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Biomedical subjects

D Jourdan

Publications and source records attributed to D Jourdan.

23 records · Page 2Linked to original sources
PubMed1994

[Drugs for relief of pain].

Currently, the pharmacology of analgesics can be sum up to three main compounds: morphine, paracetamol and aspirin. The use of antidepressants and anticonvulsants will also be mentioned. Morphine remains the reference compound among centrally acting analgesics both for acute and chronic pain. Its mechanism of action is relatively well known as well as the role of opiate receptors. Paracetamol is largely used as analgesic for relief of slight to moderate pain. Its mechanism of action still remains unclear. Usually the tolerability of this compound is considered as being excellent. However overdosage can induce severe and possible lethal liver necrosis. Aspirin is also a very old and a largely used compound. Its inhibiting effect on cyclooxygenase acts mainly peripherally but it could also act centrally. According to the current knowledge of its mechanism of action, it seems that the main pharmacological properties as well as adverse events of aspirin are all related to its enzyme inhibiting effect. Slight to moderate pain, related or not to inflammatory disease responds well to aspirin and other NSAIDs.

Acetaminophen↗
PubMed1993

Vocalization elicited by activation of A delta- and C-fibres in the rat.

Complex vocal responses in both the audible and ultrasonic frequency ranges were elicited by a single 2 ms electrical pulse applied to the tail. The first two cries exhibited consistent latencies and durations, were intensity-dependent and were triggered by peripheral fibres with conduction velocities of 7.3 +/- 0.8 and 0.7 +/- 0.1 ms-1, respectively. These behavioural responses are reminiscent of first and second pain triggered by A delta- and C-peripheral fibres in humans. They were followed by irregular audible cries with a fundamental frequency of 1.5 kHz and '22 kHz ultrasonic calls'.

Animals↗
PubMed1989

[Galand disk implant and pupillary block].

We have implanted 530 Galand's disc lens in the last 15 months. Stability and self-centering of implant were good when peroperative vitreous pressure was normal and in any case when wound was closed. Pupillary blocks, specific complications of this lens were rare (less than 1%); they can be prevented occurred by simple and adequate protocols.

Adolescent↗
PubMed1988

[Changes in serum lipids and lipoproteins in 3 cases of heterozygous familial hypercholesterolemia treated by LDL apheresis on dextran sulfate-cellulose columns].

Three patients with heterozygote type IIa hyperlipoproteinemia were treated by specific LDL apheresis with a dextran sulfate-cellulose column every two weeks. Each apheresis resulted in a fall in total cholesterolemia of about 50 p. 100 with a parallel fall in apoprotein B. The average drop of 15 p. 100 in HDL-cholesterol appeared to be due to the hemodilution induced at the end of apheresis. After two months, cholesterol and apoprotein B concentrations before removal were 15 p. 100 lower than baseline values. Treatment was well tolerated. These findings appear encouraging for the treatment of heterozygote forms of familial hyperlipoproteinemia resistant to chemotherapy.

Adult↗