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Biomedical subjects

D Kahn

Publications and source records attributed to D Kahn.

321 records · Page 18Linked to original sources
PubMedDate not supplied

Is there a regeneration stimulator substance in the effluent from perfused partially hepatectomized livers?

An attempt was made to transfer a stimulator substance from the perfusate of partially hepatectomized perfused livers to the portal stump of portacaval-shunted pig recipients. Blood was either cross-circulated with recipients during perfusion or was given by exchange transfusion after 4 hr perfusion. There was an increase in thymidine kinase activity and mitotic indices in biopsies from portacaval-shunted recipients whether perfusions were performed 2 or 4 days after partial hepatectomy. Blood perfused through intact livers did not enhance the regenerative response of portacaval-shunted pigs; in fact it appeared to suppress the normal small response. Approximately 10% of the portacaval-shunted recipients died acutely when perfusate was infused into the portal stump. This did not occur if saline or unperfused blood was used suggesting that some toxic substance accumulated during liver perfusion. In end-stage fulminant hepatic failure, use of blood perfused through a partially hepatectomized animal liver may provide the regenerative stimulus which often appears to be lacking.

Animals↗
PubMedDate not supplied

Quantitative approaches to the analysis of the control and regulation of microbial metabolism.

Recently, a number of novel ways of considering the control, regulation and thermodynamics of microbial physiology have been developed and applied. We here present an overview of the new concepts involved, of their limitations and of the most recent attempts to deal with those limitations. We conclude that there no longer exist reasons of principle for vagueness in discussions of the control of microbial physiology and energetics. Further, the novel conceptual methods serve to remove part of the discordance between holistic and reductionistic views of microbial physiology.

Adenosine Monophosphate↗
PubMedDate not supplied

Evaluation in an inpatient setting of DTREE, a computer-assisted diagnostic assessment procedure.

This study examined the procedural validity of DTREE, a microcomputer-based expert system that guides the user through the diagnostic logic of DSM-III-R. A DTREE-guided DSM-III-R diagnosis of 20 inpatients (made by the treating clinician) was compared with a "standard" diagnosis made simultaneously during a weekly 2-hour case conference consisting of a presentation by the treating clinician and other staff, a chart summary, and the administration of the Structured Clinical Interview for DSM-III-R (SCID), and culminating in a group consensus diagnosis. The kappa agreements were .80 for schizophrenia (N = 10), .83 for major depression (N = 3), and -.08 to 1.00 for other disorders. These results suggest that DTREE can produce valid assessments, at least in an acute setting of primarily patients with schizophrenia.

Adolescent↗
PubMedDate not supplied

Combined retinal-retina pigment epithelial hamartoma presenting as a vitreous hemorrhage.

A 2-year-old healthy white boy had a vitreous hemorrhage in the left eye but no history or external signs of trauma. Computed tomographic and ultrasonographic examinations were not diagnostic. A pars plana vitrectomy performed when the patient was 2 1/2 years old revealed a posterior pole lesion diagnosed clinically as a combined retinal-retina pigment epithelial hamartoma. Such lesions may be symptomatic because of decreased vision, macular puckering, and strabismus; vitreous hemorrhage has not previously been reported as the presenting clinical sign or the predominant cause for reduced vision.

Child, Preschool↗