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Biomedical subjects

D Hunt

Publications and source records attributed to D Hunt.

At least 253 records · Page 14Linked to original sources
PubMed1969

Bundle-branch block in acute myocardial infarction.

Bundle-branch block was present in 41 out of 415 patients admitted to a coronary care unit with acute myocardial infarction and was associated with more severe clinical infarction and an overall mortality of 56%. It is probable that permanent bundle-branch block develops soon after infarction and that most of the patients with permanent block have had clinically severe infarction. Bundle-branch block developing during observation is usually transient, and the later it develops the sooner it resolves.Analysis of the arrhythmias and clinical course of the patients suggests that those with bundle-branch block and shock and those in whom bundle-branch block is present on admission may benefit from the use of a demand pacemaker attached to a transvenous pacemaker catheter, though the dividends of pacing may be small and the risks of the procedure significant. Post-mortem examination of 17 hearts showed extensive infarction, usually involving the septum, and severe coronary artery disease.

Adult↗
PubMedDate not supplied

An automated electrical safety and preventive maintenance program.

The Miami Heart Institute's Electrical Safety and Preventive Maintenance Program has been designed as a stand-alone component of a large-scale, computer-based hospital information system. It ensures regularly scheduled routine inspections, preventive maintenance and, where applicable, calibration of the institution's diagnostic, therapeutic and other electrical equipment used in patient care. The program also schedules and documents inspection of buildings, service equipment and grounding systems. The software consists of a single program which permits on-line entry, editing and display of information as well as automatic, unattended generation of printed forms. This program has been in continuous use since May, 1974.

Computers↗
PubMedDate not supplied

TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates.

Cloned T-cell lines from two nonhuman primate species were phenotyped and their mRNA analyzed for cytokine profiles by RT-PCR procedures. PBMC from rhesus macaques showed a relatively high frequency of cloned T-cell lines with a TH1-like profile; PBMC from sooty mangabeys showed a relatively high frequency of TH2-like cloned T-cell lines. In vitro activated macaque PBMC also resulted in a high frequency of CD4+, CD8+ dual marked cells. These findings suggest that cytokine analysis of cloned T-cell lines from nonhuman primates provides a means to distinguish subsets of both CD4+ and CD8+ T cells.

Animals↗
PubMedDate not supplied

Observer sensitivity to retinal vessel diameter and tortuosity in retinopathy of prematurity: a model system.

BACKGROUND: Abnormally increased diameter and tortuosity of retinal blood vessels in the posterior pole, or "plus disease," is recognized as a powerful predictor of poor outcome in eyes with retinopathy of prematurity (ROP). Although the diagnosis of plus disease depends upon the examiner's ability to examine retinal blood vessels, the ability of the human observer to identify changes in retinal blood vessel diameter and tortuosity accurately has not been studied. METHODS: Using computer-aided analysis of fundus photographs from eyes with a wide range of ROP severity, we generated tracings of posterior pole blood vessels which varied by quintiles of mean vessel diameter and tortuosity. Subjects (23 naive and 12 expert observers) ranked groups of tracings in order of increasing mean vessel diameter and tortuosity. These ranking tests were performed on tracings derived from the same fundus and tracings derived from distinct fundi. In a similar fashion, subjects also compared one designated standard fundus tracing with 25 distinct fundus tracings. RESULTS: Vessel diameter was assessed correctly more often than vessel tortuosity, both among similar (> 99% vs 92% of the time, respectively, P < 0.001), or among distinct (88% vs 78% of the time, respectively, P < 0.001) fundus images. The mean vessel diameter and tortuosity of 25 distinct fundus images were correctly ranked versus a standard image in 89% of attempts. Assessments of increments in vessel diameter and tortuosity were independent. Naive and expert subjects performed indistinguishably on all tests. CONCLUSIONS: Intelligent human observers have considerable ability to discern clinically relevant increments in blood vessel diameter and tortuosity. This ability may facilitate standardization in the diagnosis of plus disease in ROP.

Computer Simulation↗
PubMedDate not supplied

Surgical treatment of angina pectoris in the elderly.

We collected hospital and follow-up data for a consecutive series of 35 patients aged 65 years and over who underwent coronary artery bypass grafting for the relief of severe angina pectoris between January, 1974, and June, 1979. The inhospital mortality was 2.8% (one patient). Three patients (9%) suffered perioperative myocardial infaction, three (9%) were reoperated upon for early postoperative bleeding, and four (11%) had significant cerebrovascular complications. Only the latter rate differs significantly (P = 0.05) from the rate of complications reported in published series which include patients of all ages. Late mortality at a mean of 24.3 months follow-up was 12% (four late deaths). Relief of angina in survivors was excellent, with 20 of the 30 survivors (67%) free of chest pain at the time of follow-up. Twenty-five of the 30 survivors (82%) reported no limitation of their activities. Results in the elderly group were compared with those obtained for 322 consecutive patients of all ages, tha latter group having an operative mortality of 3.4%, a late mortality (at a mean of 15 months follow-up) of 12%, complete relief of angina in 62% and complete freedom from physical incapacity in 61% of survivors. Good short-term and long-term results can be obtained from coronary artery bypass grafting in symptomatic elderly patients, but with an increased risk of cerebrovascular complications.

Aged↗