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Biomedical subjects

D Janić

Publications and source records attributed to D Janić.

11 recordsLinked to original sources
PubMed2002

Stress-induced Cushing's syndrome in fur-chewing chinchillas.

One of the most serious problems in the chinchilla industry is 'fur-chewing', when the chinchilla bites off areas of its own or some other animal's fur. The condition generally develops in both genders at the age of 6-8 months. In chinchilla farms in Croatia an incidence of 15-20% has been observed. A pathomorphological, microbiological and parasitological investigation was conducted on eleven 6- to 11-month-old chinchillas of both sexes with clinical symptoms of 'fur-chewing' and three chinchillas without such signs. Histopathology of the adrenal glands and of the chewed skin revealed changes typical of Cushing's syndrome in 'fur-chewed' chinchillas, such as hyperkeratinisation of the epidermis, epidermal atrophy, pronounced follicular and sebaceous gland atrophy, hyperkeratinisation of the follicles with comedo formations and the presence of calcium salts in subcutis.

Adrenal Glands↗
PubMed1992

[Child trauma in Vojvodina].

Trauma represents for quite a long period a significant problem in child health care in Vojvodina. For better understanding of the trends of trauma in overall registrated child morbidity and mortality includingoutpatient and hospital cases we used the data derived from retrospective study fora period from 1979 to 1988. Analyzing the structure of ten leading groups of illnesses in the outpatient groups of children by the age of 6 years, injuries and intoxications were on the sixth position with the frequency of 2% and for the same period had a progressive increase with the dynamic index of 105.30. The percentage of the injuries and intoxications in the registrated outpatient morbidity of children from 6 to 14 years was 5-5.5% which put them on the fifth position at the list of ten leading groups of illnesses. During the same period of time trauma registered in the hospital morbidity showed decrease with the dynamic index of 86.12 and was on the fourth position with 7-8% of overall morbidity. There are on the average 74 child deaths annually in Vojvodina caused by injuries and intoxications.

Adolescent↗
PubMed1983

[Preleukemia].

Case reports dealing with preleukemic syndromes are rare. During the last years preleukemia has been ill defined. Nowadays, most authors agree that a marrow stem disorder with clinically recognisable haematological abnormalities, which proceed the development of overt leukemia, is to be regarded as preleukemia syndrome. Clinical and haematological features are different in preleukemic syndromes terminating with acute lymphoblastic (ALL) and acute non-lymphoblastic leukemia (ANLL). We describe two cases of preleukemia--the first evolving into ALL and the second into ANLL. Our first patient had developed pancytopenia and hypocellular bone marrow five months before overt ALL. In the moment the diagnosis was made clinical examination revealed enlarged lymph glands, liver and spleen. Laboratory tests showed pancytopenia and bone marrow infiltrated with blasts L1 morphology (F. A. B. classification). Preleukemic phase terminating with ANLL featured pancytopenia and hypercellular bone marrow infiltrated with histiocytes, some showing signs of erythrocyte-, leukocyte- and platelet-ingestion. Diagnosis of acute monoblastic leukemia M5 (F. A. B.) was made three months after the illness onset, according to bone marrow infiltration with monoblasts. Clinical and haematological features helpful in the recognition of preleukemic syndromes are discussed.

Bone Marrow↗
PubMedDate not supplied

[Response to histamine in the skin prick test in children].

Allergen skin reactivity to histamine assessed by Prick testing was studied in 183 children with different allergic symptoms, aged from 4 months to 15 years. No significant difference was noted in male children versus female in different parts of the arm (antecubital fossa of the left arm, wrist of both arms) and in different allergic disorders (respiratory, pollen and skin allergy). The volume of reaction was not significantly changed in repeated applications of histamine. The peak reaction to histamine appeared 5 minutes after the application of histamine in the majority of children; it gradually declined after 10 and 15 minutes.

Adolescent↗