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Biomedical subjects

D J Lane

Publications and source records attributed to D J Lane.

82 records · Page 5Linked to original sources
PubMed1971

Mechanism of hyperventilation in acute cerebrovascular accidents.

Lumbar cerebrospinal fluid and arterial blood acid-base state were assessed in 19 patients within 24 hours of an acute cerebrovascular accident. Those with haemorrhage into the C.S.F. showed a lower C.S.F. pH and higher C.S.F. lactate than those without haemorrhage but the Pco(2), was similar in the two groups, suggesting that this greater C.S.F. acidity was not responsible for a greater degree of hyperventilation. In those without haemorrhage an inverse relation was found between C.S.F. pH and arterial Pco(2), suggesting that a non-chemical ventilatory drive-for example, due to central neurological damage-was responsible for the acid-base changes observed.

Acidosis↗
PubMed1969

Changes in blood gas tensions and functional residual capacity chronic asthmatics treated with disodium cromoglycate.

Twenty chronic asthmatic subjects were treated with disodium cromoglycate in open trial. Although in the group as a whole spirometric findings improved, some patients showed a significant increase in arterial oxygen tension or a significant fall in functional residual capacity without any appreciable changes in spirometry. These changes may partly explain the clinical efficacy of this drug.

Adult↗
PubMed1968

Relation between airways obstruction and CO2 tension in chronic obstructive airways disease.

The relationship between the F.E.V.(1) as an index of airways obstruction and Pco(2) as an index of hypoventilation was investigated in 13 patients with chronic obstructive airways disease. Patients who had a normal Pco(2) despite severe airways obstruction retained relatively normal sensitivity to CO(2) as assessed by their "inspiratory mechanical work rate" response to CO(2). Others showed a raised Pco(2) in the presence of lesser degrees of airways obstruction and had reduced sensitivity to CO(2).

Arteries↗