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Biomedical subjects

D J David

Publications and source records attributed to D J David.

At least 109 records · Page 6Linked to original sources
PubMed1983

Chemotherapy of squamous cell cancer of the head and neck.

Forty patients with advanced squamous cell cancer of the head and neck were treated with methotrexate, cisplatin, and bleomycin. Major regression of disease occurred in 69%; 30% of patients achieved complete remission. Fifteen patients received chemotherapy as the initial treatment, followed by either radiotherapy or surgery or both. Subsequent therapy was not prejudiced by this approach. The results demonstrate the marked sensitivity of these tumors to these three agents, and the need for further assessment of their use in optimal patient care.

Adolescent↗
PubMed1983

Three-dimensional reconstruction of craniofacial deformity using computed tomography.

The computed tomographic studies obtained routinely in the examination of patients with congenital or acquired defects of the skull and facial bones can be utilized as a substrate to provide an accurate three-dimensional representation of osseous abnormalities. The total dose of x-irradiation is reduced as other means of radiological examination are eliminated. Osseous structures are faithfully reproduced. Complete inspection of the reproduced structure can be made from any viewpoint, including internal inspection.

Abnormalities, Multiple↗
PubMed1982

Nasendoscopy: significant refinements of a direct-viewing technique of the velopharyngeal sphincter.

The need for a three-dimensional record of velopharyngeal sphincter function in patients with craniofacial anomalies and speech problems is discussed. A refined split-screen video technique using color nasendoscope image, lateral video-fluoroscopy, and synchronous speech recording with the patient awake and in supine position is described. A special signal processor is used to position the color nasendoscopy image. The examination is recorded on 1-in. videotape. The technique allows three-dimensional appraisal of sphincter function with direct viewing and enables assessment of a range of abnormalities, assessment of the effectiveness of pharyngoplasties, and prediction of speech deformities and their management following midface craniofacial surgery.

Endoscopes↗
PubMed1981

Severe cranio-facial deformities and their management.

Historical attitudes to cranio-facial deformities are discussed. A simple nosology of cranio-facial deformities is given, the main groups being craniosynostosis syndromes, facial clefts, tumours, trauma, facial microsomias, and midface hypoplasias. Each group is briefly discussed, with emphasis on the craniosynostosis syndromes and facial clefts. Cases from these two groups are illustrated before and after surgery, showing the dramatic improvement offered by cranio-facial techniques. The basic principles of cranio-facial surgery are briefly discussed, and the complications discussed. The South Australian Cranio-Facial Unit experience with complications is discussed, especially blindness and persistent C S F leaks. The necessity for only a few cranio-facial units each with a high workload is reiterated, and new directions for cranio-facial surgery discussed, including the use of microvascular techniques and early surgery to minimise later deformity, particularly in cases with plagiocephaly.

Craniofacial Dysostosis↗
PubMed1979

The acute toxicity of ethanol: dosage and kinetic nomograms.

We are concerned with the frequency of potentially lethal ethanol intoxications (about 1 pint of hard liquor) in teenagers. We present 2 illustrative cases, discuss the acute toxicity of ethanol, and present 2 simple calculating charts for dosage and kinetics. The widespread use and economic impact of ethanol have kept this potent sedative-hypnotic free of the same federal regulations that control the availability of other drugs with a similar potency and margin of safety.

Acetaldehyde↗
PubMed1979

Microvascular surgery in maxillo-facial reconstruction.

The recent advances in microvascular surgery have been applied to maxillo-facial reconstruction in the area of the lower jaw and soft tissue of the face. Five cases are presented, demonstrating some of the techniques and results in patients suffering from congenital, post-traumatic and post-cancer resection deformities.

Adult↗
PubMed1978

A de-epithelialized free groin flap for facial contour restoration.

The transfer of de-epithelialized free groin flaps to restore facial contour after tumour resection and in hemifacial microsomia is described. The flap can be transferred in one stage and remodelled at a later minor operation. This provides an acceptable alternative to the other more difficult and often less successful methods of restoring soft tissue deficiencies of the face.

Adolescent↗
PubMed1977

Craniofacial surgery: the team approach.

Craniofacial surgery offers a new hope to some grossly deformed people. This complex surgery, which is based on a multidisciplinary team approach, needs to be carefully rationalized and regionalized to facilitate investigation, to improve planning, to reduce the number of complications, and to conserve financial resources. To date the Cranio-Facial Clinic at the Adelaide Children's Hospital and the Royal Adelaide Hospital has reviewed 37 cases and operated upon 13 of these. This work is presented together with a review of the team approach.

Australia↗
PubMed1977

Psychosocial aspects of head and neck cancer surgery.

Thirty-six patients who underwent major surgical excision and reconstruction for head and neck cancer were subjected to a psychosocial assessment in hospital and, later, in their home environments. The information gained from the survey is discussed, with particular reference to those factors which can be used by the head and neck surgical team to improve the quality of the patients' existence.

Adaptation, Psychological↗
PubMed1977

Use of an innervated deltopectoral flap for intraoral reconstruction.

The technique for the transfer of sensitive skin into the mouth for intraoral reconstruction is described. This procedure may be performed at one or two operative stages. Supraclavicular nerves supply sensation to the tip of the standard deltopectoral flap--which may be swung up with the nerves left in continuity, or the nerves may be divided and anastomosed to an appropriate sensory nerve in the mouth.

Carcinoma, Squamous Cell↗