forms with normal human serum, the percentage of total lipid radioactivity decreased in phospholipids and increased in free fatty acids, indicating phospholipase activity. Similar changes were seen on reacting normal human serum with autoclaved L-forms. Sonication of the L-forms resulted in only a slight increase in phospholipase activity. These results suggested that a major part of the phospholipase activity was in the serum.

Enterococcus faecalis↗
PubMed1975

Bisulfite induced lipid oxidation.

Bisulfite (0.5 to 10 millimolar) initiates oxidation of lipids in aqueous emulsions of corn oil in a dose-dependent manner as measured by reaction with thiobarbituric acid. The reaction is effectively quenched by the antioxidant, 2,6-dit-butyl-4-hydroxymethyl phenol as well as by Mn+2 (10(-5)-10(-3)M). The latter observation is in disagreement with that reported by others and suggests that in case of lipids an alternative mechanism exists for the initiation of reactive species.

Antioxidants↗