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Biomedical subjects

D J Dire

Publications and source records attributed to D J Dire.

25 records · Page 2Linked to original sources
PubMedDate not supplied

The use of sublingual nifedipine in a patient with a clonidine overdose.

We report the case of a 46-year-old woman who took approximately 8 mg of clonidine in a suicidal gesture. She arrived in the emergency department 45 min after the overdose with severe hypertension and an altered mental status. Nitroprusside, which is the drug of choice for treating this "paradoxical hypertension," was not readily available. The patient was treated with a total of 20 mg of nifedipine sublingually. This resulted in a rapid decline in her blood pressure and an improvement in her mental status. We review the toxicology of clonidine overdose and discuss its treatment.

Administration, Sublingual↗
PubMedDate not supplied

Movement disorders as a manifestation of nonketotic hyperglycemia.

Movement disorders are well-known presenting signs of metabolic disorders. Focal motor abnormalities may be the chief initial presentation of diabetes mellitus in the nonketotic hyperglycemic state in 6% of patients. Nonketotic hyperglycemia (NKH), in particular, may manifest any of a wide variety of movement disorders. These have been described as focal seizures, epilepsia partialis continua, myoclonus, and opsoclonia. There are descriptions of movement disorders in hyperglycemia that are similar to the coarse flapping tremor of asterixis, the posturing of paroxysmal kinetogenic choreoathetosis, and of "fencing (stance) seizures." Disorders of facial motor function including aphasia, facial muscle twitching and jerking, and disorders of muscular tone have been described. These may include hemiparesis and hemiplegias as well as increased tone, in some cases mimicking the nuchal rigidity of meningitis. The movement disorders in NKH may mimic cerebral vascular accidents, meningitis, or psychiatric disorders, as well as various types of seizures. Clinicians may be able to avoid expensive and time-consuming diagnostic evaluations to rule out NKH in patients with movement disorders. We present two patients with focal motor abnormalities associated with nonketonic hyperglycemia and review the pertinent literature.

Adult↗
PubMedDate not supplied

Neurocysticercosis presenting to the emergency department as a pure motor hemiparesis.

We report the case of a 23-year-old male who presented to the emergency department (ED) with an isolated right-sided pure motor hemiparesis (PMH). An unenhanced computed tomography (CT scan) revealed a hypodensity in the area of the left parasagittal motor strip. The patient then experienced a Jacksonian type of seizure involving his right leg and was treated with intravenous phenytoin and dexamethasone. A second CT scan performed with contrast was thought to be consistent with a cerebral abscess with surrounding white matter edema. Surgical findings were consistent with neurocysticercosis. The patient was treated with praziquantel with nearly full recovery. Worldwide, cysticercosis is the most common CNS parasite. Because of immigration from endemic areas, cysticercosis has become more common in the United States. Patients with neurocysticercosis may arrive in the ED with a wide variety of unusual presentations. In this case, the PMH syndrome was caused by a solitary lesion in the motor strip. This report describes a case of PMH due to neurocysticercosis secondary to local mass affect alone. The literature of neurocysticercosis and PMH is reviewed and the pathogenesis, clinical presentation, and therapy are discussed.

Adult↗
PubMedDate not supplied

A prospective survey of procedures performed by emergency medicine residents during a 36-month residency.

Future specialty training requirements for emergency medicine may include adequately documented records of procedures and resuscitations performed. A computer database was developed to track these data and to report the experience of one graduating class of nine emergency medicine residents. This study was a prospective survey conducted at a community hospital with a fully accredited (PGY 1-3) emergency medicine residency program. This study showed that data on resident procedures can be adequately documented using a computer database to determine whether requirements for emergency medicine resident training are met. The problems of resident data entry compliance and determining procedural competence are discussed briefly.

Confounding Factors, Epidemiologic↗
PubMedDate not supplied

Baclofen and ethanol ingestion: a case report.

The number of reported cases of skeletal muscle relaxant ingestion has been increasing in the United States, although fatalities are rare. A 30-year-old women ingested 300 mg of baclofen and ethanol. She was able to ambulate into the Emergency Department (ED) 50 min later, but within 30 min post-arrival had a Glasgow Coma Score of 3. She was treated with supportive care including mechanical ventilation for 36 h. Her neurologic status returned to her previous state. Coma may occur rapidly after baclofen overdose, and the respiratory depression may be exacerbated by the co-ingestion of ethanol. Primary importance in the treatment of such ingestions should be placed on maintenance of an airway and respiratory support.

Adult↗
PubMedDate not supplied

A prospective evaluation of risk factors for infections from dog-bite wounds.

OBJECTIVE: To define risk factors for infections from dog- bite wounds and to model the probability of wound infection in patients presenting without infection who are treated as outpatients. METHODS: A prospective survey of 769 consecutive dog-bite victims presenting over a two-year period to a community hospital emergency department (ED) with an emergency medicine residency program. A standardized wound-cleaning protocol was used, which included debridement and wound closure when indicated. Wounds were examined for infection at follow-up. Variables analyzed included demographic data (patient age, gender, race); wound information (wound age, type, number, location, depth); and treatment (prior to hospital, ED debridement, suturing, tetanus or rabies shots, antibiotics). RESULTS: There were 734 patients with complete records. These patients had a mean age of 13.4 +/- 13.2 years (range, 4 months to 71 years). Infection was evident in 2.5% of the wounds upon presentation. There were 704 patients (765 wounds) managed as outpatients and without wound infection upon presentation. Wounds were distributed as follows: 26.7% head/neck, 20.4% hand, 15.7% arm, 10.1% trunk, 9.5% thigh, 15.9% leg, and 1.7% foot. There were 32.9% puncture, 39.9% full-thickness, and 60.1% partial-thickness wounds. Wound infections were diagnosed in 2.1% Of these wounds at follow-up. Wounds requiring surgical debridement had a sevenfold higher infection rate (p = 0.01). Patients more than 50 years of age had a sixfold higher infection rate than younger patients (p = 0.05). Stepwise logistic regression found the following variables to be the best predictors for wound infection: full-thickness [p = 0.006, odds ratio (OR) = 6.23], female gender (p = 0.048, OR = 2.88), and wound debridement (p = 0.024, OR = 5.01). Combinations of these three variables predict infection rates from 0.35% to 23.9%. CONCLUSION: A low wound infection rate was seen in this cohort of dog-bite victims who were treated on an outpatient basis. Wound depth, patient gender, and wound debridement were the clinical variables that best predicted the likelihood of developing infection. Future interventional studies should concentrate on wounds with high probabilities of infection.

Adolescent↗