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Biomedical subjects

D Jung

Publications and source records attributed to D Jung.

At least 163 records · Page 9Linked to original sources
PubMed1981

[Animal experiments with bile peritonitis].

Contrary observations exist in the publications concerning the bile peritonitis. Therefore the effect of sterile bile in the peritoneal cavity was investigated in the white mouse. We had the following results: 1. The L.D. 50 will be obtained only by high bile concentrations. 2. The chemical bile effect is minimal on the visceral and parietal peritoneum in the early and late phase. 3. The bile peritonitis does not get infected in case of the intact gastrointestinal and biliary tract. There does not exist a so-called passing through peritonitis even with big bile quantities. 4. A reduction of the peritoneal adhesions arises by bile influence and by weak adhesion stimuli.

Animals↗
PubMed1981

Gas-chromatographic assay for thiopental in plasma, with use of a nitrogen-specific detector.

An accurate, sensitive, and specific gas-liquid-chromatographic procedure is described for determining concentrations of thiopental in human plasma. After a double extraction of 0.2 or 1.0 mL of plasma containing phenobarbital as an internal standard, thiopental and the internal standard are derivatized in a polar non-aqueous solvent system with iodomethane. The reaction mixture is then evaporated, the residue reconstituted with ethyl acetate, and 20 microL injected into a 3% OV-17 column of a gas chromatograph equipped with a nitrogen-phosphorus detector. Linearity and reproducibility over the concentration range 25 microgram/L to 10 mg/L in plasma are excellent. The sensitivity and wide range of linearity exhibited by this method permit thorough characterization of the disposition of thiopental after the usual induction doses of 3-4 mg/kg of body weight.

Blood Chemical Analysis↗
PubMed1981

The "ultra-free" ultrafiltration technique compared with equilibrium dialysis for determination of unbound thiopental concentrations in serum.

We compare a new ultrafiltration technique, involving a unique Millipore membrane, with the classical method of equilibrium dialysis for determining the fraction of thiopental not bound to serum proteins. This fraction, as determined by equilibrium dialysis at 37 degrees C, ranged between 12 and 16% for total concentrations at 50 microgram/L to 10 mg/L of serum. In contrast, ultrafiltration at 37 degrees C yielded a 49% higher value for unbound thiopental: 26.3 (SD 2.6)%. Determined at room temperature (24 degrees C), there was no statistically significant difference for results by the two methods: 14.2 and 15.9%, respectively. The discrepancy between results at 37 degrees C may partly be explained by serum proteins penetrating the Ultra-Free filter. For the routine clinical measurement of unbound drug concentrations, the ultrafiltration membrane at room temperature appears to be sufficiently accurate and less time-consuming than equilibrium dialysis.

Blood Chemical Analysis↗
PubMed1980

Effect of dose on phenytoin absorption.

To determine the effect of dose on phenytoin bioavailability, a single intravenous 15-mg/kg dose, single oral doses of 400, 800, and 1,600 mg, and 1,600 mg in divided doses (400 mg every 3 hr) were given to six healthy male subjects. Values of Vmax (maximum elimination rate) and Km (serum concentration at which rate of elimination is one half the maximum rate) from the intravenous dose were used to determine the extent of absorption. Although no statistically significant difference in extent of phenytoin absorption was detected, the time to reach maximum phenytoin serum concentrations increased from 8.4 hr for the 400-mg dose and 13.2 hr for the 800-mg dose to 31.5 hr for the 1,600-mg dose. After the 400, 800, and 1,600-mg doses and 1,600-mg divided doses, the serum concentration peaks were 3,9, 5.7, 10.7, and 15.3 mg/l. It is suggested that the prolonged, but complete, absorption of large phenytoin doses is due to slow dissolution and continued absorption from the colon. Due to prolonged absorption of phenytoin, it may be necessary to use larger oral than intravenous loading doses to achieve the same maximum phenytoin serum concentrations.

Administration, Oral↗
PubMed1980

"High-pressure" liquid chromatography of sulfisoxazole and N4-acetylsulfisoxazole in body fluids.

