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Biomedical subjects

D J Martin

Publications and source records attributed to D J Martin.

185 records · Page 11Linked to original sources

Inappropriate lubricant use with condoms by homosexual men.

Use of condoms has been advocated as an important method of reducing the risk of human immunodeficiency virus (HIV) transmission among high-risk groups such as homosexual and bisexual men, prostitutes, intravenous drug users, adolescents, and hemophiliacs. Despite risk-reduction education campaigns directed to gay men since the early 1980s, evidence shows continued deficits in condom-use skills and knowledge among gay men. Because most failures in the use of condoms are attributed to errors in use, increasing knowledge and skills in condom use is important in preventing HIV infection. Two groups of homosexual and bisexual men were sampled, those entering a risk-reduction education program and participants in a Gay Pride event. They were surveyed on their current sex practices and their efforts to reduce their risk of HIV infection. They were asked about their numbers of sex partners, specific sexual behaviors, use of condoms, types of condoms used, and lubricants used for genital-anal sex. The characteristics of those surveyed were similar to those of respondents in other studies of risk reduction among gay men. The use of an oil-based lubricant with condoms has been shown to weaken latex and to increase the likelihood of condom breakage, which use of water-based lubricants does not. Among respondents who reported having genital-anal sex, 60 percent reported use of an oil-based lubricant with a condom at least once during the year before the survey. Gay men in sexually exclusive relationships engaged in less consistent use of condoms for receptive genital-anal sex than did single gay men. The duration of their relationship with a partner was unrelated to the consistency of risk reducing behaviors practiced by men in sexually exclusive relationships. Gay Pride participants engaged in sexual behavior that was relatively more risky for HIV transmission than did the other group. Gay Pride participants used condoms less consistently for genital-anal sex than did the risk-reduction program entrants.The findings indicate the need for better risk reduction education efforts directed to gay men. Continued improvement in these efforts will require assessing the effectiveness and consistency of risk reduction efforts, determining the potential for gay men to relapse into more risky behavior, and identifying gaps in the knowledge of risk-reduction efforts among gay and bisexual men. Risk reduction programs need to emphasize motivational factors, provide basic information on how one determines the content of lubricants, explain why water-based lubricants only should be used, and teach how to use condoms properly. Active outreach is needed to gay and bisexual men who are unlikely to voluntarily enroll in risk-reduction programs.

Adult↗

A study of the deficiencies in the condom-use skills of gay men.

The use of condoms has been advocated as an important method of reducing the risk of AIDS for such people as gay men, prostitutes, IV drug users, adolescents, hemophiliacs, and others who may become infected with the human immunodeficiency virus (HIV) that causes AIDS. Although AIDS risk-reduction programs have provided information on condoms, none has assessed baseline or followup skills in their use. Because most condom failures have been attributed to errors in use, promoters of condom use should determine whether they are used correctly among those persons targeted for education. A total of 219 gay men entering an AIDS risk-reduction program were asked to demonstrate the use of condoms on a model. All errors made during the demonstration were corrected, and participants were trained during the exercise in the proper use of condoms. More than 80 percent required correction in such things as opening the package, determining the outside of the condom, unrolling the condom to the base of the penis, and expressing air from the space at the tip of the penis. Although proper use of condoms may seem obvious, this small study demonstrates that it must be taught. Since instructions found in condom packaging frequently are not easily understood by potential users, explicit instructions for condom use are needed.

Acquired Immunodeficiency Syndrome↗

Effect of acute hypoxia on lung fluid balance in the prerecruited dog lung.

Lung lymph flow and protein transport were measured in eight anaesthetized dogs while acute hypoxic exposure (FIO2 = 0.10) was performed on prerecruited lung (achieved by an increased left atrial pressure). It was found that the lung lymph flow increase observed during hypoxia (from 71.8 +/- 47.5 to 100.8 +/- 78.4 microliters X min-1; p less than 0.05) was associated to an unchanged lymph/plasma protein concentration ratio (from 0.60 +/- 0.9 to 0.60 +/- 0.11). During recovery from hypoxia, lymph flow remained at a higher level than before hypoxia (respectively 87.8 +/- 49.5 and 71.8 +/- 47.5 microliters X min-1). These results suggest that the mild hypoxia-induced oedema is rather a high permeability oedema than an haemodynamic oedema. A graphic representation of protein clearance changes versus lymph flow changes was used in order to discriminate between high permeability and haemodynamic oedemas at their early stage.

Animals↗

Effect of acute hypoxia on lung transvascular filtration in anaesthetized dogs.

The pulmonary transvascular filtration changes were investigated in nine anaesthetized open-chest dogs during acute hypoxic exposure. The tracheobronchial pulmonary lymph flow, the lymph and plasma protein concentration, the pulmonary vascular pressures and the cardiac output were measured during three consecutive steady states of about 2 h each: 1) base-line, 2) hypoxia (FIO2 = 0.10), 3) recovery from hypoxia. It was found that pulmonary arterial pressure and lung lymph flow increased in all animals during hypoxia, respectively from (average +/- SD) 19.4 +/- 4.5 to 27.1 +/- 5.6 Torr, and from 27.2 +/- 10.2 to 59.8 +/- 23.8 microliters . min-1; lymph to plasma protein concentration ratio remained unchanged. During recovery, lung lymph flow remained elevated in some animals, while it returned to its initial value in the others. Control experiments with normoxic hyperventilation in five dogs showed no increase in lymph flow. The extravascular water/blood free dry lung ratio was moderately increased in animals that had been made hypoxic (4.64 +/- 0.67) compared to a control group (3.46 +/- 0.36). These results suggest that acute hypoxic exposure causes an increased pulmonary transvascular filtration in anaesthetized dogs.

Acute Disease↗