More on contamination of solutions.
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Drug Contamination↗
Biomedical subjects
D J McIntyre
Publications and source records attributed to D J McIntyre.
Instrumentation for intraocular lens implantation.
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Cornea↗
The fish hook needle.
The bicurved fish hook needle allows placement of consistently short bites to close cataract, keratoplasty or traumatic corneal wounds with minimal tissue compression and astigmatism. The technique of handling is different than that for traditional single-radius needles, however it is easily learned. This bicurved needle should find wide application in other microsurgical procedures, such as vascular anastomosis, tuboplasty and vasovasostomy.
Humans↗
Comparative endothelial biomicroscopy.
Calibrating comparative endothelial biomicroscopy with a corneal endothelial microscope (Heyer-Schulte Medical Optics), we have obtained clinically useful estimates of endothelial cell density. This simple and inexpensive technique allows rapid examination and evaluation of a large number of endothelial cells across various corneal diameters. It is, however, a clinical rather than investigative procedure and is not intended to replace the quantitative features of endothelial specular photomicrography for scientific studies.
Calibration↗
The McCannel suture: a bimanual technique.
The bimanual technique utilizing the iris manipulator and a full air bubble allows excellent control of anterior chamber depth and IOL position. It also minimizes the risk of trauma to the underlying lens, posterior capsule or vitreous during placement of iris sutures; and its use may prevent the tragedy of severe endothelial damage during insertion of the McCannel suture.
Humans↗
Irrigating instruments for intraocular lens implantation.
A series of small instruments to assist with insertion of intraocular lenses and placement of lens fixation sutures has been described. Added to the main function of each, is the capability for infusion of fluid or injection of air and medication.
Anterior Chamber↗
Save the endothelium.
The health of the corneal endothelium is a critical factor in the final outcome of intraocular surgery . With the advent of intraocular lens implantation, the hazard of inadvertent endothelial trauma is greatly increased. A rigorous technique has been presented which will minimize the risk of such trauma in extracapsular cataract surgery with implantation of Binkhorst type intraocular lenses.
Cornea↗
New surgical instrument carrying case.
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Equipment and Supplies↗
The stimulation of fluorescein in external ophthalmic photography.
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Eye Diseases↗
Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours.
The sensitivity of blood oxygenation level dependent (BOLD) contrast techniques to changes to tumour deoxyhaemoglobin concentration is of relevance to many strategies in cancer treatments. In the context of tumour studies, which frequently involve the use of agents to modify blood flow, there are underlying physiological changes different to those of BOLD in the brain. Hence we use the term, flow and oxygenation dependent (FLOOD) contrast, to emphasize this difference and the importance of flow effects. We have measured the R(2)* changes in a prolactinoma tumour model for a variety of vasoactive challenges [carbogen, 100% oxygen and 100% nitrogen as different breathing gases, and administration of tumour blood flow modifiers such as calcitonin gene related peptide (CGRP), hydralazine and nicotinamide]. In addition we have measured other relevant physiological parameters, such as bioenergetic status from (31)P MRS, and blood pH and glucose, that may change during a vasoactive challenge. Here we discuss how they relate to our understanding of FLOOD contrast in tumours. We frequently observe R(2)* changes that match the expected action of the vascular stimulus: R(2)* decreases with agents expected to improve tumour oxygenation and blood flow, and increases with agents designed to increase tumour hypoxia. Unlike most normal tissues, tumours have a chaotic and poorly regulated blood supply, and a mix of glycolytic and oxidative metabolism; thus the response to a vasoactive challenge is not predictable. Changes in blood volume can counteract the effect of blood oxygenation changes, and changes in blood pH and glucose levels can alter oxygen extraction. This can lead to R(2)* changes that are smaller or the reverse of those expected. To properly interpret FLOOD contrast changes these effects must be accounted for.
Animals↗
The selling of a hospital. Why increasing numbers of biomedical communicators will be working to promote hospital services with media presentations.
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Advertising↗
The accreditation question--a call for accountability.
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Accreditation↗
Irrigating lacrimal probe.
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Catheterization↗