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Biomedical subjects

D Isaacs

Publications and source records attributed to D Isaacs.

At least 163 records · Page 9Linked to original sources
PubMed1986

Childhood gastroenteritis: a population study.

A prospective study of gastroenteritis based on a population was carried out for 12 months on over 7000 children in general practice. The incidence of gastroenteritis was highest in the first year (127.7 children affected per 1000) and second year (90.8) of life, and gastroenteritis was rare after six years of age. Children from urban areas had gastroenteritis more commonly than children from semirural areas. A potential pathogen was isolated from half of the specimens: 78% were viruses, and rotavirus was identified most often.

Adolescent↗
PubMed1986

Racial differences in red cell indices.

A high prevalence of iron deficiency was found in apparently healthy Asian immigrant children in Harrow. After excluding children with overtly abnormal red cell indices, Asian and European children had identical haemoglobin values, but Asian children had much lower mean cell volume and mean corpuscular haemoglobin values and higher red blood cell values.

Asia↗
PubMed1985

Chronic granulomatous disease mimicking Crohn's disease.

A 34-month-old boy with intermittent diarrhoea and abdominal distension from 2 months of age, a chronic microabscess of the cheek, gastric antral narrowing, and perianal abscesses containing granulomata was found at colonscopy to have extensive, noncaseating, submucosal ileal and colonic granulomata. He was initially thought to have Crohn's disease, but then developed a cervical abscess, and a diagnosis of chronic granulomatous disease was established. This is an important, although rare, differential diagnosis of chronic inflammatory bowel disease in childhood.

Abscess↗
PubMed1985

Reference ranges for IgG subclasses in preschool children.

A normal range for IgG1, IgG2, and IgG3 subclasses has been established for children aged 6 months to 5 years using commercially available monoclonal antisera. Of particular interest were the very low concentrations of IgG2 in some healthy children, a finding which casts doubt on the importance of IgG2 deficiency reported in some patients with otherwise unexplained infections. It was not possible to construct a normal range for IgG4 values probably because these segregate into two populations in normal subjects.

Aging↗
PubMed1985

Cryptosporidiosis in immunocompetent children.

Cryptosporidial oocysts were identified by modified Ziehl-Neelsen stain in the stools of seven (3.2%) of 213 children with acute or chronic diarrhoea and one (0.9%) of 112 controls. All children with cryptosporidia were immunocompetent. Four of the index cases had a short illness (3-14 days) with watery diarrhoea, vomiting (2), and abdominal pain (2). Two index cases had chronic diarrhoea for over four months and failure to thrive. Both had a small intestinal enteropathy; one had cryptosporidial oocysts in stool specimens two months apart and the other had cryptosporidial schizonts attached to the jejunal mucosa. One index case had a colitis of indeterminate cause. Four of the index cases had recently travelled abroad. There had been an outbreak of gastroenteritis in the family of one of the index cases, and three affected sisters and an asymptomatic brother had oocysts in their stools. Cryptosporidial infestation seems to be associated with acute gastroenteritis and sometimes with chronic diarrhoea and small bowel damage in immunocompetent children.

Animals↗
PubMed1984

Psittacosis.

Explore the source record for details and available documents.

Adult↗
PubMed1984

Serum immunoglobulin concentrations in febrile convulsions.

The mean, age adjusted, serum IgA values of 47 children with febrile convulsions were almost identical to those of controls. Five children had serum IgA values less than 0.1 g/l by nephelometry, suggesting that in some cases at least there may be an association between a low serum IgA concentration and febrile convulsions.

Child↗
PubMed1984

Immunoglobulin levels and function in pre-school children with recurrent respiratory infections.

Thirty pre-school children with recurrent respiratory infections had a higher age adjusted mean serum IgG level than their siblings or a reference group. One index child had persistently low serum IgA, but mean serum IgA and IgM levels for the index children were normal. All of the 23 index children and 17 siblings studied had a four-fold or greater rise in virus neutralizing antibody titre. There was no correlation between serum immunoglobulin levels and frequency of infections. There was, however, a significant inverse correlation between salivary IgA levels when healthy and the number of infections experienced by each child in the study year. Salivary IgA levels rose considerably during acute infections.

Child↗
PubMed1983

Antigens in whooping cough vaccine and antibody levels induced by vaccination of children.

The content of 3 antigens--filamentous haemagglutinin, lymphocytosis-promoting factor, and serotype-specific agglutinogens (fimbriae)--was determined in the current UK whole-cell whooping cough vaccine. Antibodies to these antigens and to outer membrane proteins and lipopolysaccharide of Bordetella pertussis were measured in the serum of unvaccinated children and children who had received 1, 2, or 3 doses of the vaccine. Children who had received one dose of vaccine had varied low antibody titres. Children who had received two or three doses had significantly higher antibody titres to all the antigens tested, as did some unvaccinated children with no history of whooping cough. This study shows that filamentous haemagglutinin, lymphocytosis promoting factor, and outer membrane proteins are immunogenic constituents of the whole-cell vaccine. Their inclusion in a subcellular vaccine would not involve novel antigens.

Antibodies, Bacterial↗
PubMed1983

Diagnosis of human coronavirus infections in children using enzyme-linked immunosorbent assay.

An enzyme-linked immunosorbent assay (ELISA) was developed for diagnosing human coronavirus (HCV) infections in children. One hundred and seventy seven nose swabs, throat swabs, and nasopharyngeal aspirates were collected from 30 children suffering from acute respiratory infections. These samples were tested for HCV antigens by ELISA and 28.2% of the samples were shown to be HCV positive. These results indicate that our ELISA should prove useful in the diagnosis of HCV infections in children. Further studies are in progress to extend the ELISA to detect HCVs in experimentally and naturally acquired infections in adults.

Antigens, Viral↗