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Biomedical subjects

D J Moore

Publications and source records attributed to D J Moore.

At least 181 records · Page 10Linked to original sources
PubMed1985

Are strokes predictable with noninvasive methods: a five-year follow-up of 303 unoperated patients.

To determine the correlation between the degree of internal carotid arterial stenosis demonstrated by noninvasive tests and the risk of subsequent stroke, 303 consecutive patients who underwent cerebrovascular evaluation with the Hokanson ultrasonic arteriograph were reviewed retrospectively. Ninety percent of the patients were followed up for 5 years or until the time of death. Stroke occurred in 41 (13.5%) patients. There was a significant correlation (p = 0.04) between the incidence of stroke and severity of disease: greater than or equal to 50% stenosis (19%), 0% to 49% stenosis (11%), and no stenosis (10%). Stroke as a presenting complaint carried the highest risk of subsequent neurologic defect (24%), but the risk in patients without symptoms was appreciable (15%). Life-table analysis indicated that the incidence of stroke was low (less than 3%) in the asymptomatic and nonhemispheric group during the first 2 years after evaluation when the degree of stenosis was less than 50%. Thereafter, the stroke rate increased. Half the deaths were due to myocardial infarction; the risk of death from cardiac causes was doubled in patients with greater than 50% stenosis. It is concluded that the demonstration of hemodynamically significant stenosis does select a group of patients at increased risk for subsequent stroke and myocardial infarction, but lesser degrees of stenosis do not exclude future neurologic events.

Actuarial Analysis↗
PubMed1985

Topical chemotherapy of intradermal Walker 256 carcinosarcoma with diaziquone and doxorubicin in the rat.

A model for metastatic skin cancer using intradermal injection of Walker 256 carcinosarcoma has been developed in the rat. Using this model, antitumor activity of topically applied doxorubicin and diaziquone in Vanicream, Plastibase, and dimethyl sulfoxide (DMSO) as vehicles was compared with intraperitoneal injection of the drugs at the same doses beginning 4 days after injection of tumor cells. Doxorubicin applied topically at 0.5 mg/day for 4 days in Vanicream or Plastibase exhibited no antitumor activity, while i.p. administered doxorubicin at 0.5 mg/day for 4 days inhibited tumor growth at day 20 by 66%. Diaziquone applied topically at 0.1 mg/day for 4 days in Vanicream, Plastibase, or DMSO inhibited tumor growth at day 20 by 66, 86, and 43%, respectively, and cured animals of the skin tumor at a dose of 0.5 mg/day. Diaziquone administered i.p. at 0.5 mg/day for 4 days was lethal to rats, and at 0.1 mg/day it produced 93% inhibition of tumor growth at day 20. Diaziquone applied topically at 0.1 mg/day for 4 days in Plastibase cured rats of advanced tumor when treatment was begun 12 days after injection of tumor cells. The area under the plasma radioactivity time curve over 5 h for a single 0.64-mg dose of topically applied [ring-14C]diaziquone in DMSO was 0.01% that of the same dose of [ring-14C]diaziquone administered i.p. in non-tumored rats. The decrease in WBC count following topical application of diaziquone at a dose of 0.1 mg/day for 4 days, compared to the same dose of diaziquone administered i.p., was 62% in Vanicream, 81% in Plastibase and 33% in DMSO. Topical diaziquone was non-toxic to normal skin in the rat and in the domestic pig. It is concluded that topical application of diaziquone offers a therapeutic advantage over systemic treatment for metastatic cancer of the skin.

Absorption↗
PubMed1984

Paradoxical interventions in behavioral medicine.

This article discusses the current and potential use of paradoxical interventions in behavioral medicine. Paradoxical interventions are considered to be of two types: intra-individual and interpersonal. Treatment indications differ for the two types of interventions. Intraindividual paradoxical interventions have been successful in the treatment of insomnia, psychogenic urinary retention and constipation. Interpersonal paradoxical interventions have been subjected to less empirical research, but have been useful in the treatment of anorexia nervosa and in family based interventions where medical patients maladaptively cope with their rehabilitation. Paradoxical procedures are also used in the treatment of sexual dysfunction and may be of value in pain management. Further possible applications as well as limitations of paradoxical interventions in behavioral medicine are discussed.

Anorexia Nervosa↗
PubMed1984

Compulsive polydipsia presenting as diabetes insipidus: a behavioral approach.

Although compulsive polydipsia or self-induced water intoxication is known to occur with a relatively high frequency in psychiatric patients, much of the literature has focused on medication treatment and interactions; little has been written describing alternative methods of intervention. This paper describes an inpatient treatment using both EMG biofeedback and response prevention. The relationship between compulsive appetitive behaviors and more classic presentations is discussed. Because the patient was treated on the endocrine service, the importance of adequately training non-psychiatric staff is emphasized. It is suggested that this may be a model for the behavioral management of psychiatric problems on medical/surgical wards.

Adult↗
PubMed1984

Ultrasound diagnosis of gastro-oesophageal reflux.

A method of diagnosing gastro-oesophageal reflux using ultrasound is described. This method was compared with barium swallow examination in 20 patients and found to be as accurate in infants and young children.

Adolescent↗
PubMed1984

Influence of the contralateral carotid artery on neurologic complications following carotid endarterectomy.

To examine the effect of contralateral carotid artery stenosis on postoperative events, a retrospective review was made of 451 patients undergoing 510 carotid endarterectomies during a 6-year period. Three degrees of contralateral carotid stenosis were identified radiologically: 0% to 49%, 50% to 99%, and totally occluded. Each group was further separated into two categories according to preoperative symptoms. "Low risk" included asymptomatic lesions, transient ischemic attacks, and nonhemispheric symptoms; "high risk" described poststroke patients and urgent operations. The results show the incidence of stroke or death was not increased in patients with severely stenosed or occluded contralateral vessels in either low- or high-risk patients (p = 0.741 and p = 0.561, respectively). Patients in the high-risk category, however, had a significantly higher risk of postoperative complications than patients in the low-risk category (p less than 0.001). The study reaffirms that preoperative indications have a major influence on surgical outcome and suggests that the status of the contralateral artery has little bearing on postoperative events.

Adult↗
PubMed1983

A twenty-year evaluation of subperiosteal implants.

All Vitallium subperiosteal mandibular implants placed at UMKC from 1955 to 1975 were reevaluated from four objective and subjective standpoints. It can be concluded that (1) the UMKC implants surpass the 5- and 10-year longevity standards of the Harvard Conference on Dental Implants; (2) periodic recall is an important part of an implant program; (3) acute inflammation is prevalent among implant patients; (4) surgical removal of part of an implant framework can be preventive treatment and prolong the life of the implant; (5) all but one of the implants reviewed were successful to a degree; (6) unilateral anesthesia or paresthesia can be expected in approximately 50% of patients; (7) anesthesia was not a deterrent to success in this study; (8) satisfaction with the implants was absolute; and (9) if removal of an implant was necessary, patients requested replacement if possible.

Chromium Alloys↗
PubMed1983

Canine parvovirus immunoprophylaxis: a review.

The presently available data on canine parvovirus is reviewed with particular emphasis on the degree of immunity provided by the various types of vaccines commercially available, the interference of active immunisation by maternally-derived antibody, and the recommendations as to age of vaccination.

Animals↗