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Biomedical subjects

D J Wagenfeld

Publications and source records attributed to D J Wagenfeld.

11 recordsLinked to original sources
PubMed1987

The negative effects of mucolytics in otitis media with effusion.

Much controversy still exists in the treatment of otitis media with effusion. A double-blind randomised prospective trial during which bromhexine hydrochloride was compared with a placebo is reported. Information from 60 patients was analysed and the results reveal interesting findings on the effects of bromhexine on middle-ear clearance. The data clearly reveal that bromhexine retards resolution of the effusion. Further discussion of the literature gives insight into the controversy surrounding the treatment of middle-ear effusion. Steroids are proposed for further research and clinical trials.

Acoustic Impedance Tests↗
PubMed1987

Cochlear implants.

Explore the source record for details and available documents.

Child, Preschool↗
PubMed1983

Treatment of otitis externa with miconazole nitrate. A comparative study involving 85 cases.

The hazards of neomycin in local preparations have recently been re-emphasized. Eighty-five patients with otitis externa were treated with one of two preparations between August 1980 and April 1982 -- 54 were treated with a cream containing miconazole nitrate and hydrocortisone (Daktacort; Janssen) and 31 with a preparation containing neomycin (Kenacomb; Squibb); Sixty eight per cent of the patients were cured within 1 week with both preparations. Most treatment failures were due to a resistant Pseudomonas aeruginosa. The miconazole cream proved as effective as the preparation containing neomycin in the first-line treatment of otitis externa. A gentamicin-containing steroid ointment was effective against the Pseudomonas infection.

Clinical Trials as Topic↗
PubMed1981

[Tympanoplasty in septic cases. A new technic].

The very incidence of postoperative sepsis in tympanoplasty operations on ears with infected cholesteatoma prompted the development of a new technique to improve the control of local infection. An irrigation tube is placed into the mastoid antrum at the time of operation, through which the ear is irrigated in the postoperative period with an antibiotic solution. In 25 tympanomastoidectomy operations, only 6 patients developed postoperative sepsis, 5 of which were due to faulty administration of the antibiotic. In 13 tympanoplasty operations, 6 patients had an unsuccessful outcome. Four of these were due to poor patient selection. Systemic antibiotics are given immediately preoperatively, and continued in the postoperative period until the course has been completed.

Anti-Bacterial Agents↗
PubMed1981

Second primary respiratory tract malignant neoplasms in supraglottic carcinoma.

In this study, a second respiratory tract malignant neoplasm developed in 20 of 163 cases of supraglottic carcinoma either at the time of diagnosis or after diagnosis. Using an actuarial method of calculation, 19% of the survivors will experience a second respiratory tract malignant neoplasm within five years after the diagnosis of supraglottic carcinoma. This is three times the incidence in patients who survive glottic carcinoma and 14 times the incidence in the normal population. A third of this group of patients with supraglottic carcinoma are alive and well at five years, a third died of supraglottic cancer, and a third died of intercurrent disease. The death rate from intercurrent disease is twice that seen in the general population, and this difference is due almost entirely to second respiratory tract tumors. Even if the cure rate of patients with primary supraglottic carcinoma was 100%, only half of these patients would actually be alive at five years, owing to deaths from intercurrent disease. More emphasis needs to be placed on the reduction of the mortality from second respiratory tract tumors with the use of screening or preventive methods.

Glottis↗
PubMed1981

Gastric pull-up vs deltopectoral flap for reconstruction of the cervical esophagus.

Reconstruction of the cervical esophagus and pharynx after a total laryngopharyngectomy for patients with advanced hypopharyngeal cancer still remains a problem for surgeons. The results of two procedures, the tubed deltopectoral flap reconstruction and the gastric pull-up operation with pharyngogastric anastomosis, which are used in fulfilling postoperative deglutition requirements, were compared. There were nine patients in the gastric pull-up group and eight patients in the deltopectoral flap group. The groups were reasonably comparable with regard to age, sex, preoperative radiotherapy, and stage of tumor. Three of the patients in the gastric pull-up group were operated on for palliation alone. Average operation-to-swallow time was 12 days for the gastric pull-up groups and 90 days for the deltopectoral flap group. Reconstruction of the gullet with the stomach pull-up operations seems to be superior to the tubed deltopectoral flap. This is especially true if the operation is palliative because the patient is unlikely to survive more than one year after surgery.

Adult↗
PubMed1980

Second primary respiratory tract malignancies in glottic carcinoma.

Of 740 cases of glottic cancer, a second respiratory tract tumor developed in 48. Only 14 cases would have been expected in a sample of the same age and sex distribution drawn from the general population of Ontario. Of 25 patients with second tumors in the lung, 23 are dead. Of these 23, 17 had been cured of Stage T1 glottic cancer. An actuarial method for calculating the risk of developing a second respiratory tract tumor amongst the survivors of glottic cancer is described. Of the survivors, 12% will have a second respiratory tract tumor within ten years following initial diagnosis of glottic cancer. Of patients with Stage T1 glottic cancer, 7% will die of a second respiratory tract tumor within ten years. This rate is slightly more than that for those who die of laryngeal cancer in this stage grouping. Late recurrences and/or second primary tumors in the larynx following radiotherapy are rare. Methods for reducing the risk of death from a second respiratory tract tumor are discussed.

Canada↗
PubMed1980

Primary carcinoma involving the temporal bone: analysis of twenty-five cases.

Twenty-five patients with primary carcinoma involving the temporal bone were reviewed. Pain and discharge were the most common complaints. A history of previous otitis media was found in 64% of the patients. On clinical and radiological assessment, 18 cases were deemed surgically resectable and 7 unresectable. Analysis of treatment revealed 3 groups of patients: an unresectable group of 7 patients treated by primary radical radiation therapy in which there were no long-term survivors; another group received primary radiotherapy with surgery reserved for residual or recurrent disease--4 of this group of 12 survived 4 years or longer; and the remaining group had primary surgery with radical postoperative radiation therapy--4 of this group of 6 patients survived 4 years or longer despite incomplete surgical removal of tumor in all except 1 patient. The results and possible reasons for failure are discussed.

Adult↗