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Biomedical subjects

D K Gupta

Publications and source records attributed to D K Gupta.

At least 127 records · Page 7Linked to original sources
PubMed1992

An epidemiological study of G-6-PD deficiency, sickle cell haemoglobin, and ABO blood groups in relation to malaria incidence in Muslim and Christian communities of Kheda, Gujarat, (India).

783 blood samples for the study of distribution of ABO blood groups and sickle cell haemoglobin in relation to malaria, from both the sexes of Muslim and Christian populations of Kheda district were screened. 414 blood samples from male individuals were screened for G-6-PD deficiency. High frequency of G-6-PD deficiency was observed in Christians (5.9%) and low in Muslim (1.8%) population, whereas sickle cell haemoglobin in Muslim population was 1.5% and absent in Christians. Blood group B was dominant in both the communities. Significant association of ABO polymorphs with P. falciparum and total malaria cases was observed.

ABO Blood-Group System↗
PubMed1992

Intradomestic mosquito breeding sources and their management.

Seven mosquito species were found to breed in intradomestic breeding sources. An. stephensi and An. subpictus bred in almost all types of containers. Among the culicines, Cx. quinquefasciatus and Ae. aegypti were predominant. Larval breeding was controlled through source reduction or introduction of larvivorous fish Poecilia reticulata. Health education helped in acceptance of the programme by the community. Intradomestic breeding positivity was 2-6% and 16-31% in experimental and control areas respectively.

Aedes↗
PubMed1992

Sensitivity of mosquito-pathogenic bacterial strains to various antibodies.

Four strains of Bacillus sphaericus, 1593, 2362, 9001 and 9002, B. thuringiensis H-14 and B. thuringiensis neoleonensis were tested for sensitivity against 18 antibiotics. The results revealed that all the four strains of B. sphaericus are resistant to colistin, nalidixic acid, polymyxin B and streptomycin. However, B. thuringiensis H-14 was resistant to 9 antibiotics, viz. ampicillin, cephalexin, carbenicillin, co-trimoxazole, colistin, cloxacillin, penicillin, nitrofurantoin and polymyxin B whereas B. thuringiensis neoleonensis was found to be resistant to 8 antibiotics. These results may help in isolation of potential and resistant mosquito pathogenic bacteria.

Animals↗
PubMed1992

Gujarat model of health management information system with reference to malaria.

The Gujarat model of health management and information system has been developed with the objective of reducing the work load of health workers at all levels pertaining to record keeping and report preparation for enhancing the quality of health services, as well as for better implementation and timely monitoring of health programmes. Pro formas currently in use under various health programmes have been reorganized and updated. For monitoring malaria, the total number of registers has been reduced from seven to one, reporting forms from 23 to six and the number of columns in reporting forms from 493 to 59. The model is expected to save the working time of laboratory technicians (15%) and multi-purpose health supervisors (5%) at PHC level and of all workers (100%) engaged in report preparation at district, state and national levels. The data generated by using this model are expected to be of high quality and accuracy and should lead to more rational planning.

Humans↗
PubMed1992

Microscopic diagnosis of malaria in Kheda district of Gujarat.

A study conducted in 1990 revealed that 2% (range 0.6-4.8) of negative blood smears were mislabelled as positive, and 6.7% of positive blood smears were mislabelled as negative. A result of such mislabelling would be inadequate treatment of a large number of patients. Hence the need to look into the training aspect and system of supervision of laboratory technicians. The present system of cross-checking of blood smears at different levels also needs to be reviewed. A study which could address itself to these needs is indicated.

Adult↗
PubMed1992

Role of ultrasound guided percutaneous antegrade pyelography (USPCAP) in the diagnosis of obstructive uropathy.

Ultrasound guided percutaneous antegrade pyelography (USPCAP) was performed in 6 cases between 1 month and 8 years age, presenting with obstructive uropathy. The procedure in this age group was characterized by (i) ease of performance without sedation in the neonates and with sedation in older children, and (ii) use of smaller needles and catheters. The procedure enabled delineation of the intimate anatomy of complicated urological abnormalities such as obstructed duplex system, primary megaureters, posterior urethral valves, prune belly syndrome, obstructive hydronephrosis and vesicoureteric reflux. Percutaneous renal puncture may be established rapidly using ultrasonic guidance in severely ill pediatric patients with obstructive uropathy. B-mode ultrasonography has proved to be rapid, accurate and free of radiation hazards, making it applicable to children with little or no sedation. Guided by ultrasound, percutaneous antegrade pyelography should be considered in the few, selected children with obstructive uropathy when the diagnosis is critical for management and difficult with the usual imaging procedures.

Child↗
PubMed1991

The prevalence of microalbuminuria in diabetes: a study from north India.

Geographic/population variation in the prevalence of diabetic nephropathy is well recognised. In a study of 'native' Indians, we screened 102 non-proteinuric diabetes mellitus patients (64 NIDDM, 38 IDDM; mean age and diabetic duration 48.7 and 6.5 years, 21.6 and 6.2 years, respectively) with blood pressure less than or equal to 170/105 and without congestive heart failure, ketonuria or urinary tract infection, for the presence of microalbuminuria (albumin excretion rate greater than 20 micrograms/min). Fifty-six patients (34 NIDDM, 22 IDDM) also underwent detailed fundus examination. Seventeen NIDDM (26.6%) and 3 IDDM (7.9%) patients had microalbuminuria. Glycated hemoglobin was significantly higher in microalbuminurics in the NIDDM group (P less than 0.05). Diabetic retinopathy tended to occur more frequently in microalbuminurics (NIDDM and IDDM).

