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Biomedical subjects

D K Sen

Publications and source records attributed to D K Sen.

At least 37 records · Page 2Linked to original sources
PubMed1986

Serum fibrin degradation products in acute idiopathic anterior uveitis.

Levels of serum fibrin degradation products were measured by the Staphylococcal clumping test in patients with acute idiopathic anterior uveitis and traumatic anterior uveitis. We found them to be significantly increased (P less than 0.001) in patients with acute idiopathic anterior uveitis (11.0 micrograms/ml). The extent of this increase in the serum levels of fibrin degradation products correlated well with increased severity of the disease. It showed return to normal levels (5.0 micrograms/ml) with the clinical improvement. It increased again with the re-appearance of acute stage of the disease. We found no alteration in the levels of serum fibrin degradation products in patients with traumatic anterior uveitis. We hypothesise that uveal deposition of immune complexes causes secondary platelet damage and intravascular coagulation which results in uveal tissue damage through inflammation.

Acute Disease↗
PubMed1986

Biological variations of lysozyme concentration in the tear fluids of healthy persons.

Concentration of tear lysozyme was measured in healthy Indian subjects of the same racial group aged 2 to 78 years by a single radial immunodiffusion technique. Variations in its concentration between the two eyes, during the day, over a period of time, in both sexes, and in different age groups were studied. The diurnal and age-related changes in the concentration of tear lysozyme were found to vary to an appreciable extent. The mean lysozyme concentration in tears was lower in the morning and higher in the evening. It tended to be low in children under 16, rose and attained a plateau in the age group 16-45 years and fell in later life, though still remaining higher than in the children.

Adolescent↗
PubMed1985

Serum complement components in patients with trachoma.

Serum C1q, C3, C4, and C5 components of complement levels were measured in 56 healthy subjects and 98 patients with trachoma. Serum C1q and C3 levels were found to be significantly low in stages II and III. There was no change in serum C4 and C5 levels in any of the stages. The levels of C1q and C3 complement components in serum in stages II and III returned to normal as the disease resolved following the medical treatment.

Adult↗
PubMed1985

A multicenter randomized comparative investigation of ML Cu250, TCu-220C and Cu7 IUDs.

The final analysis of 1725 interval insertions of the 3 IUDs is presented. The earlier observations were confirmed at: at 24 months, no significant differences were found between the TCu-220C and ML Cu250 IUDs though the TCu-220C had a lower gross pregnancy rate (2.0 versus 2.9) and the ML Cu250 had a lower expulsion rate (2.3 versus 4.1). Expulsions were more common with the Cu7 when compared to the ML Cu250 (p 0.001) and T-220C (p 0.01); pregnancy rates were also higher with p values of 0.05 and 0.01 respectively. Other use-related terminations were not significantly different among the 3 IUDs and continuation rates at 24 months were: Cu7, 69, TCu-220C, 73, and ML Cu250, 74.

Birth Rate↗
PubMed1984

Results of treatment in amblyopia associated with unilateral high myopia without strabismus.

Fifty-five patients with amblyopia in unilateral high myopia without strabismus were treated. Thirty-two (58%) had a visual improvement by two lines or more on the Snellen chart and 17 (31%) attained a final visual acuity of 6/12 or better. In patients with pretreatment corrected vision of 6/60 or better in the amblyopic eye treatment consisted of full-time occlusion of the good eye, in some cases supplemented by the after-image method of pleoptic exercises in the amblyopic eye. Overall improvement of vision in this group was 72.7%. Occlusion of the good eye combined with pleoptic exercises in the amblyopic eye had no advantage over simple occlusion of the good eye. In patients with pretreatment corrected vision worse than 6/60 in the amblyopic eye occlusion of the amblyopic eye was done and the after-image method of pleoptic exercises was instituted. Improvement of vision in this group was 36.3%. The study showed that it is worth the trouble to treat this disorder even after the age of 14 years and stresses the utility of pleoptic therapy in older patients with severe amblyopia.

Adolescent↗
PubMed1984

Effects of maternal streptozotocin-diabetes on fetal growth, energy reserves and body composition of newborn pigs.

Two doses of Streptozotocin (50 and 100 mg/kg body weight) were administered to two groups of pregnant gilts at d 80 of gestation to determine the influence of two levels of maternal diabetes on the gilts, their developing progenies and the body composition of the pigs. All the experimental animals received 1.82 kg of gestation diet/day throughout gestation. Serum glucose concentration increased to hyperglycemic levels in low-dose and high-dose groups; insulin concentrations decreased (P less than .01) in the high-dose, but not in the low-dose group (P greater than .05). Maternal free fatty acids (FFA) increased (P less than .05) in both treatment groups when compared with the control. However, birth weight of the litter and litter size were not affected. The liver weight increased (P less than .01) in the progeny of high-dose but not the low-dose group. Total liver DNA and RNA were not altered by the treatments, however; total liver protein and protein:DNA ratio increased (P less than .01) in the progeny of high-dose gilts. Pigs from high-dose and low-dose groups showed increases (P less than .01) in liver glycogen concentrations and percentage liver lipid. Body chemical composition data showed increases in percentage dry matter and percentage lipid (P less than .05 and P less than .01, respectively) in the progeny of high-dose but not in the low-dose group. It was concluded that streptozotocin administered to gestating gilts increased the maternal nutrient supply to the developing pigs, which resulted in higher energy status of the pigs at birth.

