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Biomedical subjects

D K Ziegler

Publications and source records attributed to D K Ziegler.

At least 73 records · Page 4Linked to original sources
PubMed1981

Posttetanic potentiation in a patient with myasthenia gravis.

We studied a patient with clinically typical myasthenia gravis (MG) and high serum titer of antibodies to acetylcholine receptor. Unlike the usual response in MG, there was an increment in the amplitude of the electrical response (308% of control) after 10 seconds of voluntary tetanus. Posttetanic facilitation is usually less than 200% in MG and over 200% in Eaton-Lambert syndrome. However, there have been several other cases of typical MG with increments over 200%. Facilitation of this magnitude has also been seen with curare administration in animals and man. However, in myasthenia, as opposed to curare poisoning, competitive blocking is not thought to exist.

Autoantibodies↗
PubMed1981

Syncope problem solved by continuous ambulatory simultaneous EEG/ECG recording.

In a case of repeated syncope of abrupt onset and questionable origin, we utilized the continuous ambulatory cassette recorder to document simultaneous electroencephalography/electrocardiography (EEG/ECG) changes. Recording during a spontaneous episode established the cardiogenic origin. Problems in differential diagnosis of syncope and seizure are discussed. With this new instrument, if the initial event in ECG abnormality (as in the present case), further cardiologic study is indicated. If epileptiform EEG activity is primary, neurologic investigation is the direction to pursue; if there is nonepileptiform EEG slowing without ECG abnormality, diagnosis of syncope of noncardiac origin (e.g., hypotension, hypoglycemia) should be considered.

Adolescent↗
PubMed1979

Circadian rhythms of plasma cortisol in migraine.

Diurnal rhythm of plasma cortisol, of psychological state, and of pain was measured for two days in 25 migraine patients and eight control subjects. Fourteen of the migraine patients and none of the controls displayed either consistently high plasma cortisol or an occasional aberrant peak. Abnormal psychological findings, particularly depression, were found in the Minnesota Multiphasic Personality Inventory only in migraine patients with abnormal plasma cortisol levels. Neither psychological abnormality nor pain seemed the single cause of elevation of plasma cortisol.

Adult↗
PubMed1978

Tension headache.

Headache is an extremely common symptom, and many headaches undoubtedly have a relationship to stressful situations. The clear definition, however, of a "tension headache" complex and its differentiation from migraine in some patients is difficult. The problems are in the identification of a specific headache pattern induced by stress or "tension" and the relationship of the symptom to involuntary contraction of neck and scalp muscles. Treatment consists of analgesics and occasionally mild tranquilizers. Psychotherapy consists of reassurance and often other supportive measures, including modification of life styles. Various feedback techniques have been reported of value, but their superiority to suggestion and hypnosis is still problematic.

Headache↗
PubMed1978

Recurrent Guillain-Barré syndrome following influenza vaccine.

Two patients recovered from an attack of Guillain-Barré syndrome and then had a second attack of this disease, with a shorter latent period, following monovalent influenza vaccination. These cases suggest that an attack of Guillain-Barré syndrome may result in greater risk of future episodes of the syndrome in conjunction with exposure to influenza or other vaccinations.

Adult↗
PubMed1978

Association of psychological measurements of anxiety and depression with headache history in a non-clinic population.

In a group of 711 non-clinic individuals, a self-administered questionnaire gave data on the life history of headache of defined severity and psychological states as defined by the Zung SDS and the Bendig-Taylor test. When the population was divided into those with and those without a history of disabling or severe headache, significantly higher scores for the former were found on both 'anxiety' and 'depression' tests--for both sexes, at all ages. Zung SDS scores fell from youth to middle age, then rose in old age. When the frequency and duration of headache were studied in association with psychological tests, the most significant association was found between headache frequency and depression scores.

Adolescent↗