Albuminuria↗
PubMed1991

Atypical mannolipids characterize Thy-1-negative lymphoma mutants.

Essentially all eukaryotic cells, including murine lymphomas, express surface proteins, such as Thy-1, which are anchored by a phosphoinositol mannolipid. Putative mannolipid anchor precursors can be detected in these cells. Six distinct Thy-1-negative lymphoma mutants lack complete mannolipids, and three mutants synthesize atypical mannolipids. The absence of complete mannolipids can account for the lack of expression of multiple mannolipid-anchored proteins and may also account for the lack of lipid anchoring in the human disease paroxysmal nocturnal hemoglobinuria. Structural information on the mannolipids of wild-type and mutant cells indicates that anchor biosynthesis in these cells may involve both transmembrane flip-flop of intermediates and a deacylation step.

Animals↗
PubMed1991

Hydatid disease.

Explore the source record for details and available documents.

Child↗
PubMed1991

Biting rhythms of malaria vector Anopheles culicifacies in Kheda district, Gujarat.

All night collections on bovine baits were made in 6 villages of Kheda district, Gujarat. During 70 all night bait collections from January to December 1989, a total of 2290 An. culicifacies were collected. An. culicifacies mostly exhibited bimodal rhythms with a seasonal shift in peak biting activities. During the cold season most biting occurred just after dusk and during the warm season late at night. An. culicifacies was more active during moonless hours and its activity showed no correlation with temperature and humidity during most part of the year.

Animals↗
PubMed1991

Isolation and laboratory evaluation of an indigenous strain of Bacillus sphaericus (9001).

An indigenous strain of Bacillus sphaericus H5a (9001), possessing high insecticidal properties, was isolated from diseased larvae of Culex species. This strain in comparison with the known strains of B. sphaericus, i.e., 1593 and 2362, was found to be promising against the fourth instar larvae of Anopheles culicifacies, An. stephensi, An. subpictus, Aedes aegypti and Culex quinquefasciatus. B. sphaericus 9001 is highly stable and virulent through 25 successive transfers and thus can be effectively used as a biocontrol agent against immature stages of mosquitoes.

Animals↗
PubMed1991

Seasonal prevalence of anophelines in Kheda district, Gujarat.

Seasonal changes in the population structure of anophelines were studied in Kheda district, Gujarat. Mosquito collections were made from the villages of Nadiad taluka, representing 3 different physiographic zones. Maximum number of anopheline species (13) were recorded from canal irrigated area followed by 11 species from non-canal irrigated and 8 species from riverine areas. Four anophelines namely An. subpictus, An. culicifacies, An. annularis and An. stephensi were predominant. High densities of An. culicifacies and An. subpictus were recorded in March and August. Results of a four year study (1985 to 1988) on the population of anophelines from 3 different physiographic entities showed marked differences in the seasonal abundance of different species.

Animals↗
PubMed1991

A quantitative survey of anophelines in six villages of Kheda District, Gujarat.

Sampling of anophelines from six villages of Kheda district, Gujarat was done using four different methods viz. indoor resting, outdoor resting, bovine bait trap and immature collections. A total of 113,487 specimens representing 17 species were collected. An. subpictus (66.51 per cent) was most abundant species followed by An. culicifacies (14.12 per cent) and An. tessellatus (5.24 per cent). Bovine bait collections were found most productive yielding maximum species and highest number of anophelines per unit of collection efforts. Indoor resting collections yielded poorest diversity and greater number of specimens per unit of collection effort than outdoor resting collections. Maximum diversity was observed in outdoor collections. Most of the species exhibited unimodal prevalence.

Animals↗
PubMed1990

L-lactate high-efficiency hemodialysis: hemodynamics, blood gas changes, potassium/phosphorus, and symptoms.

Hemodynamic changes were measured during high-efficiency hemodialysis (HEHD) using three dialysis solutions: L-lactate (46 mM), bicarbonate (35 mM + 4 mM acetate), and acetate (39 mM). Cardiac output was determined by changes in thoracic electrical bioimpedance. Although there appeared to be subtle differences in hemodynamic response to L-lactate versus bicarbonate, the blood pressure, cardiac output, and total peripheral resistance were affected less with either of these solutions than with acetate. In particular, neither L-lactate nor bicarbonate HEHD were associated with a change in cardiac output, whereas with acetate HEHD a marked (22%) increase in cardiac output was seen concurrently with a moderate fall in blood pressure and TPR. Both acetate and L-lactate HEHD were associated with hypoxemia, whereas with bicarbonate HEHD the PO2 did not change. With L-lactate HEHD, correction of pH and plasma HCO3 concentrations was delayed but these values were not significantly different from those obtained with bicarbonate HEHD by one hour after dialysis. Potassium removal was comparable with the three dialysis solutions. Phosphorus removal with L-lactate tended to be slightly less than with bicarbonate, but not less than with acetate. Our results suggest that L-lactate (46 mM) dialysis solution may be a suitable alternative to acetate for HEHD, being associated with a hemodynamic profile that is similar to that of bicarbonate and better than that of acetate. Our results further suggest that the hypoxemia associated with the use of acetate dialysis solution is not intrinsic to acetate, but is due either to a low dialysis solution PCO2 level or to accelerated consumption of oxygen during substrate metabolism.

Acetates↗