Biomedical subjects

D K Lovell

Publications and source records attributed to D K Lovell.

4 recordsLinked to original sources

PubMed1985

Exercise physiology. An overview.

Through the study of equine exercise physiology, one can learn more about what happens to the body of the performance horse during all forms of exercise. Better understanding of skeletal, joint, tendon, and ligament adaptations to loading and stress may allow adjustments to be made in training techniques to reduce the incidence of injury. The information obtained from exercise research may also facilitate the investigation of questions such as the following: What makes one horse perform better than another? How can one bring out the optimal performance in each horse? How can one tell when a horse has arrived at its peak performance capability? What are the factors that actually limit performance?

Adenosine Triphosphate↗

PubMed1981

A protracted case of cryptococcal nasal granuloma in a stallion.

A 13-year-old Standardbred stallion presented with a unilateral mucopurulent nasal discharge and airway obstruction was found to have an extensive cryptococcal nasal granuloma. Treatment was not attempted. The stallion was destroyed 26 months later having completed 2 successful breeding seasons. The granuloma had gradually increased in size and almost completely occupied the left nasal cavity and paranasal sinuses. It was characterised histologically by fibrous and myxomatous tissue and masses of yeasts. A cryptococcal granuloma found within the wall of the jejunum could represent evidence of dissemination, and organisms were seen within alveoli, bronchioles and the intestinal lumen.

Animals↗

PubMed1980

Effects of d-amphetamine and diazepam on paired and grouped primate food competition.

Two male and two female rhesus monkeys (Macaca mulatta) were the subjects of an experiment designed to assess the effect of d-amphetamine (DA; 0.125, 0.5 and 2.0 mg/kg, IM) and diazepam (DZP; 0.5 and 2.5 mg/kg, IM) on food-getting behavior in paired and group competition. Paired competition results show that in some cases submissive animals, that had previously failed to obtain apple pieces, were successful in obtaining some apple pieces when either the dominant animal of the pair or both subjects were given 0.5 mg/kg DA or 2.5 mg/kg DZP. Results revealed the same effect when all animals (group competition) were given 0.125 and 2.0 mg/kg DA and 2.5 mg/kg DZP. These results appear to indicate that the effect of drugs on food-getting behavior in competitive situations is in some manner influenced by the social status of the animal.

Animals↗

PubMed1980

The anorexic and actometric effects of cocaine and two coca extracts.

The effects of cocaine and two extracts of the coca leaf were compared using locomotor activity and limited access food consumption paradigms. The three treatments were tested using both IP and PO routes of administration. The extracts were prepared by first extracting the powdered leaves with 95% ethanol, evaporating the ethanol and then partitioning the residue between water and chloroform. The doses of the extracts studied were 60, 120, 240, and 480 mg/kg. The doses of cocaine studied were 3.45, 6.9, 13.8 and 27.6 mg/kg. These doses corresponded to the amount of cocaine contained in the four doses of the chloroform layer. Cocaine and the chloroform layer (via both routes) produced dose related increases in locomotor activity and dose related decreases in food consumption. The water layer (containing only trace amounts of cocaine) produced no changes in locomotor activity; however, the highest IP dose did significantly reduce food consumption. Furthermore two of the doses (one IP, one PO) of the chloroform layer produced significantly greater effects than an equivalent amount of cocaine. These data suggest that plant constitutents other than cocaine may contribute to the overall effect achieved by chewing the leaf.

Animals↗