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Biomedical subjects

D J Dawson

Publications and source records attributed to D J Dawson.

At least 55 records · Page 3Linked to original sources
PubMed1985

Technetium 99m-labelled-sucralphate isotope scanning in the detection of peptic ulceration.

An isotope scan using sucralphate labelled with technetium-99m has been compared with barium meal in the detection of peptic ulceration in 18 patients with endoscopically proven upper gastrointestinal lesions and eight controls. Gastric (75%) and duodenal (67%) ulcers were detected with identical frequency by isotope scan and barium meal but both were inferior to endoscopy. Structural, non-ulcerated lesions, were not identified by isotope scanning. The scan has potential value in duodenal ulcer disease, the serial assessment of ulcer healing and in paediatric gastroenterology.

Barium Sulfate↗
PubMed1984

Coeliac disease presenting with intestinal pseudo-obstruction.

A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a case of coeliac disease with secondary pseudo-obstruction, rather than primary intestinal pseudo-obstruction with secondary bacterial overgrowth, is discussed.

Adult↗
PubMed1983

Mycobacterium asiaticum as a potential pulmonary pathogen for humans. A clinical and bacteriologic review of five cases.

Mycobacterium asiaticum was isolated from pulmonary material from 5 persons residing in Queensland, Australia. All patients had repeated positive specimens, but the organism was considered responsible for pulmonary mycobacteriosis in only 2 of them. This is the first report of disease caused by M. asiaticum. Clinical, bacteriologic, and epidemiologic details are presented.

Aged↗
PubMed1982

Mycobacterial cross-contamination of bronchoscopy specimens.

Bronchoscopy specimens from 3 patients investigated during 1 wk at a large teaching hospital were culture positive for the same serovar of Mycobacterium intracellulare. Review of laboratory records and patient data suggested that only the first patient examined was a genuine excretor of mycobacteria; the isolates from the other 2 patients were false positives caused by inadequate disinfection of part of the collection apparatus between use. The investigations confirm the suitability of glutaraldehyde as a rapid, highly effective antimycobacterial disinfectant and illustrate the value of serotyping when dealing with mycobacterial isolates of questionable significance.

Aged↗
PubMed1981

Mycobacterium haemophilum causing lymphadenitis in an otherwise healthy child.

Suppurating submandibular lymphadenitis in an otherwise healthy infant was caused by Mycobacterium haemophilum, A fastidious organism which requires media supplemented with ferric ammonium citrate or haemoglobin for its growth. It is recommended that material from superficial lesions and lymph nodes collected for mycobacteriological investigations be cultured on media known to support growth of M. haemophilum.

Humans↗
PubMed1981

Differential identification of mycobacteria in smears of sputum.

As a test of their ability to differentiate mycobacteria in Ziehl-Neelsen stained smears of sputum, 4 readers examined an assortment of 200 smears, of which half were known to contain Mycobacterium tuberculosis and half were known to contain atypical mycobacteria. In 2 separate trials, readers made a prediction of either 'typical' or 'atypical' for each smear. Reader consistency between trials ranged from 69.5% to 86.5%, indicating that readers were basing their predictions on definite criteria. Overall accuracy ranged from 62.5% to 80%, with experienced readers being the most accurate. Reliability of readers' predictions was influenced by smear positivity, but certain smears exhibited uncharacteristic features which led to incorrect predictions. When considered along with other available data, smear-based presumptive diagnosis can assist the clinician in his management of the patient with suspected tuberculosis in the period before culture results are known.

Bacteriological Techniques↗
PubMed1981

Misleading results from bone marrows cultured for mycobacteria.

Re-evaluation of a previous study dealing with atypical mycobacteria grown from specimens of bone marrow provided strong evidence that the isolates were of no clinical significance. Bone marrow culture should not be undertaken as a diagnostic test for pulmonary atypical mycobacteriosis.

Bone Marrow↗
PubMed1981

Ontario accelerator dose intercomparison study.

An ionometric dose intercomparison has been carried out on eight accelertors, with maximum photon energies from 6 to 32 meV, at five radiotherapy centres in Ontario. The ratio of the dose based on the clinically-employed rad/monitor unit to the dose measured by the committee representative had a mean value of 0.994, with a range of 7.3% and a coefficient of variation of 2.5%. The ratio of the dose measured by the institution's physicist to the dose measured by the committee representative had a mean value of 1.000 with a range of 6.9% and a coefficient of variation of 2.3%. Eight recommendations regarding dose calibration procedures are presented.

Humans↗
PubMed1980

Mycobacteria of the intracellulare-scrofulaceum group in soils from the Adelaide area.

Soil samples from the Adelaide area--where organisms belonging to the Mycobacterium intracellulare-scrofulaceum (MIS) group are rarely encountered in sputum of persons under investigation of pulmonary mycobacterial disease--were examined for the MIS group. Thirty-one per cent were positive for MIS organisms and 17% were positive for MIS serotypes known to be disease-associated. Comparison with an earlier study of soils from the Brisbane area--where this group of organisms is frequently isolated from sputum of persons under investigation for pulmonary mycobacterial disease--suggests that the disease-associated MIS serotypes are significantly more common in the environment of the Brisbane area. This implies a positive correlation, and consolidates existing evidence that the environment is the reservoir of, and a source of infection with, organisms of the MIS group.

Australia↗
PubMed1979

Pulmonary disease caused by Mycobacterium xenopi in an Australian man.

A 63-year-old man with a history of increasing cough with sputum, weight loss, and lethargy was found to have pulmonary disease caused by Mycobacterium xenopi, a species rarely seen in Australia. Chemotherapy was successful. Apart from war service in Papua New Guinea, the patient had not travelled outside Australia.

Australia↗
PubMed1979

Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.

Prostaglandin synthetase activity in rectal biopsy specimens from patients with ulcerative colitis has been shown to fall on treatment with sulphasalazine, local steroids, and codeine phosphate. In vitro studies have shown that sulphasalazine is an inhibitor of prostaglandin synthetase, although less potent than indomethacin, whereas prednisolone and codeine phosphate were inactive. It is suggested that the therapeutic action of sulphasalazine may be related in part to its action in inhibiting prostaglandin biosynthesis.

Codeine↗