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Biomedical subjects

D Huber

Publications and source records attributed to D Huber.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Temperature monitoring of interstitial thermal tissue coagulation using MR phase images.

The temperature-dependent water proton frequency shift was investigated for temperature monitoring of interstitial thermal coagulation. A procedure for on-line temperature calculation was developed, and errors due to temperature-dependent susceptibility were investigated by finite element analysis and reference measurements. The temperature coefficient of magnetic susceptibility and proton chemical shift were determined for brain tissue and other substances. With the proposed procedure, the location of isotherms could be well visualized during laser-induced interstitial coagulation in vitro and in vivo. Systematic errors caused by magnetic susceptibility changes with temperature depend strongly on the characteristics of the heat source and can exceed susceptibility effects caused by physiologic tissue changes. For the laser applicators discussed here, however, a first order compensation for this effect was found to be satisfactory, because it reduces the absolute error to the range of +/- 1 degrees C. The proposed method represents a very promising approach for monitoring of the interstitial thermal coagulation.

Adipose Tissue↗
PubMedDate not supplied

[The effectiveness of the initial interview at a psychosomatic- psychotherapeutic outpatient unit].

In a cross sectional study of 1945 consecutive patients seen at a psychosomatic-psychotherapeutic outpatient unit between 1993 and 1995, we investigated how the therapists assessed the effectiveness of their work and what correlations there were with patient characteristics and with the way the therapists conducted the initial session. The therapists' ratings indicated that about two thirds of the patients benefited from the consultation. In the multivariate analysis of the data the most important determinants of effectiveness were found to be the patient's motivation, the ICD diagnosis, the patient's level of personality organisation and the reason for the consultation. In addition, we did a one-year follow-up of 260 patients to analyse the determinants that help patients to agree to the proposed treatment plan. Of the 235 patients for whom treatment was recommended, 174 (74%) actually began a treatment program. Our results show that a patient is more likely to accept the treatment recommendation if the therapist conducts the session in a certain way (e.g. provides detailed information) and helps the patient to find an appropriate therapist.

Adult↗
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Transepithelial migration of neutrophils.

Neutrophils are a key cell type of nonadaptive immune system and are the first phagocytic cell type that reaches mucosal inflammatory sites. On the last stage of their journey from the blood stream to a mucosal surface, neutrophils cross a generally sealed epithelium by migrating along the paracellular pathway to the luminal side of the epithelial layer. This last step involves a specific receptor-mediated adhesion event of the neutrophil to the epithelium, followed by a rapid and highly coordinated reversible opening of the epithelial intercellular junctions that allows the transmigration of the neutrophils. Although we do not yet understand the molecular mechanisms that mediate this transmigration process, the last years witnessed the discovery of the first neutrophil and epithelial cell surface proteins critically involved in transepithelial migration of neutrophils.

Animals↗
PubMedDate not supplied

Replicating Project LINC in two midwestern states. Implications for policy development.

Project LINC--Ladders in Nursing Careers--was developed in New York City in 1988 to address a nursing shortage crisis by providing educational and career advancement opportunities for nursing attendants and licensed practical nurses (LPNs) employed in hospitals and nursing homes (1). The project was designed to assist persons from low-income, disadvantaged backgrounds to over-come the typical educational, financial, and social barriers they experienced in returning to school to become nurses. In the first five years, nearly 500 participants from 60 employers were enrolled, 70 percent of whom were members of minority groups (2). [symbol: see text] Project LINC has been replicated in eight states. A qualitative evaluation of Iowa Project LINC (IPL) and North Dakota Project LINC (NDPL) was conducted over a 20-month period beginning one year following implementation. The state programs were compared with one another and with the national model. The findings shed light on how initial and changing conditions influence program structures, processes, and outcomes. Interventions like the Project LINC replication programs are useful to those concerned with providing career advancement opportunities in health care for nontraditional, minority, or low-income students in rural areas.

Career Mobility↗
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Humans↗
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Humans↗