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Biomedical subjects

D J Ellis

Publications and source records attributed to D J Ellis.

At least 55 records · Page 3Linked to original sources
PubMed1986

Bioequivalence of norethindrone and ethinyl estradiol for two different weight tablets with the same hormonal content.

Two tablets of differing weights, 100 mg (A) and 50 mg (B), of an oral contraceptive drug (OC) were compared with each other and to a solution (C) of the same components. The composition of the OC consisted of 1 mg of norethindrone (NET) and 0.035 mg of ethinyl estradiol (EE2). Both tablets were shown to differ from the solution, which was more rapidly absorbed, but were not significantly different from each other. Formulation means for NET and EE2, for each of the two products, were similar. Application of an interval test for the ratio of computed parameters demonstrated equivalence of the two formulations with respect to 0-24 hr area under the curve (AUC24) and total area under the curve (AUC+o+) for both NET and EE2 and with respect to concentration maximum (Cmax) for EE2. The data support the hypothesis for bioequivalence of the two formulations with respect to total absorption.

Absorption↗
PubMed1986

Preputial calculus: a case report.

A preputial calculus developed postoperatively in a child with epispadias. Analysis of the pathophysiological development of this lesion and a review of the literature are presented. The inert subpreputial space may become calculogenic in the presence of phimosis and urinary stasis.

Calculi↗
PubMed1986

Patterns of infant feeding in the first six months.

A quasi-experimental six months longitudinal study of women planning to breastfeed was carried out in Vancouver, B.C., Canada. The purpose was to increase breastfeeding duration through the provision of nursing support, and information about breastfeeding. This paper reports on the patterns of infant feeding by 131 mothers for six months postpartum. Included are data on initiation of breastfeeding, feeding intervals, supplementation, initiating semi-solids and duration of breastfeeding. Unsupplemented breastfeeding declined from 90.8% at the time of discharge from hospital to 65% at one month, 45% at three months and 3.9% at six months. For some infants, semi-solids were introduced at one month and by three months 11.4% were being fed semi-solids. The implications for health care professionals caring for breastfeeding women are outlined.

Adult↗
PubMed1985

Naproxen in prophylaxis of migraine.

Naproxen sodium is an inhibitor of platelet aggregation and prostaglandin synthesis and is also a potent anti-inflammatory agent. Because of these properties, it was evaluated in prophylaxis of migraine by a double-blind, placebo-controlled crossover study in 34 patients. Drug "preference" and therapeutic effect were rated by both patient and investigator. Overall, both preferred drug over placebo. An index of migraine activity was calculated from a daily record kept by the patient; it demonstrated a significant reduction in headache severity, duration, disability, and medication needed. Adverse effects were minimal and similar in drug and placebo. Naproxen is a promising agent in the prophylaxis of migraine.

Adult↗
PubMed1985

Successful migraine prophylaxis with naproxen sodium.

Naproxen sodium, a potent inhibitor of prostaglandin biosynthesis and platelet aggregation, was studied for efficacy in migraine prophylaxis in a randomized, double-blind, placebo-controlled, crossover trial. On naproxen treatment, 52% of the patients had no severe headaches, whereas 19% had no severe headaches during placebo. Naproxen sodium was much better than placebo when patients' diaries were reviewed for severity of attacks, nausea, vomiting, activity reduction, duration of headache, and decreased use of therapeutic medication. The degree of platelet inhibition did not correlate with efficacy in preventing headache. Naproxen sodium can be recommended as a drug of first choice for migraine prevention.

Adult↗
PubMed1984

Clinicopathological staging of gastric cancer.

13 175 patients with gastric carcinomas have been staged with reference to the TNM staging system. This has confirmed the poor overall prognosis (5.5 per cent and 3.8 per cent age-adjusted survival rates at 5 and 10 years respectively). However, it has demonstrated the significant survival associated with the treatment of Stage I disease (70.0 per cent at 5 years and 63.2 per cent at 10 years). This study demonstrates that 72.9 per cent of cases are unresected and that interpretation of resectability rates must be related to the population base of the study.

Humans↗
PubMed1983

Do nurses help or hinder mothers who breastfeed?

A 5-week programme of breastfeeding inservice education, included classes on a repeated series of three topics, a film, provision of reading material, tests and the availability of a nurse-clinician for consultation and assistance. The study was carried out in a 50-bed maternity unit. Participation was voluntary. Of the 112 registered nurses and 42 practical nurses, between one-third and one-half participated in one or more of the various aspects. Follow-up tests revealed considerable disagreement among the staff on knowledge and nursing interventions related to breastfeeding.

Attitude of Health Personnel↗
PubMed1983

Secondary school students' attitudes and beliefs about breastfeeding.

The incidence and prevalence of breastfeeding has increased in the United States and Canada in the past decade, but in spite of its known benefits it is often abandoned before infants are two months of age. Society lacks the attitudes and knowledge necessary for breastfeeding success. A survey of the knowledge, beliefs and attitudes of 409 secondary school students in British Columbia, Canada, revealed misconceptions about the nature of breastfeeding. A high percentage felt it was unacceptable in social situations. The findings point to a need for the integration of information about breastfeeding into school health programs, biology, home economics/nutrition and family life/sexuality courses. Increased knowledge and discussion to foster positive attitudes could increase breastfeeding duration among parents in the future.

Adolescent↗
PubMed1982

Reflectance spectrophotometric quantification of skin colour changes induced by topical corticosteroid preparations.

Reflectance spectrophotometry was used to observe the degree of vasoconstriction induced by topically applied corticosteroids. The average blanching effectiveness of the corticosteroid preparations as determined by this technique was the same as that found by other workers using subjective assessments. Reflectance spectrophotometry can be utilized to quantify the degree of vasoconstriction produced by local corticosteroids applied to the skin and is particularly suitable for measuring the response of individual subjects.

Administration, Topical↗