Animals↗
PubMed1983

A randomised comparative evaluation of the copper 7, multiload copper 250 and T copper-22OC IUDs.

Two new Cu-IUDs, the TCu-22OC and Multiload Cu250, were evaluated against the Cu7 in 1,199 subjects in a randomised, multicentric trial using a common study protocol. During the 2 years following insertion, cumulative first-segment rates for total use-related terminations showed no significant differences between the 3 devices; however, the Cu7 had a significantly higher termination rate for accidental pregnancy compared to the TCu-22OC and its expulsion rate was significantly higher than the ML Cu250. The rate of accidental pregnancy was higher and the expulsion rate lower with the ML Cu250 compared to the TCu-22OC but these differences were not significant. The results are discussed in relation to IUD design and their application in family planning.

Adult↗
PubMed1982

Results of treatment of anisohypermetropic amblyopia without strabismus.

One hundred and two patients with anisohypermetropic amblyopia without strabismus were studied. Microstrabismus was excluded by detailed orthoptic examinations including visuscopy and Cüppers' bifoveal correspondence test. Treatment consisted in wearing correcting glasses and part-time or full-time patching of the nonamblyopic eye. In patients with dense amblyopia patching of the amblyopic eye was done and Cüppers' after-image method of pleoptic therapy was instituted as the initial procedure. When visual acuity improved sufficiently by this therapy, patching was used on the nonamblyopic eye. Sixty-five (63.7%) patients showed 2 lines or more improvement on the Snellen chart. Though young children (6 to 12 years) improved their visual acuity more often than those aged 13 to 20 years, a considerable number of patients (50.0%) in the older age group improved their visual acuity after therapy. The improvement in visual acuity was accompanied by improved stereoacuity in 49.0% of the patients. It is therefore suggested that every effort should be made to treat these patients even after the age of 12 years.

Adolescent↗
PubMed1982

Immunoassay of tear lysozyme in conjunctival diseases.

The tear lysozyme content in 111 normal subjects and in 159 patients with various conjunctival diseases was determined by a single radial immunodiffusion technique. Tear lysozyme level in normal people was 1.33/mg/ml. (SI conversion: mg/ml = g/l.) The mean tear lysozyme levels in patients with chronic irritative conjunctivitis (0.97 mg/ml) and nutritional deficiency with epithelial xerosis (0.76 mg/ml) were significantly lower than in the normal controls. The mean tear lysozyme levels in tears from patients with vernal conjuctivitis (1.20 mg/ml), phlyctenular conjunctivitis (1.10 mg/ml), and acute bacterial conjunctivitis (1.48 mg/ml) were not significantly different from those in the normal controls. Superimposition of acute bacterial conjunctivitis on trachoma did not alter the low tear lysozyme level that existed before in these patients.

Adolescent↗
PubMed1982

Tear lysozyme in lepromatous leprosy.

Lysozyme concentrations have been estimated in 47 patients with lepromatous leprosy and in 50 healthy people by a single radial immunodiffusion technique using monospecific antiserum against human lysozyme. In healthy people the mean tear lysozyme concentration was 1.34 mg/ml. In leprosy patients the mean tear lysozyme concentration was 1.0 mg/ml. Anterior uveitis per se did not appear to alter the lysozyme concentration in tears.

Female↗
PubMed1982

Termination of pregnancy in cases of intrauterine fetal death, missed abortion, molar and anencephalic pregnancy with intramuscular administration of 2a 2b dihomo 15(S) 15 methyl PGF2 alpha methyl ester--a multicentre study.

2a 2b dihomo 15(S) 15 methyl PGF2 alpha methyl ester (dihomo 15 me PGF2 alpha) in intramuscular doses of 0.5 mg 8 hourly was used in 631 patients with abnormal intrauterine pregnancy comprising 282 cases of intrauterine fetal death, 233 cases of missed abortion, 34 and 82 cases respectively anencephalic and molar pregnancies. The study was carried out as a collaborative project between the University Departments of Obstetrics and Gynaecology in Singapore (Singapore), Medan (Indonesia) and Kuala Lumpur (Malaysia) during the period June 1974 and November 1979. Six hundred patients (95.1%) aborted or delivered in a mean time of 11.3 hours (S.D. +/- 7.0) with an average of 1.8 injections of the prostaglandin analogue per patient. Side effects included vomiting (23.6%; mean 0.45 episodes per patient), diarrhoea (44.4%; mean 1.00 episode per patient), cold and shivering (11.9%) and pyrexia (12.4%). One patient sustained a cervical laceration which did not require repair. There were no complications.

Abortion, Missed↗
PubMed1981

Effect of holothurin on Trypanosoma musculi infection in three strains of mice.

The effect of holothurin (a marine biotoxin) on the resistance of mice to trypanosoma musculi was measured by studying changes in the parasite population in vivo. Swiss Webster (SW), Beige (BG), and Black (BL) mice treated with holothurin prior to and simultaneously with infection of trypanosomes had lower parasitemias than controls. Higher levels of parasitemia were observed in mice treated after infection with trypanosomes. The timing of administration of holothurin appeared to be an important factor in the observed effect. The minor variations in the parasitemia seemed to be related to the mouse strain.

Animals↗