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Biomedical subjects

D J Mehan

Publications and source records attributed to D J Mehan.

32 records · Page 2Linked to original sources

Meiotic figures in the testicular biopsy of subfertile males.

The phases and sequence of meiotic division are herein reviewed and illustrated as they occur in the human testis. Normally all phases of meiosis can be identified, and arrest at a phase is indicative of faulty spermatogenesis. The correlation of these arrest patterns with the clinical course and response to clinical therapy is now in progress. These meiotic studies can be undertaken in any laboratory with cytogenetic capabilities, and this study is intended to serve as a base line illustration of the normal.

Biopsy↗

Results of ligation of internal spermatic vein in the treatment of infertility in azoospermic patients.

Ten azoospermic men treated by ligation of the internal spermatic vein are reported. Treatment of two of the ten resulted in pregnancies. The advisability of thorough evaluation of the azoospermic patient is well demonstrated by the finding of one patient with Klinefelter's syndrome. In our judgement, based on this small series, azoospermia should not be considered a contraindication to surgery. Complete evaluation of the azoospermia is essential. Indeed, the varicoceles seen in patients 9 and 10 were an incidental finding and in all likelihood played no role in the azoospermia.

Humans↗

Polyorchidism.

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Adult↗

A study of meiotic preparation of human spermatocytes and their relationship to infertility.

Although our experience is based on a small series of 50 cases we believe that several points can be made. Meiotic preparations can be performed in any competent cytogenetic laboratory. These preparations appear to yield more specific information as to the site of arrest and may be more reliable than the static testicular biopsy to appraise the true status of spermatogenesis. With these facts in mind a more accurate prognosis and therapeutic regimen can be realized.

Cytodiagnosis↗

Urethral duplication, with associated agenesis of left kidney and right ureteral ectopia.

We report an unusual case of an accessory or duplicated urethra. This case is unique because of its association with multiple urologic anomalies which made management and diagnosis of this condition unusual. The unusual combination of right ectopic ureter and left renal and ureteral agenesis in association with the accessory urethra is presented, along with the diagnostic and surgical management particular to this case.

Abnormalities, Multiple↗