Liquid chromatography detector based on single and twin electrode thin-layer electrochemistry: application to the determination of catecholamines in blood plasma.
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Catecholamines↗
Biomedical subjects
D J Curran
Publications and source records attributed to D J Curran.
Determination of catecholamines by thin-layer linear sweep voltammetry.
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Catecholamines↗
Temporal lobe dysfunction. A case report.
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Adult↗
Treatment of phenothiazine induced bulbar persistent dyskinesia with deanol acetamidobenzoate.
The late manifestation of neuroleptic-induced dyskinesia (persistent dyskinesia) is an irreversible complication of long-term treatment that is poorly understood and difficult to treat. Recently, a theory of dopamine receptor hypersensitivity in the dopaminergic-cholinergic system has suggested an explanation of choreiform movements and, thus, an implication for the management of persistent dyskinesia. The case presented is that of bulbar persistent dyskinesia in a patient who had been prescribed a phenothiazine derivative for eleven years; his symptoms improved with the use of deanol, which probably converts to acetylcholine after crossing the blood brain barrier. This improvement suggests that deanol may shift the neuroleptic-induced dopaminergic-cholinergic system unbalance toward equilibrium by matching predominant dopaminergic effect or by enhancing deficient cholinergic action in the dopaminergic-cholinergic system. This isolated finding needs to be confirmed by more research in neuropharmacology.
Acetamides↗