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Biomedical subjects

D J Ward

Publications and source records attributed to D J Ward.

At least 73 records · Page 4Linked to original sources
PubMed1981

Rheumatoid arthritis: returning patients to work.

Fifty-two patients with stable rheumatoid arthritis were followed-up for one year after being referred to the Disablement Resettlement Officer for work counselling. The proportion of patients employed following work counselling initially increased from 35% to 67%, falling to 57% after one year. In addition, 44% of patients "off sick" were re-established at work by job modification. Comparison of patients employed or unemployed one year later indicated that successful employment was related more to social and environmental factors than disability ro financial considerations.

Adolescent↗
PubMed1981

Osmic acid versus yttrium-90 in rheumatoid synovitis of the knee.

The effectiveness of osmic acid and yttrium-90 in the treatment of synovitis of the knee in rheumatoid arthritis is compared in 126 patients followed-up for 3 years. Ninety-one knees were injected with osmic acid and eighty-four knees with yttrium-90. Osmic acid appeared to be more effective than yttrium-90 throughout the period of the follow-up but the difference only reached statistical significance (p less than 0.05) at 3 years. Both therapies were well tolerated by patients and should be considered as an alternative to operative synovectomy.

Aged↗
PubMed1980

A review of early mortality and morbidity in elderly patients following Charnley total hip replacement.

To assess the effects of ageing upon the outcome of total hip replacement, the in-patient records of 100 elderly patients who had undergone Charnley hip replacement procedures within the last decade were reviewed. There were 74 women and 26 men and their mean age was 80 years. Osteoarthritis was the cause of hip disease in 94 patients and rheumatoid arthritis the cause in the remaining six patients. The early mortality and morbidity rates were 4% and 77%, respectively, and the average duration of hospital treatment 42 days. Infection was the commonest post-operative complication followed by mental confusion and adverse drug reactions; multiple complications were a frequent finding. Avoidable complications are indicated and recommendations made regarding the pre-operative, operative and post-operative management of elderly patients.

Aged↗
PubMed1980

The supinator notch sign in rheumatoid arthritis.

Erosion of the ulna, giving a notch-like appearance in the region of the supinator groove, is reported in 18% of 110 unselected outpatients attending a rheumatoid clinic. The characteristic radiological, arthrographic and scintigraphic findings are presented. The mechanism, significance and differential diagnosis is discussed.

Aged↗
PubMed1980

Intra-articular osmic acid in rheumatoid arthritis: five years' experience.

Two hundred and one patients (305 knees) with rheumatoid arthritis received intra-articular osmic acid in one or both knees. Assessment was based on pain relief, warmth, tenderness, size and presence of effusion, degree of synovial thickening and range of pain-free movement. Satisfactory results were obtained in 61% at one year gradually reducing to 22% over a five-year period. If only those knees with none or minimal joint damage were considered, then a satisfactory result was obtained in a higher percentage, 74% at one year and 38% at five years.

Adolescent↗
PubMed1979

Control of excitation in the fluorescence microscope.

In fluorescence microscopy image brightness and contrast and the rate of fading depend upon the intensity of illumination of the specimen. An iris diaphragm or neutral density filters may be used to reduce fluorescence excitation. Also the excitation bandwidth may be varied by using a broad band exciter filter with a set of interchangeable yellow glass filters at the lamphouse.

Immunologic Techniques↗
PubMed1978

Estimation of IgM rheumatoid factors by fluorimetry.

Sheep red cells coated with rabbit IgG antibody may be used to detect IgM rheumatoid factors either by agglutination or microscopically by the fluorescence of antihuman IgM antibody conjugate bound to rheumatoid factors on the cell surface. By substituting for red cells the plastic surface of a filter disc coated with rabbit IgG it was possible to elute the bound conjugate and measure the fluorescence in a fluorimeter. The results of both the sheep cell agglutination test and the fluorescence test agreed quite well for the majority of sera; both tests seemed to reflect IgM rheumatoid factor concentrations in these sera. The difficulties encountered in attempting to define and measure accurately rheumatoid factor concentrations in a serum are emphasised.

Antigen-Antibody Complex↗
PubMed1978

Measurement of total haemolytic complement activity in body fluids.

The measurement of total haemolytic complement is of diagnostic value in the rheumatic diseases. A method which is easier to perform than that of Kabat and Mayer (Experimental Immunochemistry, 2nd ed., Thomas, Springfield, Ill.) is described. A unit based on the mean value of the complement activities of normal sera is proposed to replace CH50 units. Other steps by which standardisation of the assay may be improved are suggested.

Body Fluids↗
PubMed1976

Polyarthritis in adults with hypogammaglobulinaemia and its rapid response to immunoglobulin treatment.

Five patients with primary hypogammaglobulinaemia developed a severe polyarthritis that had some features in common with rheumatoid arthritis. Their joint disease could be distinguished from rheumatoid arthritis, however, by the dramatic improvement after gammaglobulin treatment. The arthritis of hypogammaglobulinaemia can, therefore, be included among the few potentially curable polyarthritides.

Adolescent↗
PubMed1975

An evaluation of two new screening tests for rheumatoid factors.

Two further commercial screening tests for rheumatoid factors have been evaluated using both the sheep cell agglutination (SCAT) test and the Rheumaton slide test used routinely in this laboratory. In the group of sera tested, the Rheumaton test detected all sera with elevated SCAT titres; the Searle RA Latex test failed to detect a few of these sera. The Rheumaton test gave many misleading positive reactions with sera having insignificant SCAT titres. Far fewer misleading positive results were obtained with the Searle test. The Rythrotex test gave results similar to Rheumaton but was very difficult to use.

Agglutination Tests↗