Biomedical subjects

D J Reen

Publications and source records attributed to D J Reen.

65 records · Page 4Linked to original sources

PubMed1981

Atopy and cystic fibrosis. A study of CF sibling pairs and their families.

We have investigated the prevalence of atopy within families of cystic fibrosis (CF) patients and compared its frequence in CF patients, their parents and their non-CF siblings. By studying families with two CF patients it was also possible to evaluate the factors influencing the development of atopy in one CF patient relative to the other patient within the same family. A significant correlation with age (P less than 0.001) for skin test positivity to common allergens within CF sibling pairs was observed. In 14/18 families studied, only the older CF patient was atopic. The presence of atopy in CF patients was independent of the atopic status of their parents.

Adolescent↗

PubMed1981

Immune status of the neonate maintained on total parenteral nutrition.

Immunological studies were carried out on 7 neonates maintained on total parenteral nutrition for periods ranging from 14 to 31 days after surgery for correction of gastrointestinal anomalies. IgM and IgA levels were high in all patients but IgG levels were low, compared with normal values. Total leucocyte counts, absolute lymphocyte counts, and T- and B-lymphocytes in all patients were similar to those of healthy controls. Neonates maintained on adequate total parenteral nutrition showed no evidence of impairment of immune function.

B-Lymphocytes↗

PubMed1980

Lymphocyte transformation after surgery in the neonate.

Nine neonates born with congenital malformations were investigated for lymphocyte response to phytohemagglutinin (PHA). No significant change was found in the transformation response of lymphocytes to PHA after surgery, which is in contrast to studies reported in adults and older children.

Anesthesia, General↗

PubMed1980

HLA antigen frequencies in an Irish population.

Two-hundred-and-fifty-three unrelated Irish adults were typed for 24 alleles at the HLA--A and B loci. A high frequency of HLA--B8 (34.8%) was observed compared with results published for other populations. Results of other gene frequencies, haplotype frequencies and linkage disequilibrium values were similar to those of Caucasian population studies. Close similarity of HLA polymorphism distribution was seen in relation to another relatively homogeneous Celtic population from the islands of the Outer Hebrides, off the coast of Scotland.

Alleles↗

PubMed1980

HlA antigens and steroid responsive nephrotic syndrome of childhood.

Fifty-four unrelated children with steroid responsive nephrotic syndrome of childhood were studied for 24 alleles at the HLA--A and B loci. A significantly increased incidence of HLA--B8 (Pc less than 0.01) was observed compared to controls. No association between response to cyclophosphamide therapy and HLA antigens was seen.

Adrenal Cortex Hormones↗

PubMed1979

Lymphocyte response after surgery in the neonate.

Fourteen neonates born with congenital malformations were investigated for lymphocyte function before and after surgery. Total leucocyte and absolute lymphocyte counts were unaltered after surgery. The mean percentage of T-lymphocytes observed either pre- or postoperatively was considerably lower than that reported in older children and adults. While there was an increase in the percentage of B-lymphocytes after operation in the infants, the absolute number of B-cells remained unchanges. The preoperative transformation response of lymphocytes to PHA (mean 12.9 +/- 5.4 X 10(3) counts/min) was little different from the postoperative values (mean 12.4 +/- 4.4 X 10(3) counts/min). These results suggest that the neonate is immunologically different from older children and adults in its response to anaesthesia and surgery.

Anesthesia, Inhalation↗

PubMed1979

Immunological studies in neonates with spina bifida.

Fifteen neonates with spina bifida were investigated prior to surgery for T and B lymphocytes subpopulations and mitogen responsiveness to PHA. Results were compared to similar studies in 30 normal healthy neonates. The mean percentage of T-lymphocyes in spina bifida patients was 44.6% compared to 48.9% in normal neonates. A normal dose response to PHA was obtained in all patients. These results suggest no impairment of lymphocyte function in neonates born with spina bifida.

B-Lymphocytes↗

PubMed1977