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Biomedical subjects

D J Back

Publications and source records attributed to D J Back.

243 records · Page 14Linked to original sources
PubMed1972

The removal of 14 C-edrophonium from the circulation.

The clearance of (14)C-edrophonium from plasma was studied in the rat. Distribution studies showed that 5 min after intravenous injection of the drug, more than half the dose was present in the liver and the kidneys. The concentration in these organs was approximately 20 times the level in other tissues. The plasma concentration of (14)C-edrophonium was invariably expressed as the sum of two exponential terms, suggesting that the drug may return to the circulation from other tissues as the plasma level falls.

Animals↗
PubMed1972

Excretion of 14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus.

1. The metabolism and biliary excretion of (14)C-edrophonium chloride was studied in Wistar rat.2. Approximately 5% of the dose was recovered from bile in 6 hours. Most of the radioactivity was eliminated as (14)C-edrophonium glucuronide. Small amounts of the unchanged drug were also detected in bile, particularly during the first hour after administration of the drug.3. The concentration of (14)C-edrophonium glucuronide in bile was approximately 15-20 times its concentration in plasma.4. In contrast, the concentration of unchanged (14)C-edrophonium was similar in bile and plasma.5. Evidence is presented that unchanged (14)C-edrophonium is transferred from plasma to bile via the peribiliary vascular plexus.

Animals↗