Biomedical subjects

D Janotová

Publications and source records attributed to D Janotová.

3 recordsLinked to original sources

PubMed2005

The effect of gemcitabine in the treatment of rejection in experimental small intestine transplantation.

The aim of our study was to test the immunosuppressive effect of gemcitabine in monotherapy following heterotopic SBT in the rat. The BN and LEW rats were used as donors and recipients, respectively. Recipients were divided into 4 groups--group A without immunosuppression, group B treated with a therapeutic dose of tacrolimus, groups C and D treated with various doses of gemcitabine (100 and 150 microg/kg/day). Immunosuppression was administered once a day for 7 days after SBT, when the animals were sacrificed and a histological examination of grafts was performed. Only in group B no signs of acute rejection were seen. Significant differences (P < 0.01) were noted only between group B versus groups A, C, and D. No significant differences were demonstrated between groups A versus groups C, D and between group C versus group D. Monotherapy by gemcitabine (when administered at given doses) was not shown to be effective in preventing acute rejection in a rat model of heterotopic SBT.

Animals↗

PubMed2005

[An experimental model of the lymphatic vessels transplantation].

The aim of this work is to describe a procedure of primary reconstruction of the lymphatic vessels on a model of heterotopic intestine transplantation in a rat. Both the donor and the recipient part of the procedure are described in a detail, as well as diagnostic methods of postoperative patency of the lympahatic anastomosis. In the end, the authors' own trial group is presented. However, no statistically significant differences were detected in histological findings of the intestinal graft rejection in rats with lymphatic anastomosis, compared with the control group.

Anastomosis, Surgical↗

PubMed1989

[Aggressive behavior in adolescent groups].

Aggressive behaviour of adolescents may be based either on an inborn personality structure, or cultivated by training, i.e. the character of punishment. It is encountered in children with organic disorders of the CNS or psychotic disease. A specific case is aggressive behaviour in communities, being found in particular in communities of boys. The authors describe a typical case of an aggressor and the typical profile of the victim. Psychiatric intervention involves psychotherapeutic treatment and influencing of the social and family which should be focused on possible aggressive behaviour.

Adolescent↗