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Biomedical subjects

D Ikkos

Publications and source records attributed to D Ikkos.

At least 19 recordsLinked to original sources
PubMed1996

Paratesticular tumours in a patient with Nelson's syndrome.

An extremely rare case of a 39-year-old man with Nelson's syndrome and paratesticular tumours is presented. The patient had undergone bilateral adrenalectomy at the age 23 years for Cushing's syndrome. Later he developed skin and mucosal hyperpigmentation. Nelson's syndrome was diagnosed, and he underwent transfrontal hypophysectomy. At age 29, the presence of paratesticular tumours was noted which were excised together with the left testis. The preoperative levels of testosterone, produced by the paratesticular tumours, were extremely high; they fell after surgery.

Adrenal Hyperplasia, Congenital↗
PubMed1991

Separation of pseudohypoparathyroidism into types I and II using only basal nephrogenous cAMP determinations.

The separation of pseudohypoparathyroidism (PHP) into Type I (non responders, usually with signs of Allright's hereditary osteodystrophy--AHO--and resistance to other hormones secretion) and Type II (responders) is classically done with the parathyroid hormone (PTH) infusion test using as criterion of cellular response total urinary cAMP determinations. But since total urinary cAMP is not an accurate index of intracellular cAMP production from the renal tubular cells--as is nephrogenous cAMP (NcAMP)--it was considered worthwhile to examine the diagnostic value of NcAMP in this case. A total of 12 PHP patients were studied along with 19 controls of corresponding age and sex. All 31 persons underwent--inter alia--to a 2 hrs I.V. PTH infusion test with 500 I.U. of human 1-34 PTH. Using as criterion total urinary cAMP, the PHP patients were separated into Type I (7 patients, of whom 5 with AHO) and Type II (5 patients). The same results were obtained when the NcAMP stimulation values were used instead, although in PHP Type II patients the mean increase of NcAMP at the end of PTH infusion was 2 fold than the corresponding increase of total urinary cAMP. But the most impressing finding was that the separation of PHP patients to the Types I or II was possible by using the basal NcAMP values only (NcAMP basal values ranged from 0.35 to 0.56 nmols/100 ml GFR in Type I and from 0.93 to 1.75 in Type II PHP). These results render possible the use of NcAMP basal values as a screening test for the separation of PHP patients into Types I and II.

Cyclic AMP↗
PubMed1983

A familial X/Y translocation in a boy with ichthyosis, hypogonadism and mental retardation.

A 14-year-old boy is described with hypogonadism, ichthyosis and mental retardation. His karyotype was 46,Y, der(X),t(X;)(p22;q11). His mother's karyotype was 46,X,der(X),t(X;Y)(p22;q11). Thus the son is nullisomic for the region Xp22 leads to pter and the mother is monosomic for the same region. The steroid sulfatase activity in this boy is discussed in relationship to the enzyme's locus on the X chromosome and the manifestation of ichthyosis.

Adolescent↗
PubMed1983

Seminal plasma zinc and magnesium in infertile men.

Levels of zinc and magnesium were estimated in the seminal plasma of 83 men having various infertility problems. There was a wide overlapping of Zn and Mg mean values among the groups of normal and infertile men, a significant reduction in Mg mean value (but not Zn) only in the group with infection of the accessory genital glands, a very high positive correlation between Zn and Mg mean values in all groups, and a high positive correlation between either Zn or Mg and acid phosphatase (but neither fructose nor sperm count and forward progression) in men with infection, but not in the other groups. Measurement of Mg in seminal plasma can, in combination with other parameters of prostatic function, give useful information regarding male infertility problems, particularly in the case of infection of the accessory genital glands.

Acid Phosphatase↗
PubMed1975

Inhibitory effect of ascorbic acid (vitamin C) on cortisol secretion following adrenal stimulation in children.

Measurements of plasma cortisol values before and at 4 and 6 hours after intramuscular administration of a depot preparation of synthetic b1-24 corticotrophin were carried out in 12 healthy children (group B) before, as well as on the 5th day of continuous ascorbic acid (AA) administration (1 g t.i.d. orally). Comparison of the results in group B with those of 8 healthy children similarly treated with corticotrophin but not given AA (group A) showed that, on the 5th day of AA administration the mean cortisol values after ACTH were significantly lower than the corresponding values in group A (p less than 0.02), or the post-ACTH values in group B observed on the 1st experimental day, i.e., before AA administration (p less than 0.001). On the other hand, AA administration had no significant effect on the fasting plasma cortisol values. These data suggest that AA excess following adrenal stimulation with ACTH exerts an inhibitory effect on cortisol secretion and consequently it may be of no benefit in conditions of stress.

Adolescent↗