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Biomedical subjects

D J Bennett

Publications and source records attributed to D J Bennett.

At least 73 records · Page 4Linked to original sources
PubMed1976

The influence of surgery on survival of patients with angina.

Myocardial revascularization surgery has proved most effective in relieving angina pectoris. Its influence on the survival of patients with coronary atherosclerosis, however, remains a contentious subject and one which may not be finally settled for years. The follow-up results of the first 196 patients to undergo direct coronary artery surgery at the Prince Henry Hospital support those who claim increased longevity as one of its benefits.

Adult↗
PubMed1975

Experience with renal vein renin ratios in the identification of a pressor kidney.

The positive, preoperative recognition of a pressor kidney has many important ramifications, the most important being the ability to predict a reduction in blood pressure following surgical reconstruction or nephrectomy. One hundred forty hypertensive patients were selected for study for renal artery stenosis by measuring the differential plasma renin activity by either radioimmunoassay or bioassay. Bilateral renal vein renin determinations and renal arteriography were made consecutively in supine position and without stimulation of renin secretion. Unilateral or bilateral renal artery stenosis was found in 55 patients (39%). Twenty-eight of the 55 patients (51%) were treated surgically. Eighteen patients (64%) were cured of hypertension and seven (25%) were improved. All but one of the surgically treated patients had renal vein renin ratios of greater than 1.3 on the affected side over the unaffected or less-affected side. Increasing the ratio to greater than 1.5 or greater than 2.0 as a criterion for selection of patients for operation would not have decreased the failure rate. If used as the only criterion, increasing the ratios would have resulted in nonsurgical treatment of up to 50% of the patients cured or improved by surgery. Stimulation of renin secretion, although not used in this study, has been shown by others to more accurately identify a pressor kidney by increasing differential renal vein renin ratios. Although a combination of renin activity with renal plasma flow may lead to more accurate diagnosis, a careful clinical evaluation has not yet been replaced as the best method of selection of the patients for operation.

Adolescent↗
PubMed1967

The purification and properties of histidinol dehydrogenase from Neurospora crassa.

1. A procedure is described for the purification of l-histidinol dehydrogenase (l-histidinol-NAD oxidoreductase, EC 1.1.1.23) from Neurospora crassa. 2. The enzyme, as purified, has a sedimentation coefficient, S(20), of 7.1s and a molecular weight of 81 000. Considerable variation is possible in the state of polymerization of the enzyme, giving rise to observed molecular weights from 40 000 to 240 000. 3. Several kinetic parameters of the enzyme have been determined. The enzyme is maximally active at pH9.8; the K(m) (NAD) is 13.0x10(-5)m and K(m) (histidinol) is 8.2x10(-6)m. The enzyme is highly specific, does not oxidize a range of amino alcohols and other aliphatic alcohols nor reduce NADP and has no demonstrable affinity for histidine. The turnover number is 49 moles of NAD reduced/min./mole of enzyme (mol.wt. 40 000).

Alcohol Oxidoreductases↗