Remembering the ribosome.
A recent review of Orgel's hypothesis by Kirkwood is considered in context of what is known about ribosomes.
Animals↗
Biomedical subjects
D I Kurtz
Publications and source records attributed to D I Kurtz.
A decrease in the number of active mouse liver ribosomes during aging.
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Aging↗
Should animal ribosomes be expected to participate in an "error catastrophe"?
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Aging↗
The effect of ageing on in vitro fidelity of translation in mouse liver.
In a polyuridylic acid (poly(U)) stimulated in vitro assay, there is an age-related reduction in polyphenylalanine synthesis with mouse liver microsomes. As measured by the incorporation of leucine under the same conditions, old microsomes make fewer errors in translation than do young ones. Old microsomes have a higher requirement for Mg2+ than young for the optimal synthesis on both acids, suggesting an age-related deterioration in poly(U) complexing ability.
Aging↗