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Biomedical subjects

D J Lea

Publications and source records attributed to D J Lea.

At least 37 records · Page 2Linked to original sources
PubMed1975

An evaluation of two new screening tests for rheumatoid factors.

Two further commercial screening tests for rheumatoid factors have been evaluated using both the sheep cell agglutination (SCAT) test and the Rheumaton slide test used routinely in this laboratory. In the group of sera tested, the Rheumaton test detected all sera with elevated SCAT titres; the Searle RA Latex test failed to detect a few of these sera. The Rheumaton test gave many misleading positive reactions with sera having insignificant SCAT titres. Far fewer misleading positive results were obtained with the Searle test. The Rythrotex test gave results similar to Rheumaton but was very difficult to use.

Agglutination Tests↗
PubMedDate not supplied

Synovial fluid total hemolytic complement activity in rheumatic diseases - a reappraisal.

The varied and contradictory claims made of the clinical value of measuring total hemolytic complement activity in rheumatic diseases prompted a reappraisal of its role, and a review of the literature, taking into account the anomalies of assay and the semi-quantitative nature of the procedure. We found that measurements of synovial fluid (SF) total hemolytic complement activity were of limited value in determining the diagnosis or prognosis of joint diseases. Also there was no significant relationship between SF total hemolytic complement activity and either clinical activity or other laboratory findings. We believe that measurements of SF complement activity will prove of little use as a guide to the effectiveness of drug therapy.

Arthritis↗