How molecules evolve in eubacteria.
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Bacteria↗
Biomedical subjects
D Huson
Publications and source records attributed to D Huson.
Invariable sites models and their use in phylogeny reconstruction.
Phylogenetic inference is well known to be problematic if both long and short branches occur together in the underlying tree. With biological data, correcting for this problem may require simultaneous consideration for both substitution biases and rate heterogeneity between lineages and across sequence positions. A particular form of the latter is the presence of invariable sites, which are well known to mislead estimation of genetic divergences. Here we describe a capture-recapture method to estimate the proportion of invariable sites in an alignment of amino acids or nucleotides. We use it to investigate phylogenetic signals in 18S ribosomal DNA sequences from Holometabolus insects. Our results suggest that, as taxa diverged, their 18S rDNA sequences have altered in both their distribution of sites that can vary as well as in their base compositions.
Animals↗
[Limit setting as an important task for nurses in ambulatory drug abuse treatment. More than handing out cups of methadone].
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Humans↗