We describe a simple, rapid chromatographic method for separating and quantitatively determining sulfisoxazole and its N4-acetyl metabolite in plasma and urine. A 100-micro L sample of plasma or urine is combined with 200 micro L of a solution containing 12 mg/L of the internal standard, N4-acetylsulfamethoxazole, in absolute methanol and centrifuged to obtain a clear supernatant solution. This solution is then eluted through a 10-micron microparticulate column with a mobile phase of 32/68 (by vol) methanol/sodium acetate buffer (0.01 mol/L, pH 4.7), at a flow rate of 1.2 mL/min. The eluted sompounds are detected by their absorption at 254 nm. We calculated concentration from the peak-height ratios of sulfisoxazole or N4-acetylsulfisoxazole to N4-acetylsulfamethoxazole. The peak-height ratio was linear with concentration in the range 0.05--200 mg/L for both drug and metabolite in plasma and urine. Because this assay can be completed within 30 min of obtaining a blood or urine sample, it should be a valuable tool in clinical drug monitoring and pharmacokinetic studies.

Chromatography, High Pressure Liquid↗
PubMed1979

[Anastomosis prolapse of the gastric mucosa].

X-rays of 91 patients who underwent gastric surgery between 1973 and 1977 were retrospectively evaluated. We found 16 large mucosal prolapses through the gastroduodenal anastomosis and another six with a so-called anastomosis bulge. Of these patients, 77% presented complaints in relation to delayed gastric emptying. When analyzing the prolapse frequency, patient age at the time of surgery, type of surgery, and suture technique, we found that mucosal prolapse occurred mostly in older patients with an extensive gastric resection after oralis-partialis anastomosis and after employing the two-layered suture technique.

Adult↗
PubMed1978

[Haemiton compositum in the ambulatory therapy of hypertension].

Comparative treatments of 14 patients suffering from arterial hypertension of the stages II to IV with haemiton and haemiton compositum (haemiton, triamteren and hydrochlorothiazide) lasting three weeks each showed that under influence of haemiton compositum the systolic blood pressure was lower in which case particularly reactions of orthostasis were practically absent. Measured on the approach of the quotient duration of pulse period to duration of basic vibration T/Tfem to the integrity and to the temporary peak value after Jungmann and coworkers which is parallel to the contractility the regulatorily better behaviour of the circulation under haemiton compositum is significantly expressed. In this case no changes of glucose content in the blood and of the potassium content in the serum appear. The sodium content of the serum slightly decreased in the medication of the combination preparation containing the saluretic. Under haemiton compositum the side effects are more insignificant.

Adult↗
PubMed1978

[Symptoms, signs and therapy of the septate gallbladder (author's transl)].

The septate gallbladder probably represents a congenital anomaly of form, that can be proven by X-ray in 3,8% of hospitalized patients. Only in 25% of these cases it has an own symptomatic significance. Here it does lead though, more or less distinctly, to the typical painful discomfort, comparable to the cholelithiasis, especially augmented by dietary sins, up to the state of colics. The symptoms intensify during the clinical course. Because the gallbladder remains in most cases without the finding of concrements, the misjudgement in these cases often leads to an unnecessary prolongation of the interval between diagnosis and operative treatment.

Adult↗
PubMed1978

[Symptomatic hernia (author's transl)].

A symptomatic hernia (most inguinal or femoral hernia, seldom epigastric, umbilical or post-operative hernia)--appeared a little while ago--originates from a preexisting, so far unknown or long since known illness. All patients with a hernia--especially those over 40 years old--are to be carefully asked for preexisting illnesses. Barium-enema and rectoscopy are not indicated at each inguinal or femoral hernia as a screening-method to exclude a symptomatic hernia; however, both methods must be employed in suspicious cases. 320 Patients with a histologically verified carcinoma of the rectum and colon had no inguinal or femoral hernia. From 387 patients with an inguinal or femoral hernia 318 patients were over 40 years old; at these patients polyps were found in five cases by rectoscopy, but never by barium-enema, and two carcinoma of the colon transverse appeared by barium-enema. A 23-years old patient with a great intraabdominal malignant tumor must be added to the sum total.

Adolescent↗